De-Nol tabs 120mg #112

Instruction for De-Nol

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De-Nol is a unique drug that has anti-ulcer properties and fights the infection caused by Helicobacter pylori. Until recently, a hereditary predisposition and nutritional errors were considered to be the causes of ulcerative defects in the gastrointestinal tract, but this all changed after the discovery of Helicobacter pylori bacteria. These bacteria, as scientists have found, play a major role in the formation of ulcers and feel great in the acidic environment of the stomach, as if burrowing into the mucous membrane, thereby triggering the mechanism of its damage. Once in the human stomach, Helicobacter pylori secretes a substance (urease), which irritates the mucous layer, in response to this, the body enhances the synthesis and secretion of hydrochloric acid and pepsin. All these factors together lead to an imbalance between the protective layer of mucus and the aggressive environment in the stomach (hydrochloric acid and bile acids from the duodenum), which leads to gastritis, erosion, and then to ulcerative defects in the stomach and duodenum.

Pharmacological effect

De-Nol is an antiulcer drug. The main pharmacological features of De-Nol include: antimicrobial, astringent, gastroprotective, regenerative and antiulcer effects. The astringent property of the drug is associated with the presence of bismuth in the composition. The medicine binds to proteins and forms films on the surface of ulcers and the entire stomach, which not only protects defects from the harmful effects of gastric juice, but also predisposes to faster healing of ulcers. Bismuth also has a bactericidal effect, which is due to the ability of the enzymes of this agent to dissolve the bacterial membrane, thereby making it vulnerable. Thanks to these enzymes, the drug penetrates far into the gastric mucosa and acts there. It increases the content of prostaglandin E, contributes to an increase in the level of epidermal growth factor in the ulcer area. This tool is almost not absorbed in the stomach and intestines, is excreted from the body along with feces.

The composition of the drug

De-Nol consists of the main constituent of bismuth tripotassium dicitrate 304.6 mg and additional compounds. The medication is in the form of tablets.

Indications for use

The use of the drug De-Nol in the presence of peptic ulcer of the stomach and duodenum is shown. And also for the treatment of gastritis and gastroduodenitis. The medication can be prescribed to patients with irritable bowel syndrome.

Instructions for use

De-Nol is used in two ways. With scheme number 1, the drug is taken 1 tablet 4 times a day for half an hour before a meal, with the second scheme, the patient should take 2 in the morning and evening.
This instruction does not contain the facts about the medication in its entirety, therefore, before starting treatment, it is necessary to consult a qualified specialist and get acquainted with all the negative aspects of the therapy with this remedy, and not rely completely on this instruction. The attending physician will independently determine the dosage of the medication and the duration of treatment, which depend on the clinical picture of the disease and the individual differences of the patient's body.

Pregnancy and lactation

Pregnant and lactating this medication is not indicated for use. It should be noted that the risk when pregnant women use medications is that almost any medication affects fast-growing fetal cells and even the smallest disturbances in the process of dividing these cells, especially in the first trimester, can cause birth defects of all kinds of localizations in the fetus . The impossibility of conducting full-fledged studies on pregnant women, as well as breast-feeding, does not allow us to understand whether this drug negatively affects the fetus, whether it crosses the placenta, passes into breast milk, therefore, in order to minimize the risks, take either a pregnant woman or a nursing mother a doctor decides another drug, understanding and accepting all responsibility.

Contraindications and side effects

De-Nol is contraindicated if the patient has allergic reactions to the components of the drug, with severe renal failure, children under 14 years of age, pregnant and lactating.
Adverse reactions include: all kinds of stool disorders, vomiting, allergies, nausea, as well as long-term use of bismuth intoxication symptoms, indicated below in the section Overdose.

Features of the reception

The drug can not be used for more than 8 weeks. It is necessary to strictly observe the dosages indicated in the instructions, and it is also not allowed to combine other drugs containing bismuth with taking De-Nol medicine. During therapy, darkening of the tongue and color of feces is possible.

Alcohol compatibility

The drug, due to the harmful effects of alcohol on the whole body as a whole, and especially on the gastric mucosa, is not allowed to be combined with alcohol intake. In addition, alcohol weakens the effect of the drug and enhances its side effects, increases the time it takes for the drug to be removed from the body.

Compatibility with other medicines

When taking De-Nol, along with fruit juices and milk, as well as simultaneously with the Almagel medication and similar drugs, the agent binds. Do not use with other medicines that contain bismuth. Taking the drug adversely affects the absorption of antibiotics.

Overdose

Symptoms of an overdose after using the drug are the same as with bismuth poisoning. The patient may have: bismuth impregnation of the skin and mucous membranes, abdominal pain, cramps, brain damage (confusion, dysarthria), tooth loss, osteoarthropathy, decreased urine output, up to acute renal failure. When all these symptoms appear, you need to stop taking the drug, and in more severe cases, hospitalize.

Reviews of patients and doctors

Doctors love De-Nol for its good tolerance, a small number of adverse reactions, and most importantly for its high effectiveness in treating ulcers and the ability to not cause resistance in bacteria, which allows the use of De-Nol in complex treatment of ulcers regularly, without fear of addiction. The medication not only fights against Helicobacter pylori infection, but also protects the gastric mucosa. After using De-Nol in complex treatment, patients have a good healing of the ulcer defect, as well as a significant reduction in the frequency of repeated cases of the disease. Patients also praise the medication, indicating its easy tolerance to De-Nol, its good effect, a decrease in the frequency of recurrence of attacks of pain in the stomach.

Storage rules

Keep this medication necessary in a cool, dark and out of the reach of children, observing a temperature of 8-25 degrees Celsius. Shelf life is 4 years. After a period of 4 years, the use of the drug is prohibited.

Terms of sell

You don't need a prescription to buy De-Nol.