Rebagit tabs 100mg #90

Instruction for Rebagit

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Release form and composition

The drug is produced in the form of film-coated tablets: white or almost white, round, biconvex (in blisters of 7 pcs., 3, 6 or 12 blisters in a cardboard box; in blisters of 10 pcs., 2, 3, 4 or 9 blisters in a cardboard bundle; in blisters of 21 pcs., 1, 2, 4 or 8 blisters with instructions for use of Rebagit in a cardboard bundle).
1 tablet contains:
    active substance: rebamipide - 100 mg;
    auxiliary components: pregelatinized starch, croscarmellose sodium, citric acid, mannitol, sodium lauryl sulfate, magnesium stearate, talc;
    film coat: Opadry white 03B28796 (macrogol 400, hypromellose 6cP, titanium dioxide).

Pharmacodynamics

Rebagit is a gastroprotective drug, the active substance of which is rebamipid. The mechanism of action of the drug is due to the ability of rebamipide to increase the content of prostaglandin E2 (PgE2) in the gastric mucosa and potentiate the synthesis of prostaglandins E2 and GI2 in the contents of gastric juice.
Rebamipid promotes an increase in the mucus content on the surface of the stomach wall as a result of activation of enzymes that accelerate the production of high molecular weight glycoproteins. Against the background of its intake, blood supply improves and the barrier function of the gastric mucosa is activated, alkaline secretion of gastric juice increases, proliferation and metabolism of gastric epithelial cells increase. Rebamipid is involved in the processes associated with the purification of the mucosa from hydroxyl radicals. Suppresses superoxides produced in the presence of Helicobacter pylori by polymorphonuclear leukocytes and neutrophils. Protects the gastric mucosa from bacteria, increases resistance to the damaging effects of non-steroidal anti-inflammatory drugs on the stomach.
It has a cytoprotective effect when exposed to ethanol, acids, alkalis or acetylsalicylic acid on the gastric mucosa.

Pharmacokinetics

After oral administration, rebamipide is actively absorbed. Its maximum plasma concentration (Cmax) when taken at a dose of 100 mg reaches 340 ng / ml after about 2 hours.
Binding to plasma proteins - up to 98.6% (according to in vitro studies).
Rebamipide passes into breast milk.
The half-life (T1 / 2) is approximately 1 hour.
It is excreted through the kidneys, mainly in unchanged form, in an amount of about 10% of the dose taken. Admission at a dose of 600 mg allows you to isolate trace amounts of hydroxylated metabolite.
As a result of repeated use of Rebagit, cumulation of rebamipide was not observed in the body.

Indications for use

The use of Rebagit is indicated for the treatment of gastric ulcer, erosive gastritis, exacerbations of chronic gastritis with increased acid-forming function of the stomach, including as part of combination therapy.
In addition, the drug is prescribed to prevent damage to the mucous membrane of the digestive tract when taking non-steroidal anti-inflammatory drugs.

Contraindications

Absolute:
    pregnancy period;
    breast-feeding;
    age up to 18 years;
    individual intolerance to the components of the drug.
With caution, Rebagit should be taken in elderly patients at the first appointment of rebamipide due to the risk of hypersensitivity reactions to the drug.

Rebagit, instructions for use: method and dosage

Rebagit tablets are taken orally with a sufficient amount of liquid.
Recommended dosage: 1 pc. 3 times a day. Duration of the course is from 14 to 28 days. In some cases, taking into account the clinical picture, treatment can be extended up to 56 days.
If you accidentally skip the next dose, it should not be compensated by doubling the next single dose of the drug. Treatment is continued in accordance with the established dosage regimen.

Side effects

    from the gastrointestinal tract: pain in the abdomen, heartburn, nausea, vomiting, flatulence, constipation, diarrhea, violation of taste sensations;
    from the hematopoiesis system: granulocytopenia, leukopenia;
    on the part of the hepatobiliary system: symptoms of functional liver disorders, an increase in serum glutamine alanine aminotransferase and serum glutamine aspartate aminotransferase;
    from the immune system: skin itching, rash, eczema rashes;
    other reactions: menstrual irregularities.

Overdose

Symptoms of an overdose have not been established. Perhaps the appearance of headache and adverse events from the gastrointestinal tract in the form of nausea, vomiting, abdominal pain, diarrhea or constipation.
Treatment: there is no specific antidote. Immediate gastric lavage and the appointment of symptomatic therapy are required.

Special instructions

Features of the action at the first dose or withdrawal of the drug are absent.

Influence on the ability to drive vehicles and complex mechanisms

During the use of Rebagit, patients are advised to exercise caution when driving vehicles or performing other activities that require an increased concentration of attention.

Pregnancy and lactation

The use of Rebagit during pregnancy and breastfeeding is contraindicated.
If it is necessary to prescribe the drug during lactation, breast-feeding should be discontinued.

Use in childhood

The use of Rebagit tablets is contraindicated for the treatment of children and adolescents under the age of 18 years.

Use in old age

At the first appointment of Rebagit, elderly patients should be careful in connection with the existing risk of hypersensitivity reactions to rebamipid.

Drug interaction

In the treatment of patients with Helicobacter pylori, the use of rebamipide as part of traditional treatment regimens significantly increases the effectiveness of eradication.

Terms and conditions of storage

Keep out of the reach of children.
Store at temperatures up to 25 ° C in a dark place.
Shelf life is 2 years.

Reviews about Rebagit

In reviews of Rebagit, some patients note its high effectiveness in the treatment of chronic gastritis or in the use of combination therapy for erosion of the duodenum and esophagus.
In reviews of a negative nature, patients report that they were forced to stop using the drug due to the development of undesirable side reactions in the form of severe diarrhea, discomfort in the gastrointestinal tract, heartburn, tachycardia.

Terms of sell

You can buy Rebagit without a prescription.