Ulcavis tabs 120mg #112

Instruction for Ulcavis

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Ulcavis is a drug with antiulcer, gastroprotective and anti-Helicobacter properties.

Release form and composition

Dosage form of Ulcavis - film-coated tablets: round, slightly biconvex, beveled, white or almost white; on the break, a white rough mass with a white or almost white shell is visible. Tablets are packed in blisters (10 pcs. / 14 or 15 pcs.) And packed in cardboard boxes (3, 4, 6, 10 or 24 blisters / 2, 4, 6 or 16 blisters).
Composition of 1 tablet:
    active substance: bismuth tripotassium dicitrate - 303.03 mg, which corresponds to 120 mg of bismuth oxide;
    auxiliary components: macrogol 6000 - 6 mg, corn starch - 72.17 mg, magnesium stearate - 2 mg, povidone K30 - 18 mg, potassium polacrilin - 23.8 mg;
    film shell: Opadry II transparent, consisting of macrogol 4000 (2.295 mg), talc (1.7 mg) and polyvinyl alcohol (4.505 mg) - 8.5 mg, titanium dioxide (E171) - 1.5 mg.

Pharmacodynamics

Ulcavis is an anti-ulcer drug with bactericidal activity against the bacteria Helicobacter pylori, astringent and anti-inflammatory effect.
The mechanism of action of the drug is due to the ability of bismuth oxychloride and citrate to precipitate insoluble in the acidic environment of the stomach and form chelate compounds with a protein substrate in the form of a protective film on the surface of erosions and ulcers. Ulcavis increases the synthesis of prostaglandin E, the secretion of bicarbonate and the formation of mucus, stimulates the activity of cytoprotective mechanisms, reduces the activity of pepsin, increases the resistance of the mucous membrane of the gastrointestinal tract (GIT) to the effects of enzymes, hydrochloric acid, bile salts and pepsin. It leads to the accumulation of epidermal growth factor in the defect zone.

Pharmacokinetics

The active substance of the drug is practically not absorbed from the gastrointestinal tract. It is excreted mainly in the feces through the intestines. A small amount of bismuth, which has entered the blood plasma, is excreted by the kidneys.

Indications for use

    functional dyspepsia (only if it is not associated with organic diseases of the gastrointestinal tract);
    chronic gastritis and gastroduodenitis in the acute phase, including those associated with the bacterium Helicobacter pylori;
    peptic ulcer and 12 duodenal ulcer in the acute phase, including associated with Helicobacter pylori;
    irritable bowel syndrome, accompanied mainly by diarrhea.

Contraindications

    severe renal failure (creatinine clearance less than 30 ml / min);
    children under 4 years of age;
    pregnancy;
    lactation;
    increased individual intolerance to the components of the drug.

Instructions for the use of Ulcavis: method and dosage

Ulcavis tablets are taken orally with a small amount of water half an hour before meals.
Recommended dosage of the drug:
    children from 12 years old and adults: 1 tablet 4 times a day (before meals and at night) or 2 tablets 2 times a day;
    children 8–12 years old: 1 tablet 2 times a day;
    children 4-8 years old: 1-2 tablets in 1-2 doses, but not more than 8 mg / kg / day.
The duration of treatment is 4 to 8 weeks.
For the eradication of the H. pylori bacteria, it is advisable to prescribe Ulcavis in combination with other antibacterial drugs, which are characterized by anti-Helicobacter activity.

Side effects

    digestive system: more frequent stools, constipation, nausea, vomiting (these phenomena are moderate and temporary);
    allergic reactions: skin rashes, itching;
    others: with prolonged use of the drug in high doses - encephalopathy.

Overdose

Symptoms: skin rash, dyspeptic disorders, characteristic darkening of the gums in the form of blue lines, inflammation of the oral mucosa; with long-term use of Ulcavis in high doses - impaired renal function. After discontinuation of the drug, these disorders are completely reversible.
As a therapeutic measure, gastric lavage should be done, activated charcoal and a saline laxative should be taken. Further treatment is symptomatic. If renal dysfunction is diagnosed, which is accompanied by a high concentration of bismuth in the blood plasma, it is possible to use chelating agents (penicillamine or sodium dimercaptopropanesulfonate). If renal dysfunction is severe, hemodialysis is performed.

Special instructions

The duration of treatment should not exceed 8 weeks. Do not increase the daily dose recommended by your doctor.
After the end of the course of therapy, in the case of using Ulcavis in recommended doses, the concentration of bismuth in the blood plasma does not exceed 58 μg / l. And although intoxication is possible at a concentration above 100 μg / l, during the period of therapy and within 8 weeks after its termination, the use of other drugs containing bismuth is contraindicated.
The drug may contribute to the staining of feces in a dark color. Some patients may experience slight darkening of the tongue.

Influence on the ability to drive vehicles and complex mechanisms

There was no negative effect of the drug on cognitive and psychomotor functions.

Application during pregnancy and lactation

The drug is contraindicated in women during pregnancy and lactation.

Childhood use

According to the instructions, Ulcavis is contraindicated in children under the age of 4 years.

Drug interactions

Bismuth reduces the absorption of tetracycline.
For half an hour before taking bismuth and half an hour after, it is not recommended to drink some liquids, take food or other drugs, in particular fruit juices, milk, fruits and antacids, since they can reduce the effect of bismuth.

Terms and conditions of storage

Shelf life is 2 years.
Storage conditions - original packaging, place inaccessible to children, temperature up to 25 ° С.

Reviews about Ulcavis

According to reviews, Ulcavis effectively eliminates heartburn and abdominal pain, improves the functioning of the gastrointestinal tract, and, subject to the dosage regimen and diet, helps to cure gastritis and stomach ulcers.

Terms of sell

You can buy Ulcavis without a prescription.