Ketorol tabs 10mg #20

Instruction for Ketorol

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It is used to eliminate pain syndrome of various degrees of intensity and various etiologies (including postoperative pain and oncological pain).

Release form and composition

Ketorol is produced in the form of tablets coated with a special soluble green coating. The biconvex form of the tablet facilitates the process of swallowing the medicine.
    The composition of all medicinal forms of Ketorol includes ketorolac in various concentrations as an active substance. Thus, the tablets contain 10 mg of ketorolac, 30 mg in 1 ml in solution, and 20 mg in 1 g (2%) in the gel.
Each tablet has a special embossing in the form of a Latin letter S. The tablets are packaged in 10 pieces in a plastic blister with a metallic coating. The package may have a different number of blisters, from which the price of the drug is radically different.

Pharmacological effect

Ketorol is a non-steroidal anti-inflammatory agent with a predominantly analgesic effect. The active ingredient of the drug is ketorolac (ketorolac tromethamine). Ketorolac has a moderate antipyretic effect, anti-inflammatory effect and pronounced analgesic effect.
Ketorolac mainly in peripheral tissues causes indiscriminate inhibition of the activity of cyclo-oxygenase 1 and type 2 enzymes, as a result of which inhibition of the formation of prostaglandins is observed. Prostaglandins play an important role in the appearance of pain, inflammation reactions and the mechanism of thermoregulation. According to the chemical structure, the active substance Ketorol is a racemic mixture of + R- and -S- enantiomers, and the anesthetic effect of the drug is due to the -S-enantiomers.
Ketorol does not affect the receptors for opioids, does not inhibit the respiratory center, does not have a calming and anti-depressive effect, does not cause drug dependence. The analgesic effect of Ketorol is comparable in strength to morphine and much more superior to nonsteroidal anti-inflammatory drugs of other groups. The onset of analgesic action after intramuscular administration or ingestion begins after 0.5 and 1 hour, respectively. The maximum analgesic effect is observed in 1-2 hours.

Indications for use

In the form of a solution and tablets, Ketorol is used to relieve pain syndrome of various origins of medium and strong intensity:
    Dislocations, sprains, other injuries and their consequences;
    Rheumatic diseases;
    Toothache;
    Radiculitis, neuralgia;
    Myalgia, arthralgia;
    Pain in the postoperative and postpartum period;
    Oncological diseases.
In the form of a gel, the drug is used topically for pain syndrome caused by the following diseases:
    Bursitis, epicondylitis, tendonitis, synovitis;
    Rheumatic diseases;
    Radiculitis, neuralgia;
    Arthralgia, myalgia;
    Injuries (ligament damage, bruises and inflammation of soft tissues, including those of post-traumatic origin).

Contraindications for Ketorol

Before taking the drug, the patient is recommended to carefully study the enclosed instructions, since Ketorol tablets are contraindicated in the presence of the following conditions:
    Bronchial asthma;
    Hyperkalemia;
    Lactase deficiency;
    The age of patients under 16 years;
    Pregnancy and lactation period;
    Gastrointestinal bleeding or suspicion of them;
    Ulcerative colitis or Crohn's disease in the acute phase;
    History of asthma, bronchospasm, frequent obstructive bronchitis;
    Severe damage to the liver and kidneys, accompanied by a violation of the work of these organs;
    Hereditary blood diseases, accompanied by a violation of its coagulation function;
    Individual intolerance to acetylsalicylic acid or drugs from the group of nonsteroidal anti-inflammatory drugs;
    Chronic diseases of the gastrointestinal tract with the presence of ulcerative-erosive surface
Relative contraindications include:
    Coronary heart disease;
    Diabetes;
    Heart failure;
    Arterial hypertension;
    Cholestasis;
    Age of patients older than 60 years;
    Simultaneous reception of anticoagulants or antiplatelet agents.

Use during pregnancy and lactation

Solution and tablets during pregnancy and breastfeeding are contraindicated.
External use is allowed in the 1st and 2nd trimesters, but after the 27th week the use of the gel can cause prolonged pregnancy or complicated delivery.

Instructions for use

The instructions for use indicate that Ketorol tablets are taken orally in a single dose of 10 mg.
    In case of severe pain syndrome, the drug is taken repeatedly in 10 mg up to 4 times / day, depending on the severity of the pain. The maximum daily dose is 40 mg. A minimum effective dose should be applied. When taken orally, the duration of treatment should not exceed 5 days.
    When switching from parenteral administration of the drug to its ingestion, the total daily dose of both dosage forms on the day of transfer should not exceed 90 mg for patients aged 16 to 65 years and 60 mg for patients older than 65 years or with impaired renal function. In this case, the dose of the drug in tablets on the day of transition should not exceed 30 mg.

Side effects

Ketorol tablets and injections can cause unwanted reactions in patients such as:
    bronchospasm, laryngeal edema, rhinitis;
    increased blood pressure, fainting, pulmonary edema;
    rectal, epistaxis, of postoperative bleeding wounds;
    diarrhea, stomach pain, vomiting, constipation, flatulence, stomatitis, nausea, heartburn;
    weight gain, swelling of feet, fingers, ankles, legs, face, tongue, excessive sweating, fever;
    headache, drowsiness, dizziness, hyperactivity, depression, tinnitus, hearing loss, blurred vision.
    itching, urticaria, discoloration of the face, skin rash, eyelid edema, shortness of breath, wheezing, chest tightness;
    low back pain, acute renal failure, frequent urination, nephritis (inflammation of the kidneys), decrease or increase in urine volume;
    leukopenia (increase in leukocytes in the blood), eosinophilia (increase in the number of eosinophils), anemia (decrease in the number of red blood cells or hemoglobin);
    purpura, skin rash, urticaria, Lyell's syndrome (allergic dermatitis as a reaction to drugs), Stevens-Johnson syndrome (the appearance of bubbles in the skin and mucous membrane of various organs).

Overdose

Possible signs of an overdose of Ketorol: nausea, abdominal pain, vomiting, peptic ulcers or erosive lesions of the gastrointestinal tract, metabolic acidosis, impaired renal function.
Treatment: gastric lavage followed by the appointment of adsorbing drugs, symptomatic treatment. Not derived largely by dialysis methods.

special instructions

    When using tablets for more than 5 days, the risk of side effects in a patient increases, therefore, in the absence of the expected therapeutic effect, you should consult your doctor again.
    With a significantly pronounced pain syndrome or the presence of contraindications for oral administration of the drug, Ketorol is prescribed to the patient in the form of an injection.
    To reduce the risk of developing drug ulcers, the patient can simultaneously with Ketorol tablets prescribe antacid or enveloping drugs to reduce the irritant effect of the main substance of the tablet on the mucous membranes of the digestive tract.
    Patients with impaired blood coagulation during the period of drug treatment should constantly monitor the level of platelets in the blood, especially in postoperative patients.
During drug treatment patients should be careful when driving vehicles and managing complex devices that require high concentration of attention.

Storage conditions

Store in a dry, protected from light, out of reach of children at a temperature not exceeding 25 ° C. Shelf life - 3 years.

Terms of sell

You can buy Ketorol without a prescription.