Pangrol 25000 caps #50

Instruction for Pangrol

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Pangrol 25000 is an enzyme preparation that fills the deficiency of pancreatic enzymes in diseases of the gastrointestinal tract (GIT).

Release form and composition

The drug is produced in the form of enteric-soluble capsules: cylindrical with hemispherical ends, size 0, gelatinous, solid, opaque, light orange body, yellowish-green cap; inside the capsules are mini-tablets, enteric coated, which have a shiny surface of light beige color and a cylindrical shape (20, 50 or 100 pcs. in polypropylene bottles, in a cardboard box 1 bottle and instructions for use Pangrol 25000).
1 enteric-coated mini-tablet contains:
    active substance: pancreatin - 356.1 mg, with a minimum lipase activity - 25,000 units (unit of action), amylase - 22,500 units, proteases - 1250 units;
    auxiliary components: croscarmellose sodium, microcrystalline cellulose, anhydrous colloidal silicon dioxide, hydrogenated castor oil, magnesium stearate;
    enteric coating: copolymer of methacrylic acid and ethyl acrylate (1: 1) in the form of a 30% dispersion, triethyl citrate, simethicone emulsion 30%, talc.
The composition of the capsule shell:
    case: gelatin, titanium dioxide (E171), iron dye oxide red (E172), iron dye oxide yellow (E172);
    cap: gelatin, titanium dioxide (E171), indigo carmine (E132), dye quinoline yellow (E104).

Pharmacodynamics

Pangrol 25000 - a drug that compensates for the deficiency of pancreatic enzymes; It has a proteolytic, amylolytic and lipolytic effect.
Its active component, pancreatin, is an extract in the form of a powder, which is obtained from the pancreas of pigs. Enzymes that are part of pancreatin (protease, lipase, amylase) are involved in the breakdown of carbohydrates, fats and proteins that come with food. Pancreatin, compensating for the enzymatic insufficiency of the pancreas, helps to normalize digestion and improve the functional state of the digestive tract.

Pharmacokinetics

After ingestion, the capsules dissolve quickly in the stomach and release mini-tablets. The enteric coating of the mini-tablets is acid resistant, which allows the enzymes to remain stable in the acidic environment of the stomach. As a result of mixing mini-tablets with intestinal contents, an even distribution of enzymes is carried out. Enzyme activation occurs after dissolution of the membrane of mini-tablets in the small intestine at a slightly alkaline or neutral acidity (pH).
Not absorbed in the digestive tract, pancreatin is excreted through the intestines.

Indications for use

The use of Pangrol is indicated for adults and children as a replacement therapy for exocrine pancreatic insufficiency in the following pathologies and conditions:
    chronic pancreatitis;
    subacute pancreatitis;
    cystic fibrosis;
    conditions after surgical interventions on the stomach or pancreas regarding complete or partial resection of the organ;
    pancreas cancer;
    narrowing of the pancreatic duct due to a tumor or gallstones;
    conditions accompanied by flatulence, a violation of the digestion of food, diarrhea that arose after irradiation of the digestive tract - as part of combination therapy;
    Schwachman-Diamond syndrome;
    other diseases that are accompanied by exocrine pancreatic insufficiency.
In addition, the drug is prescribed for patients with relative enzyme deficiency in such conditions and situations as:
    functional gastrointestinal upset due to acute intestinal infection, irritable bowel syndrome;
    eating plant or fatty foods that are difficult to digest.
Pangrol 25000 capsules are also used in preparation for x-ray or ultrasound examination of the abdominal organs.

Contraindications

Absolute:
    period of exacerbation of chronic pancreatitis;
    acute pancreatitis;
    hypersensitivity to the components of the drug.
During pregnancy, the use of Pangrol is allowed in cases where the expected effect for the mother justifies the possible risk to the fetus.

Pangrol, instruction for use: method and dosage

Pangrol 25000 capsules are taken orally with food, swallowed whole and washed down with a sufficient (200 ml) amount of water or other liquid.
When treating young children or elderly patients, taking an entire capsule can be difficult. In this case, the capsule should be opened by separating the lid from the case, and pour its contents (mini-tablets) into a glass with a small amount of liquid or food that does not require chewing (for example, applesauce, fruit juice). The resulting mixture is taken immediately after preparation, it is not subject to storage.
The doctor selects the dose of the drug and the duration of the course of treatment individually, taking into account the severity and course of the disease, the volume and composition of the food consumed.
Recommended Dosing Pangrol:
    adults: 1-2 pcs. during each meal. The dose of enzymes should be increased only under the supervision of a doctor, taking into account the dynamics of easing abdominal pain, a decrease in steatorrhea and other symptoms. The maximum daily dose is 15,000–20,000 lipase units per 1 kg of patient weight (units / kg);
    children: based on 500-1000 lipase units / kg of the child’s weight for each meal.
In cystic fibrosis, children under 4 years of age are prescribed 1000 lipase units / kg for each meal, and children over 4 years of age are prescribed 500 lipase units / kg during each meal. The dose of Pangrol 25000 depends on the severity of the disease, it is selected under the control of steatorrhea and subject to an optimal diet. In most cases, the daily dose is not more than 10,000 lipase units / kg or 4000 lipase units per 0.001 kg of fat consumed.

Side effects

    from the gastrointestinal tract: very often (≥ 1/10) - pain in the abdomen; often (from ≥ 1/100 to <1/10) - bloating, nausea, vomiting, diarrhea;
    on the part of the skin and subcutaneous tissues: rarely (from ≥ 1/10 000 to <1/1000) - rash; frequency is not established (it is impossible to establish the frequency based on available data) - itching, urticaria.

Overdose

In patients with cystic fibrosis, taking a high dose of pancreatic enzymes is associated with a risk of developing hyperuricosuria and hyperuricemia.
If an overdose is suspected, the drug should be discontinued immediately. To stop adverse events, symptomatic therapy is performed.

Special instructions

When treating 25,000 patients with cystic fibrosis with Pangrol, caution is advised due to the fact that, with high doses of pancreatin preparations, there are cases of ileum, cecum, and colon stricture (fibrosing colonopathy) in this category of patients. In order to exclude colon damage in case of the appearance of symptoms unusual for cystic fibrosis or a change in their nature, it is necessary to conduct a medical examination, especially if the drug is used in a daily dose of more than 10,000 lipase units / kg.

Influence on the ability to drive vehicles and complex mechanisms

The use of Pangrol 25000 does not affect the ability of patients to perform potentially dangerous types of work that require increased attention and speed of response, including driving.

Pregnancy and lactation

It is allowed to prescribe Pangrol 25000 during pregnancy to those women for whom the expected effect of therapy is higher than the possible risk to the fetus.
When breast-feeding, pancreatic enzymes can be taken, since the harmful effect of enzymes on the baby through breast milk is not expected.

Terms and conditions of storage

Keep out of the reach of children.
Store at temperatures up to 25 ° C.
Shelf life is 2 years.

Reviews of Pangrol 25000

Reviews about Pangrol 25,000 are positive. Along with the effectiveness of the drug to improve digestion, patients note that it acts quickly, helps with overeating, and does not cause side effects.

Terms of sell

You don't need a prescription to buy Pangrol.