Micrasim caps 25.000 #50

Instruction for Micrasim

Reed more and buy Micrasim here

Micrasim is an enzyme preparation that provides higher digestive activity.

Release form and composition

Dosage form - capsules: gelatinous solid with a transparent body of two types: size No. 2 - with a brown lid, size No. 0 - dark orange, inside the capsules - enteric-coated pellets of spherical, cylindrical or irregular shape from brown to light brown in color with a specific smell (10 pcs. in blisters, in a cardboard bundle of 2 or 5 packs).
The active substance of Micrasim is pancreatin, in 1 capsule:
    Size No. 2 - 10,000 IU (125 mg), which is equivalent to a nominal lipolytic activity of 168 mg or activity: amylase 7500 IU, lipase 10 000 IU, protease 520 IU;
    Size No. 0 - 25,000 IU (312 mg), which is equivalent to a nominal lipolytic activity of 420 mg or activity: amylase 19,000 IU, lipase 25,000 IU, protease 1300 IU.
Auxiliary components: enteric-soluble pellet shell - a copolymer of ethyl acrylate and methacrylic acid (1: 1) (in the form of a 30% dispersion, additionally containing sodium lauryl sulfate and polysorbate 80), triethyl citrate, simethicone emulsion 30% (in dry form 32.6%) in the composition which: methyl cellulose, suspended colloidal silicon, sorbic acid, precipitated silicon colloidal, talc, water.
The composition of the capsule body: gelatin, water.
The composition of the capsule lid: gelatin, crimson dye (Ponceau 4R), patented blue dye, quinoline yellow dye, titanium dioxide, water.

Indications for use

    Pancreatic enzyme deficiency: pancreatic fibrosis (cystic fibrosis), pancreatic tumors, chronic pancreatitis, the period after surgery on the pancreas - as a replacement therapy;
    Symptomatic treatment as part of complex therapy for the correction of a digestive disorder that arose against the background of: a condition after resection of the gallbladder, stomach, part of the intestine; pathologies of the small and large intestine, duodenum, proceeding with a violation of the promotion of intestinal contents; conditions and diseases accompanied by a disorder in the process of biliary excretion, including cholecystitis, liver diseases, stones in the gallbladder, chronic pathology of the biliary tract, compression of the biliary tract by cystic growths and neoplasms;
    Improving the digestion process in adults and children with normal gastrointestinal function (GIT): with errors in the diet (including overeating, eating coarse and fatty foods, irregular nutrition), with a sedentary lifestyle, impaired chewing function, prolonged immobilization;
    Use in complex preparation for ultrasound and x-ray examination of the abdominal organs.

Contraindications

    Acute pancreatitis;
    Chronic pancreatitis in the acute stage;
    Hypersensitivity to Micrasim.
The appointment of Micrasim during pregnancy and breastfeeding is indicated if the expected therapeutic effect for the mother outweighs the possible risk to the fetus and baby.

Dosage and administration

Capsules Micrasim are taken orally, washed down with a small amount of water or fruit juice (with the exception of alkaline liquid). When prescribing a single dose of 2 or more capsules, it is recommended to take ½ of the total amount of the drug before meals, the other half - directly during meals. A dose of 1 capsule is taken with meals.
In order to facilitate swallowing, children or elderly patients can take the drug without capsule shell by dissolving its contents in liquid or liquid food (pH below 5.0), which does not need to be chewed (yogurt, applesauce). Chewing, crushing pellets or mixing with food (pH above 5.5) destroys their membrane, which protects against the effects of gastric juice. It is necessary to prepare a mixture of pellets with liquid or food before direct administration.
An individual selection of the dose of Micrasim is recommended taking into account the composition of the diet, the severity of the symptoms of the disease and the age of the patient.
Taking Micrasim can last from several days with digestive disorders to several months and years with prolonged replacement therapy.
The maximum allowable daily dose for children: up to one and a half years - 50,000 units, at the age of one and a half years and older - 100,000 units.
Recommended dosage for replacement therapy of various types of exocrine pancreatic insufficiency:
    Steatorrhea, with a fat content in feces of more than 15 g per day: 25,000 units of lipase with each meal for patients with diarrhea, weight loss and lack of effect from diet therapy. With good tolerability of the drug, to achieve a clinical effect, an increase in a single dose to 30,000-35,000 units of lipase is indicated. If there is no improvement in treatment results, it is necessary to clarify the diagnosis or reduce fat intake and consider the appointment of concurrent administration of proton pump inhibitors. In the absence of diarrhea and weight loss on the background of mild steatorrhea, Micrasim is prescribed in a single dose of 10,000-25,000 units of lipase;
    Cystic fibrosis: the initial single dose for children under 4 years of age - based on 1000 units of lipase per 1 kg of the child’s weight and 500 units of lipase per 1 kg - at the age of 4 years or more. The dose should be adjusted taking into account the nutritional status and severity of steatorrhea. The appointment of a maintenance dose of more than 10,000 units of lipase per 1 kg of body weight per day is not recommended.

Side effects

    Perhaps: the development of allergic reactions;
    Rarely: while taking high doses - nausea, discomfort in the epigastric region, diarrhea or constipation;
    Other: prolonged use of high doses can contribute to the development of hyperuricemia, hyperuricosuria.

Special instructions

Long-term use of Micrasim in high doses should be accompanied by regular medical supervision.
Inefficiency of therapy can be observed against the background of inactivation of enzymes as a result of acidification of the contents of the duodenum, concomitant diseases of the small intestine (including dysbiosis and helminth infestations), non-compliance with the recommended regimen, and administration of enzymes that have lost activity.
The effect of pancreatin on the speed of the patient's psychomotor reactions, including the ability to drive vehicles and mechanisms, has not been established.

Drug interaction

The simultaneous use of pancreatin reduces the absorption of iron preparations.

Terms and conditions of storage

To store in the place protected from light and moisture at a temperature up to 25 ° C. Keep out of the reach of children.
Shelf life is 2 years.

Terms of sell

A prescription is not required to buy Micrasim.