Dorzopt Plus drops 20mg/ml + 5mg/ml 5ml

Instruction for Dorzopt Plus

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Description and composition

The drug Dorzopt Plus is produced in the form of a clear, odorless liquid. The solution has a viscous consistency. The composition of the drug contains 2 active substances, namely:
    dorzolamide;
    timolol.
The list of auxiliary components includes:
    hyethylosis;
    citric acid monohydrate;
    sodium hydroxide;
    mannitol;
    benzalkonium chloride;
    sodium hydroxide solution;
    hydrochloric acid solution;
    purified water.
The listed components provide an increase in the effectiveness of the drug composition. The constituent elements can also be considered as preservatives that ensure the storage of active substances for the period declared by the manufacturer.

Pharmacological group

The active substances provide a blockade of m-cholinergic receptors to provide tension to the ciliary muscle of the eye and at the same time to relax the muscles that constrict the pupil. Relaxation of the ciliary muscles of the eye leads to the development of accommodation paralysis, cycloplegia. Temporary paralysis of accommodation ensures the restoration of lost eye function in various diseases, and makes it possible to distinguish the normal phase from true myopia at the time of diagnosis.
Dorzopt Plus easily penetrate the conjunctiva of the eye. The active ingredient reaches its peak of pharmacological activity half an hour after instillation. The pupil remains dilated for 10 hours after instillation, in some cases more. The residual phenomenon of paresis of accommodation can persist for 24 hours after instillation. The composition has antispasmodic properties and reduces the secretion of the gastric glands. Dorzopt Plus in therapeutic doses has a stimulating effect on the nervous system. The effect of using the composition can be traced 30-60 minutes after instillation. The tool provides an increase in intraocular pressure and a decrease in the tone of the vagus nerve. Such activity leads to the development of tachycardia and a slight increase in blood pressure.
Timolol is a non-selective beta-adrenergic receptor blocker without sympathomimetic activity. When used topically, it helps to reduce the secretion of intraocular fluid and to a small extent enhances its outflow from the chambers of the eye. The component does not affect the functional state of the cardiovascular system.
Dorzolamide this compound selectively inhibits the functional activity of the enzyme carbonhydrase II, thereby reducing the production of intraocular fluid and reducing pressure.

Indications for use

The main indication for the use of Dorzopt Plus is increased intraocular pressure in open-angle glaucoma and pseudoexfoliative glaucoma with insufficient effectiveness of monotherapy.

for adults

Drops are prescribed to reduce intraocular pressure in open-angle glaucoma and intraocular hypertension in cases where monotherapy did not give the desired therapeutic effect. Dorzopt Plus is distinguished by high criteria of efficacy and safety, but it can only be used as directed by a doctor. Independent use is unacceptable due to the high risks of developing adverse reactions. In compliance with the rules of increased caution, the medication is prescribed to elderly patients. Subject to the rules of application, the probability of absorption of the substance into the systemic circulation remains minimal.

for kids

Children under the age of 18 are considered as a stable contraindication to the use of the drug Dorzopt Plus. The medicinal composition can provoke the appearance of stable deformations in the structures of the eye.

for pregnant women and during lactation

Dorzopt Plus is prohibited for use during pregnancy and breastfeeding. In some cases, when the expected benefit to the mother significantly outweighs the risks to the fetus, the composition can be used during pregnancy. The scheme of use is determined privately, and the condition of the woman must be strictly controlled.

Contraindications

The list of contraindications to the use of the drug Dorzopt Plus is quite general and includes several positions:
    Chronic obstructive pulmonary disease of severe degree.
    Sinus bradycardia.
    Increased bronchial reactivity.
    Atrioventricular block 2-3 degrees.
    Cardiogenic shock.
    Severe failure of the functional activity of the kidneys with a significant slowdown in the excretion of metabolites of active substances.
    Simultaneous use with oral dosage forms of drugs of the carbonic anhydrase inhibitors group.
    Age up to 18 years.
    Severe lack of functional activity of the heart.
    Severe allergic rhinitis.
    Angle-closure glaucoma.
    Pregnancy at any stage of the course and lactation period.
    Hyperchloremic acidosis.
    Individual intolerance to the components of Dorzopt Plus.
    Bronchial asthma.
Using the product for patients with similar conditions and disorders is dangerous. A medicinal product can cause severe adverse reactions. In some cases, the use of the drug can cause the patient to lose sight.

Applications and doses

The dosage regimen is determined privately and largely depends on the indications for use. Dorzopt Plus drops are intended for one-time instillation into the eyes, 1-2 drops. According to the instructions, if it is necessary to study the fundus, patients are prescribed 1 drop of the drug three times in the eye, with an interval of 10 minutes. For the treatment of infectious and inflammatory diseases of the eyes, use means in a dose of 1-2 drops of the drug into the conjunctival sac 4 times a day. The interval between uses must be equal. The duration of the course of treatment is about 7 days. In the absence of results or deterioration of the patient's condition, you should consult a specialist to correct the diagnosis and treatment.

for adults

The average recommended therapeutic dose is 1 drop, which is instilled into the lower conjunctival sac 2 times a day. If eye drops are used to replace another drug, then a break of 24 hours is provided beforehand.

for kids

Dorzopt Plus is prohibited for use in patients of this age group. The drug can provoke the appearance of severe adverse reactions in patients of this group. The drug formulation can cause loss of vision when used in high doses.

for pregnant women and during lactation

Women during pregnancy and lactation are not allowed to use a medication. In some cases, when the risk of vision loss by a woman exceeds the expected damage to the fetus, the composition is applied. In this case, the woman is recommended to use the medication in a limited course - this condition prevents the likelihood of adverse reactions.

Side effects

Against the background of the use of a medication, side reactions are often traced, which are expressed in the form of local changes: signs of irritation, including a burning sensation, "sand in the eyes", reddening of the cornea, inflammation of the eyelids, transient point erosion of the corneal surface, edema of corneal tissues, change in the direction of eyelash growth , which can increase eye irritation, increased iris pigmentation, eyelash changes. In patients with a predisposition to the development of allergic reactions, the following changes can be traced: attacks of bronchial asthma, which mainly develop in patients with an unfavorable history, shortness of breath. With prolonged use, patients run the risk of experiencing the following symptoms: headache of varying severity, periodic dizziness.

Interaction with other medicinal products

No targeted studies have been conducted on the possible interaction of the active components of Dorzopt Plus with drugs of other pharmacological groups. There is a possibility of changing the pharmacological effect when used simultaneously with the following medicines: adrenaline, beta-blockers.

Special instructions

Patients should pay attention to the following conditions:
    The active components of the drug do not directly affect the functional state of the cerebral cortex and other structures of the central nervous system.
    After instillation, a temporary decrease in visual acuity is possible, therefore it is recommended to abandon potentially hazardous activities (driving a car) within 15 minutes.
    It is not recommended to use the drug for the treatment of angle-closure glaucoma, the development of which requires other therapeutic approaches.
    It is not recommended to touch the tip of the dropper bottle to surrounding objects, as this significantly increases the risk of infection of the tissues of the eye structures.
    Cancellation of the drug should be carried out by gradually reducing the recommended therapeutic dose.
    The use of medication for patients with concomitant corneal defects or after undergoing surgery on the eye can lead to decompensation of its functional state and the development of severe edema.
    Long-term use of drugs containing timolol in their composition can lead to the formation of resistance.
    Patients are advised to temporarily stop wearing contact lenses, since the drug contains benzalkonium chloride, which has a negative effect on their condition. If the patient continues to wear the lenses, then they should be removed before each instillation of the drug, the reverse installation is allowed no earlier than 15 minutes later.
    If it is necessary to perform a surgical intervention, the anesthesiologist should be warned about the possible use of the drug, since correction of anesthesia may be required.
Compliance with the listed instructions ensures the correct operation of the medication.

Overdose

The likelihood of overdose symptoms in patients. The use of the formulation for instillation into the eyes remains minimal. The risk of adverse reactions increases with accidental oral administration of the medication. The patient may experience the following changes:
    dry skin and mucous membranes;
    tachycardia;
    mydriasis;
    convulsions;
    depression of consciousness, coma;
    paresis of accommodation;
    stomachache;
    headache.
Treatment begins with gastric lavage and sorbent intake. Subsequently, symptomatic treatment is carried out. It is important to take the patient to the hospital with an intense manifestation of symptoms of acute intoxication.

Storage conditions

Eye drops Dorzopt Plus should be stored in undamaged original packaging, in a dark, dry place, out of reach of children, at an air temperature of +2 to + 30 ° C. The shelf life of the medicinal product is 2 years. After opening the dropper bottle, the eye drops can be used for a month.

Terms of sell

You don't need a prescription to buy Dorzopt Plus.