Amoxiclav tabs 500mg + 125mg #15

Instruction for Amoxiclav

You can buy Amoxiclav here

Instructions for use Amoxiclav indicates the ability of the drug bactericidal and bacteriostatic effect on most gram-negative and gram-positive microorganisms.
In this article, we will consider when doctors prescribe Amoxiclav, including instructions for use, analogues and prices for this drug in pharmacies. If you have already used Amoxiclav, leave comments in the comments.

Composition and release form

Clinico-pharmacological group: an antibiotic of the broad-spectrum penicillin group with a beta-lactamase inhibitor. Release form:
    Tablets 250 + 125 mg: white or almost white, oblong, octagonal, biconvex tablets, film-coated, with impressions "250/125" on one side and "AMC" on the other side. Each tablet 250mg + 125mg contains 250 mg of amoxicillin in the form of trihydrate and 125 mg of clavulanic acid in the form of potassium salt.
    Tablets 500 + 125 mg: white or almost white, oval, biconvex tablets, film coated. Each 500mg + 125mg tablet contains 500 mg of amoxicillin in the form of trihydrate and 125 mg of clavulanic acid in the form of potassium salt.
    Tablets 875 + 125 mg: white or almost white, oblong, biconvex tablets, film-coated, with a notch and imprints "875" and "125" on one side and "AMC" on the other side. Each tablet of 875 mg + 125 mg contains 875 mg of amoxicillin in the form of a trihydrate and 125 mg of clavulanic acid in the form of a potassium salt.
Also, the tool is produced in the form of a powder from which to make a suspension, the vial contains powder for preparing 100 ml of the product.
Powder is also produced, from which a solution is made, which is injected intravenously. The bottle contains 600 mg of Amoxiclav (amoxicillin 500 mg, clavulanic acid 100 mg), 1.2 g bottles of amoxicillin 1000 mg, clavulanic acid 200 mg are also available, and 5 fl.

pharmachologic effect

Amoxiclav is a broad-spectrum antibiotic; contains semi-synthetic penicillin amoxicillin and b-lactamase inhibitor clavulanic acid. Clavulanic acid inhibits most clinically significant b-lactamases (types 2, 3, 4, and 5 according to the Richmond Sykes classification) produced by Staphylococcus spp., Escherichia coli, Proteus mirabilis, Haemophilus influenzae, Moraxella catarrhalis, Bacteroides spp. Inactive against b-lactamase type 1, produced by Enterobacter spp., Morganella morganii, Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp.

Indications for use

Amoxiclav is prescribed for infectious-inflammatory diseases that develop as a result of the influence of microorganisms sensitive to this medicine.
The following indications for the use of this drug are determined:
    infections of the upper respiratory tract and upper respiratory tract (including acute and chronic sinusitis, acute and chronic otitis media, pharyngeal abscess, tonsillitis, pharyngitis);
    lower respiratory tract infections (including acute bronchitis with bacterial superinfection, chronic bronchitis, pneumonia);
    urinary tract infections;
    gynecological infections;
    infections of the skin and soft tissues, including animal and human bites;
    infections of bone and connective tissue;
    biliary tract infections (cholecystitis, cholangitis);
    odontogenic infections.
From what helps Amoxiclav still, you should ask a specialist during an individual consultation.

Instructions for use

Amoxiclav tablets are taken orally, preferably after a meal. According to the instructions for use, the dosage depends on the severity of the infection process and the age of the patient.
Recommended dosage for pills:
    Adults and children over 12 years old (or with a body weight of> 40 kg) with a mild or moderate course of infection are prescribed 1 tab. (250 mg + 125 mg) every 8 hours or 1 tab. (500 mg + 125 mg) every 12 hours, in case of severe infection and respiratory infections - 1 tab. (500 mg + 125 mg) every 8 hours or 1 tab. (875 mg + 125 mg) every 12 hours.
    Amoxiclav in the form of tablets is not prescribed for children under 12 years old (weighing <40 kg). In this case, it is better to use the dosage form in the form of a suspension. The maximum daily dose of clavulanic acid (in the form of potassium salt) is 600 mg for adults and 10 mg / kg of body weight for children. The maximum daily dose of amoxicillin is 6 g for adults and 45 mg / kg of body weight for children.
The dosage regimen is set individually depending on the age, body weight, renal function of the patient, as well as the severity of the infection. The course of treatment is 5-14 days. The duration of treatment is determined by the attending physician. Treatment should not last more than 14 days without re-medical examination.

Contraindications

    hypersensitivity to any of the components of the drug;
    history of hypersensitivity to penicillins, cephalosporins and other beta-lactam antibiotics;
    a history of indications of cholestatic jaundice and / or other abnormalities in liver function caused by taking amoxicillin / clavulanic acid;
    infectious mononucleosis and lymphocytic leukemia.
Precautions should be prescribed Amoxiclav for allergic reactions to cephalosporins and pseudomembranous colitis in history, liver failure, severe renal impairment.

Side effects of Amoxiclav

Side effects are usually temporary and mild.
    On the part of the digestive system: possible loss of appetite, nausea, vomiting, diarrhea; rarely, transient increases in liver enzymes (ALT, AST), abnormal liver function; in rare cases, cholestatic jaundice, hepatitis, pseudomembranous colitis.
    On the part of the nervous system: rarely - agitation, anxiety, headache, dizziness, inappropriate behavior, insomnia, convulsions, confusion, hyperactivity.
    On the part of the blood system: thrombocytopenia, anemia (including cases of hemolytic anemia), leukopenia, eosinophilia, agranulocytosis.
    Allergic reactions: erythematous rash, pruritus, urticaria; rarely, exudative erythema multiforme, angioedema, and anaphylactic shock; in rare cases - exfoliative dermatitis, Stevens-Johnson syndrome.
    Hepatobiliary disorders: it is possible to increase the parameters of liver function tests, including an increase in the activity (asymptomatic) of AlAT and / or AcAT, alkaline phosphatase and serum bilirubin levels. Liver dysfunction usually develops in elderly patients or in patients who have been prescribed long-term drug therapy. Hepatitis and cholestatic jaundice are quite rare.
    On the part of the urinary system: hematuria and interstitial nephritis (rare).
Other: rarely - the development of superinfection (including candidiasis); reversible increase in prothrombin time (when used together with anticoagulants).

Overdose

There are no reports of death or life-threatening side effects due to overdose of Amoxiclav.
In most cases, overdose symptoms include gastrointestinal disorders (abdominal pain, diarrhea, vomiting). It is also possible anxiety, insomnia, dizziness, in rare cases - convulsive seizures.
In case of overdose, the patient should be under the supervision of a physician, treatment is symptomatic. In the case of a recent intake (less than 4 hours), it is necessary to conduct a gastric lavage and to appoint activated charcoal to reduce absorption.

special instructions

Due to the fact that a large number of patients with infectious mononucleosis and lymphocytic leukemia who received ampicillin, the appearance of an erythematous rash was observed, the use of ampicillin antibiotics for these patients is not recommended.
    Since tablets of amoxicillin and clavulanic acid 250 mg + 125 mg and 500 mg + 125 mg tablets contain the same amount of clavulanic acid - 125 mg, 2 tablets of 250 mg + 125 mg are not equivalent to 1 tablet of 500 mg + 125 mg.
In the course of treatment should be controlled by the function of blood, liver and kidneys. Patients with severe impaired renal function require an adequate correction of the dosing regimen or an increase in the intervals between dosing. In order to reduce the risk of adverse reactions from the gastrointestinal tract should take Amoxiclav during meals.

Storage conditions

In a dry place at a temperature not higher than 25 ° C. Keep out of the reach of children.

Reviews

Varvara
In fact, if amoxiclav is chosen correctly and used in combination with other drugs and physio, it can solve many serious problems. The husband took him for prostatitis, while he was treated with other drugs and smartprost, the effect was excellent - he didn’t remember about his illness for more than a year and a half. But he was prescribed amoxiclav after sowing for sensitivity.

Terms of sell

You don't need a prescription to buy Amoxiclav.