Zodac tabs 10mg #30

Zodac user manual

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In this article, you can read the instructions for use of the drug Zodac. Use for the treatment of allergies, rhinitis and conjunctivitis in adults, children, as well as during pregnancy and lactation. The composition and interaction of the drug with alcohol.
Zodac - antiallergic drug, histamine H1-receptor blocker. Cetirizine belongs to the group of competitive histamine antagonists. It has a pronounced antiallergic effect, prevents the development and facilitates the course of allergic reactions. It has antipruritic and antiexudative effect. Affects the early stage of allergic reactions, and also reduces the migration of inflammatory cells; inhibits the release of mediators involved in the late allergic reaction. Reduces capillary permeability, prevents the development of tissue edema, relieves smooth muscle spasm. Eliminates skin reactions to the introduction of histamine, specific allergens, as well as cooling (with cold urticaria).
Practically no anticholinergic and antiserotonin action.
In therapeutic doses, almost no sedative effect. Against the background of admission course tolerance does not develop.
The effect of the drug begins after 20 minutes (in 50% of patients) or after 1 hour (in 95% of patients) and lasts for 24 hours.

Composition

Cetirizine dihydrochloride + excipients.

Pharmacokinetics

After ingestion Zodac quickly and almost completely absorbed from the gastrointestinal tract. Food intake does not have a significant effect on the amount of absorption, however, in this case, the absorption rate decreases slightly. Cetirizine does not penetrate inside the cell. Does not penetrate the hematoencephalic barrier (BBB). Cetirizine is poorly metabolized in the liver to form an inactive metabolite. About 70% is excreted by the kidneys mostly unchanged.

Indications for Zodac

    seasonal and year-round allergic rhinitis and conjunctivitis;
    pruritic allergic dermatosis;
    pollinosis (hay fever);
    urticaria (including chronic idiopathic);
    Quincke swelling.

Forms of release

10 mg coated tablets.
Drops for oral administration.
Syrup.

Instructions for use and dosage

The drug Zodac is prescribed by a doctor in order to avoid complications.
Inside, regardless of the meal.

Adults and children over the age of 12

The drug Zodac, usually prescribed by 1 tablet, coated (10 mg cetirizine) 1 time per day.

Children aged 6 to 12 years

The drug Zodac is usually prescribed 1 tablet, coated (10 mg cetirizine) 1 time per day or 1/2 tablet, coated, 5 mg cetirizine) 2 times a day, morning and evening.

Side effect

    dry mouth;
    dyspepsia;
    headache;
    drowsiness;
    fatigue;
    dizziness;
    excitation;
    migraine;
    skin rash;
    angioedema;
    hives;
    pruritus

Contraindications for Zodac

    pregnancy;
    lactation period;
    children's age up to 1 year (drops for oral administration);
    children's age up to 2 years (syrup);
    hypersensitivity to the drug.

Use during pregnancy and lactation

Zodac is contraindicated in pregnancy and lactation.

special instructions

Not recommended simultaneous medications that have a depressant effect on the central nervous system, and alcohol consumption.
Strengthens (mutually) deprimation and decrease in the rate of psychomotor reactions when using ethanol (alcohol); At the time of treatment it is necessary to abandon alcoholic beverages.
Drops for oral administration do not contain sugar (saccharin is used as a sweetener), so this dosage form can be administered to patients with diabetes mellitus.
10 ml of syrup (2 scoops) contains 3 g of sorbitol, which corresponds to 0.25 XE.

Influence on ability to drive motor transport and control mechanisms

During the period of treatment, it is necessary to refrain from engaging in potentially hazardous activities that require increased concentration of attention and quickness of psychomotor reactions.

Drug interactions

Not established clinically significant interaction Zodac with other drugs.
Combined use with theophylline (400 mg per day) leads to a decrease in the total clearance of cetirizine (the kinetics of theophylline does not change).

Release form, composition and packaging

Tablets, film-coated white or almost white, oblong, with a risk for dividing on one side.
Excipients: lactose monohydrate - 73.4 mg, corn starch - 33 mg, povidone 30 - 2.4 mg, magnesium stearate - 1.2 mg.
The composition of the shell: hypromellose 2910/5 - 3.45 mg, macrogol 6000 - 0.35 mg, talc - 0.35 mg, titanium dioxide - 0.80 mg, simethicone emulsion SE4 - 0.05 mg.

How does it work

Zodac (cetirizine - chemical and international name) is a second generation antiallergic drug that has a prolonged effect.
Produced in the Czech Republic (Zentiva Ltd.).
Medicine:
    affects the early and late cellular phases of allergic reactions;
    interferes with the release of histamine from basophilic leukocytes and fat cells;
    reduces the migration of inflammatory cells, in particular, eosinophils.
By taking the drug is prevented:
    development of tissue edema;
    smooth muscle spasm is removed;
    capillary permeability decreases.
The reaction of the skin to the introduction of allergens, histamine, to cooling (in the case of cold urticaria) is also eliminated.
The drug is effective for itching, has antiexudative effect.
Antiserotoninovogo and anticholinergic (the ability of brain cells to transmit nerve signals) the drug has no effect.
    In therapeutic doses, it practically does not give a hypnotic effect.
During the course taking habituation does not develop.
The effect of the drug in 50% of patients begins in about 20 minutes, in 95% of patients in one hour and lasts for a day.
After taking all the substances of the drug are absorbed quickly and almost completely.
The final half-life of the drug is approximately 10 hours, about 70% of the drug is evacuated through the kidneys unchanged.
The amount of absorption (absorption) does not have a significant impact on food intake, however, the absorption rate of the drug decreases somewhat.
After applying daily therapeutic doses of the drug for 10 days, no accumulation of cetirizine was observed in the body.

Terms of sell

You can buy Zodac without a prescription.