Zodac drops 10mg/ml 20ml

Zodac drops instruction

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Cetirizine Allergy Drops. Children's form of release makes it possible to apply Zodac from 2 years of age. When used correctly, side effects are extremely rare. The drug effectively relieves itching and swelling. The body does not accumulate. A single dosage and frequency of administration are determined by the doctor. May cause side effects from other organs and systems.

Dosage Form

Drops are sold in bottles of dark brown glass with a capacity of 20 ml. 1 ml of liquid contains 10 mg of active active ingredient. The bottle is sealed with a plastic dropper cap for ease of dispensing the drug. The cover has a mechanism for protection against opening by children. To open the bottle, press the plastic cover and turn it counterclockwise. After use, the bottle is firmly twisted clockwise.

Description and composition

Drops for children Zodac are produced by the pharmaceutical company Zentiva, the country of origin is the Czech Republic. The active ingredient of the drug is cetirizine dihydrochloride, which is a selective 2 generation H1-histamine peripheral receptor blocker. The substance does not have significant anthoholergic and antiserotonin action, which makes the drug more effective and safe for administration in childhood compared with the first generation of antihistamines.
Auxiliary medicinal substances: purified water, glycerol, methyl parahydroxybenzoate, sodium saccharinate dihydrate, glacial acetic acid, propyl parahydroxybenzoate, sodium acetate trihydrate, propylene glycol. Additional substances are needed to create a convenient dosage form, extend the maximum shelf life, increase the effectiveness of the active substance in the preparation.

Pharmacological group

Drops for children Zodac belong to the antihistamine group of drugs of the 2nd generation.

Pharmacodynamics

The active active ingredient - cetirizine dihydrochloride selectively blocks peripheral H1-histamine receptors and competes with the effects of histamine. This leads to the elimination of allergic reactions in the body and improve the overall condition. The drug reduces the activity of eosinophils and basophils in the skin and mucous membranes, which prevents allergic damage to the eyes, upper respiratory tract, and skin.
In therapeutic age doses, Zodac drops prevents the development of seasonal and atopic rhinitis, conjunctivitis, asthma, urticaria, allergic dermatitis, eczema. Cetirizine has anti-edema and anti-inflammatory effect, improves airway patency, reduces the formation of inflammatory discharge from the nose and eyes, prevents skin rash, soothes itching and sverbeniya.

Pharmacokinetics

Drops Zodac designed for oral administration. After entering the digestive tract, the drug is absorbed in the stomach, penetrates the general bloodstream (systemic action), is associated with 93% of blood transport proteins. In clinical trials, no effect of cetirizine on warfarin with transport albumin was detected. The maximum concentration of the drug in the blood plasma is reached in 30-90 minutes. The rate of absorption is affected by the use of drops with food. Reception at mealtime lengthens the rate of absorption, but does not affect the concentration of the drug in the blood plasma.
Cetirizine for the most part is not metabolized in the liver. The drug is excreted by the kidneys by 2/3 unchanged. Accumulation of cetirizine in the body was not detected. Disruption of the pharmacokinetics of the drug develops in renal failure. With creatinine clearance less than 10 ml / minute, cetirizine is not excreted and has a toxic effect on organs and tissues. The half-life of the drug from the body in children is 3 hours, in adults an average of 10 hours.

Indications for use

Drops for children Zodac prescribes a doctor after examining a child and conducting additional methods of diagnosis. The drug is used in allergic conditions of a seasonal intermittent (during the flowering of plants) or persistent (in contact with an allergen throughout the year) nature.

Indications for prescribing Zodac drops:

    allergic rhinitis (sverbeniya and itching in the nose, mucous discharge from the nasal passages, sneezing);
    allergic conjunctivitis (redness of the mucous membranes of the eyes, itching, tearing, photophobia);
    allergic rash (urticaria, dermatitis, eczema);
    bronchial asthma (shortness of breath, unproductive cough, feeling of lack of air, wheezing in the lungs);
    idiopathic urticaria (skin lesions and fever).
Zodac Drops are effective and safe for use in children 1 year and older.

Contraindications

Drops Zodac have a small list of contraindications. The effectiveness of the action determines the dose and frequency of medication, the duration of the course of therapy.
Contraindications for prescribing Zodac drops:
    increased individual sensitivity to cetirizine, hydroxysin (the substance from which cetirizine is synthesized), preparation auxiliary substances;
    severe renal failure with creatinine clearance less than 10 ml / minute;
    chest age (up to 1 year).
In other cases, the drug is prescribed under the supervision of a physician in age dosages.

Dosage and administration

Drops Zodac used to eliminate allergic reactions in the body. For children over 12 years old and adult patients, 20 drops of the drug (10 mg) are administered once a day, 10–20 drops (5 mg) for children from 6–12 years old, 5 drops for children from 2 to 6 years of age (2, 5 mg twice a day; children from 1 to 2 years old - 5 drops (2.5 mg) once.
Drops with large dosages dissolved with a third cup of boiled water. In small dosages for children under 6 years old, the drops are dissolved in a tablespoon or a teaspoon of boiled water, depending on how much the child can drink once.

Side effects

Taking Zodac drops in recommended age doses rarely leads to side effects. Despite the fact that cimetidine dihydrochloride selectively blocks the H1-histamine receptors and practically does not penetrate the blood-brain barrier, sometimes undesirable consequences arise from the central nervous system (central nervous system). Rapid fatigue, drowsiness, headache, dizziness, periods of mental arousal appear.
Strengthening the anticholinergic effect causes impaired urination and urinary retention, deterioration of the accommodation process (ability to focus eyesight), dryness in the oral cavity. Side effects from the liver are manifested by an increase in blood concentrations of bilirubin and liver enzymes. These indicators are normalized after discontinuation of the drug. Register nausea, single vomiting, pain in the abdomen. Rarely children develop medicinal pharyngitis.

Interaction with other drugs

In clinical studies, no negative interaction of cimetidine with other drugs was detected. Do not recommend taking several drugs with antihistamine action without a prescription.

Overdose

A clinically significant overdose is recorded when the therapeutic dose is exceeded 5 or more times. On the background of an overdose, pathological symptoms of the central nervous system develop: anxiety becomes replaced by drowsiness, stupor, hand tremor, headache, confusion. On the part of the digestive system, there is spasmodic pain in the abdomen and diarrhea, on the part of the cardiovascular system, tachycardia (increased heart rate), urination — urinary retention. In case of overdose, gastric lavage is performed, symptomatic therapy is prescribed. Zodac drops do not have an antidote (a substance that levels the negative effect of the drug).

Storage conditions

Drops Zodac must be stored in a dark cool place at a temperature not higher than 20 degrees. The drug should be hidden from children in order to avoid poisoning, the cover with a protective mechanism should be closed until it clicks. Shelf life - 3 years. After the expiration date of the drug is contraindicated for use.

Terms of sell

You don't need a prescription to buy Zodac drops.