Nise tabs 100mg #30

User manual for Nise

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The main applications of Nise are the therapy of osteoarthritis and osteoarthritis, as well as the relief of pain syndrome of various etiologies and localization (for example, trauma, toothache, menstrual pain, diseases of the ear, throat, nose, etc.) and a decrease in body temperature during infections.

Release form and composition

The main component of the drug is nimesulide. It has good absorption, its maximum amount is manifested in the blood after 1-2 hours. Excreted almost completely through the bile and kidneys.
Also, the drug includes additional elements:
    calcium phosphate;
    cellulose;
    starch (usually corn);
    talc;
    magnesium stearate;
    flavorings;
    aspartame;
    sodium glycolate;
    silica (colloidal).
Nise is a convex tablet, round on both sides, containing 100 mg of the main element. One blister consists of 10 pieces. It can also be produced in the form of granules for suspension, ointment or gel. All types of medicines stacked in cardboard packaging.

Pharmacological effect

Nimesulide (active ingredient) has anti-inflammatory, antipyretic and analgesic effects on the human body.
Nise is effective in diseases associated with inflammation, pain and swelling. It inhibits platelet aggregation, and also significantly reduces bronchospasm, which is triggered by the action of acetaldehyde and histamine. In addition, Nise slows down the formation of toxins and has an antioxidant effect.
When applied topically, the gel reduces morning stiffness, relieves swelling and reduces pain in the joints.

Indications for use

What does Nise help? There are a lot of reasons for prescribing the drug. The most common:
    radiculitis;
    osteochondrosis;
    sharp lower back pain;
    ankylosing spondylitis;
    high temperature;
    joint damage from rheumatism;
    rheumatoid arthritis (as well as psoriatic and other types);
    exacerbation of gout;
    muscle and joint pain;
    bursitis (inflammation of the mucous bags, often in the joints);
    inflammatory processes of various origins;
    pains: headache, toothache, menstrual.

Contraindications

Before starting drug therapy, you should carefully read the enclosed instructions. Nise tablets are contraindicated in patients with the following conditions:
    Aspirin Triad;
    Individual intolerance to the medicinal composition;
    Pregnancy and breastfeeding period;
    Chronic erosive processes in the digestive tract organs during the period of exacerbation;
    Gastrointestinal bleeding or suspicion of it;
    Severe liver and kidney function;
    Acute hepatic or renal failure;
    Children up to 12 years of age for this dosage form;
    Atopic dermatitis or bronchial asthma.
With caution, the drug Nise prescribed to patients with hypertension and type 2 diabetes.

Use during pregnancy and lactation

Nise can have a negative impact on fertility, pregnancy and fetal development, so the drug is not recommended for use during the entire period of childbearing, as well as at the planning stage of pregnancy.
It is also contraindicated to use Nise during breastfeeding, since it is not known whether the drug is excreted into milk.

Dosage and method of use

The instructions for use indicate that the tablets Nise should be used in the minimum effective dose of the minimum possible short course. Tablets are taken with a sufficient amount of water, preferably after meals. In the presence of gastrointestinal diseases, it is desirable to take the drug at the end of a meal or after a meal.
    Adults and children over 12 years old - inside by 1 tab. 2 times / day. The maximum daily intake for adults is 200 mg.
Patients with chronic renal failure require a reduction in the daily dose to 100 mg.

Side effects

According to reviews Nise when ingested can cause the following side effects:
    Headache and dizziness;
    Anaphylactic shock, skin rash or bronchospasm;
    Fluid retention, hematuria, lengthening of bleeding time;
    Heartburn, nausea and vomiting, stomach pain, erosive and ulcerative lesions of the gastrointestinal tract, diarrhea, increased activity of hepatic transaminases and toxic hepatitis;
    Leukopenia, thrombocytopenia, anemia or agranulocytosis.

Overdose

An overdose of Nise can lead to severe consequences and is accompanied by impaired renal function, liver failure, seizures, high blood pressure, respiratory depression, drowsiness and apathy. Sometimes the position of the patient is aggravated by the development of gastrointestinal bleeding. In case of an overdose of a patient, a hospital is sent, where they do gastric lavage, prescribe sorbents (Enterosgel, Polysorb, Polypefan) and osmotic laxatives.
In order to prevent overdose, you should strictly follow the instructions to the drug and not exceed the maximum allowable daily doses. The doctor should count the dose of medicine for the child, taking into account body weight, age, severity of symptoms and other individual characteristics.

special instructions for Nise

Before you start using the drug, read the specific instructions:
    The drug is contraindicated in children under the age of 12 years.
    After 2 weeks of use of the drug, control of biochemical parameters of liver function is necessary.
    Considering reports of visual impairment in patients taking other NSAIDs, treatment should be stopped immediately if any visual impairment occurs and the eye doctor should examine the patient.
    Since nimesulide is partially excreted by the kidneys, its dose for patients with impaired renal function should be reduced, depending on the value of QC.
    Regular medical supervision is required if the patient, along with nimesulide, takes medications that are characterized by an effect on the gastrointestinal tract.
    The drug can cause fluid retention in the tissues, so for patients with high blood pressure and with impaired cardiac activity, nise should be used with extreme caution.
    Do not use the drug at the same time as other NSAIDs.
    If there are signs of liver damage (skin itching, yellowness of the skin, nausea, vomiting, abdominal pain, dark urine, increased activity of hepatic transaminases), you should stop taking the drug and contact your doctor.
    The drug can change the properties of platelets, but does not replace the prophylactic action of acetylsalicylic acid in cardiovascular diseases.
The drug can cause drowsiness, dizziness and blurred vision, so care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and psychomotor speed.

Drug interactions

When using the drug, you must consider the interaction with other drugs:
    Nimesulide can reduce the effects of furosemide.
    Nimesulide may enhance the effect of cyclosporine on the kidneys.
    The concentration of lithium in the plasma increases while taking drugs of lithium and nimesulide.
    Nimesulide may increase the possibility of adverse reactions while taking methotrexate.
    Due to the high degree of nimesulide binding to plasma proteins, patients who are simultaneously treated with hydantoin and sulfonamides should be under the supervision of a physician, undergoing examination over short periods of time.
    The action of drugs that reduce blood clotting, increases with their simultaneous use with nimesulide.
    With simultaneous use with GCS, serotonin reuptake inhibitors increases the risk of gastrointestinal bleeding.

Reviews

We picked up some reviews of people using the drug Nise:
Egor
    I sit at the computer a lot. Earned carpal tunnel syndrome. When the unbearable accept Nimesan. Hands stop hurting after three minutes, and you can continue.
Nastya
    “Nise” is used for severe pains, my family is “familiar” with him firsthand. It was first used when a wisdom tooth was removed. The result is excellent and the effect lasts for a long time. One day she could not take the pill on time, the pain began to roll in waves. I heard that it is much more difficult to cope with sore pain, but nise helped quite quickly. Still rare, but I take with a strong headache when citramon does not help. And the last time my husband had shot her back, the pain was very strong - I could not get up. Also, first of all, she gave him a “Nise”, and after that she rubbed her back.
Valentine
    During menstruation, I did not know where to put myself. I tried a lot of drugs. They gave effect, but not the way I would like, and after a while the pain started again. Somehow going to the pharmacy, I did not find those painkillers that I had always taken. The pharmacist advised to take Nise. There was nowhere to go, and I agreed. But I do not regret my purchase. I also waited for such result from other tablets.

Storage conditions

Store the tool at home in a place where there is no high humidity, at a temperature not exceeding 25 ° C. Protect the storage place from bright sunlight.
Shelf life of the drug is not more than 3 years. Use after the expiration of these terms is prohibited.

Terms of sell

You don't need a prescription to buy Nise.