Nimesulide tabs 100mg #20

Nimesulide instruction

You can buy Nimesulide here

Release form and composition

Nimesulide is available in the following forms:
    Tablets (10 pieces in a blister; 1,2 or 3 blisters per pack);
    Suspension for oral administration (60 ml vial);
    Gel 0.1%: homogeneous, transparent or almost transparent, yellow (30 g in a tube, 1 tube in a carton box);
    Powder for the preparation of suspensions: from white to white with a yellowish tinge, when dissolved forms a suspension of white or light yellow color with a characteristic lemon smell (2 g per bag; 9 or 30 bags per pack).
Active ingredient: nimesulide (100 mg in 1 tablet; 50 mg in 1 g of powder; 10 mg in 1 ml of suspension; 10 mg in 1 g of gel).
Auxiliary components:
    Tablets: lactose monohydrate, microcrystalline cellulose, magnesium stearate, sodium croscarmellose, calcium hydrogen phosphate dihydrate, sodium lauryl sulfate, talc, hydroxypropylcellulose, aerosil;
    Gel: macrogol 400, carbomer, dimexide, propylene glycol, ethyl alcohol.

Pharmacological effect

imesulide has a pronounced anti-inflammatory, as well as moderate analgesic and mild antipyretic effect. The drug is a selective inhibitor of cyclooxygenase-2.
Thus, the mechanism of the anti-inflammatory action of the drug is based on the inhibition of prostaglandin synthesis: the active substance of the drug inhibits mainly cyclooxygenase-2, due to which prostaglandin synthesis is inhibited mainly in the area of ​​inflammation and to a lesser extent in the kidneys and gastric mucosa.
The maximum concentration of the drug in the blood plasma is achieved one to two hours after ingestion of a suspension or tablets of Nimesulide. From the body the drug is almost completely excreted within 24 hours. With long-term use of Nimesulide accumulation (accumulation) of the drug is not observed.

Indications for use

Nonsteroid drug against inflammation is a great way to quickly get rid of pain, swelling inside the body. It is important to understand that the medicine with nimesulide will relieve you from the symptoms of the disease, but it will not eliminate the ailment itself. According to the instructions for use, the substance has three main areas of work:
    anti-inflammatory effect;
    elimination of heat;
    anesthesia.
The drug has received a large number of positive reviews and is actively used in medicine. If you do not know what helps nimesulide from, read this list:
    osteochondrosis;
    tendon inflammation;
    rheumatism;
    problems of the musculoskeletal system;
    muscle pain.

Contraindications

According to the instructions to Nimesulide, it should not be taken in such cases:
    Pregnancy;
    Lactation;
    Children's age up to 12 years;
    Bleeding, including cerebrovascular;
    Active gastrointestinal bleeding;
    Confirmed hyperkalemia;
    Severe chronic renal failure (creatinine clearance <30 ml / minute);
    Alcoholism or drug addiction;
    The simultaneous appointment of other hepatotoxic drugs;
    Hepatotoxic reactions in the application of nimesulide in history;
    Erosive and ulcerative lesions of the gastric mucosa and duodenum;
    Exacerbation of inflammatory bowel disease (Crohn's disease or ulcerative colitis);
    Decompensated chronic heart failure;
    The period after coronary artery bypass surgery;
    Any active or progressive liver disease, liver failure;
    Blood clotting disorders, incl. hemophilia;
    Hypersensitivity to the drug;
    A complete or incomplete combination of bronchial asthma and recurrent nasal polyposis / paranasal sinuses with intolerance to acetylsalicylic acid or other NSAIDs (including a history of).
Relative contraindications:
    Dyslipidemia and hyperlipidemia;
    Creatinine clearance <30-60 ml / minute;
    Smoking;
    The presence of Helicobacter pylori infection;
    Ulcer lesion of the gastrointestinal tract in history;
    Chronic heart failure;
    Cerebrovascular diseases;
    Coronary heart disease;
    Peripheral artery diseases;
    Diabetes;
    Severe somatic diseases;
    Elderly age;
The simultaneous use of the following drugs: anticoagulants (including warfarin), antiplatelet agents (including acetylsalicylic acid and clopidogrel), oral glucocorticosteroids, selective serotonin reuptake inhibitors (including paroxetine, citalopram, sertralin, fluoxetine).

Use during pregnancy and lactation

Nimesulide should not be taken during pregnancy. Its use is most dangerous in the third trimester of pregnancy due to the possible atony of the uterus in a woman and the premature closure of the batal's duct in a child.
During the lactation period, the drug can be prescribed only if the breastfeeding is discontinued for the period of treatment.

Dosage and method of use

The instructions for use indicate that Nimesulide is taken orally.
Nimesulide tablets are intended for ingestion in adults and adolescents over 12 years of age. It is advisable to take them after a meal, whole, without chewing and drinking plenty of water.
    The average recommended therapeutic dosage is 1 tablet 2 times a day. The maximum daily dosage should not exceed 200 mg.
The recommended duration of the course of therapy should not exceed 10 days. If necessary, the dosage and duration of administration of Nimesulide tablets is determined by the attending physician individually.

Side effects

During the use of Nimesulide, disturbances are observed on the part of some body systems that manifest themselves with different frequencies (≥1 / 10 - very often;> 1/100, <1/10 - often;> 1/1000, <1/100 - infrequently; > 1/10 000, <1/1000 - rarely; <1/10 000, including individual messages - very rarely):
    Cardiovascular system: infrequently - hypertension; rarely - palpitations, tachycardia;
    Allergic reactions: rarely - skin rash and itching; rarely - rash, erythema; very rarely - severe skin events, including toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, anaphylactic shock, bronchospasm;
    Gastrointestinal tract: often - heartburn, vomiting, nausea, diarrhea; infrequently - abdominal distension, constipation, gastritis; very rarely - ulceration of the gastrointestinal mucosa, stomach pain, melena, tarry stools, increased activity of hepatic transaminases, toxic hepatitis (including fatal outcome);
    Nervous system: infrequently - dizziness; rarely - irritability, sleep disturbance, anxiety; very rarely - encephalopathy, headache, Reine syndrome, drowsiness;
    Blood and lymphatic system: rarely - eosinophilia, anemia, prolonged bleeding time; very rarely - agranulocytosis, thrombocytopenia, purpura, pancytopenia;
    Kidneys and urinary tract: rarely - hematuria, dysuria, fluid retention; very rarely - renal failure, oliguria, interstitial nephritis;
    Other: Infrequent - swelling; rarely - hyperkalemia, asthenia, vertigo, visual impairment, malaise; very rarely - hypothermia.
With the development of any of the described side effects, as well as in cases of other violations, it is necessary to consult a doctor.

Overdose

Overdose can cause nausea and vomiting, epigastric pain and gastrointestinal bleeding, drowsiness and lethargy, arterial hypertension and acute renal failure, respiratory depression and anaphylactic reactions up to shock and coma.
There is no specific antidote. In case of overdose of Nimesulide, victims are prescribed exclusively symptomatic treatment: gastric lavage and taking activated carbon or other adsorbents for the first four hours. Hemodialysis is not performed because it is not effective.

special instructions

Before you start using the drug, read the specific instructions:
    In case of deterioration in renal function, the drug should be discontinued.
    It is necessary to stop taking the drug in case of fever or the development of flu-like symptoms on the background of his reception.
    If the drug is used for more than 2 weeks, monitoring of liver function indicators is necessary.
    To reduce the risk of side effects, it is necessary to use the drug in the lowest effective dose with the shortest duration. If the patient’s condition does not improve, treatment should be stopped.
    Gastrointestinal bleeding or an ulcer / perforation of the stomach or duodenum may develop at any time with the use of the drug, which may not be accompanied by clinically pronounced symptoms (including pain syndrome). If gastrointestinal bleeding or ulceration occurs, the drug should be withdrawn.
    In patients with cirrhosis of the liver or with renal insufficiency with hypoalbuminemia or hyperbilirubinemia, the binding of nimesulide is reduced.
    When patients taking Nimesulide, symptoms that indicate liver damage (for example, anorexia, nausea, vomiting, abdominal pain, fatigue, dark urine), or increased liver transaminases, should be discontinued. It is not recommended to appoint Nimesulide in such patients in the future.
    Elderly patients most often develop side effects when taking the drug, including gastrointestinal bleeding, perforation, impaired function of the heart, kidneys and liver. Therefore, regular clinical monitoring of the patient’s condition is recommended.
    The use of nimesulide may adversely affect female fertility and is not recommended for women planning a pregnancy.

Drug interactions

When using the drug, you must consider the interaction with other drugs:
    Nimesulide can replace salicylic acid and furosemide (but not warfarin) in plasma proteins.
    There is evidence that nimesulide may reduce the bioavailability of furosemide, to compete in the binding of plasma proteins with fenofibrate, salicylic acid, tolbutamide.
    It is not recommended to take nimesulide simultaneously with diuretics, which have a damaging effect on renal hemodynamics.
    Physiological concentrations of unsaturated fatty acids do not affect the binding of nimesulide to serum albumin.
    Taking nimesulide in therapeutic doses orally for a short period does not change the serum profile of digoxin in patients with mild heart failure.
    At therapeutic concentrations, the binding of nimesulide was not affected by warfarin, furosemide, glibenclamide, digitoxin.
    In the presence of nimesulide, the free fractions of methotrexate can significantly increase.
    The concentration of lithium in the plasma increases while taking drugs of lithium and nimesulide. Nimesulide may enhance the effect of cyclosporine on the kidneys.
    It has no effect on drugs that affect blood glucose concentration and glucose tolerance in diabetic patients treated with various drugs containing sulfonylureas.
    Use with GCS, serotonin reuptake inhibitors increases the risk of gastrointestinal bleeding.

Reviews

We picked up some reviews of people using the drug Nimesulide:
Katerina
    Nimesulide is an anesthetic and anti-inflammatory drug, so that it helps, you need to take it not once, but for some time — if sciatica (I have three hernias) - after 2-3 days of nimesulide, the effect comes, toothache - depending on what of severity: after the removal of the tooth and implantation, I was able to partially relieve pain immediately after surgery and completely relieve pain a week after surgery. A headache - to whom how, and despite what kind of pain (muscle spasm — tension headache — will help in an hour and a half, if the headache is caused by something else, it may not help, you need another drug). Therefore, it is important to know what you are treating, and what specific drug it heals, and everything will be cured in the end. And do not write that does not help - even as it helps!
Olga
    Excellent medicine "from everything". I think that should be in the first aid kit. We use it with the whole family for a couple of years. Perfect for pain or at temperature. When I'm sick, I dissolve 1 pack of powder in a half-glass of water, drink it overnight, sweat well under a warm blanket, and the temperature drops in the morning, and the headache goes away. I also use “Nimesulide” for headaches. I take in pill or powder form. I think one of the big advantages is that this medicine is universal and inexpensive, so it can be used for different symptoms.
Nastya
    I used to buy Nise, but then I chose a domestic analogue, Nimesulide, for reviews. It also helps very well, but it costs 3 times cheaper. Excellent after surgery. Stitches do not hurt at all. All night you can sleep peacefully. It is a pity that the drug has many contraindications, so you need to strictly follow the instructions for use.

Storage conditions

Store in a dark, dry place inaccessible to children at temperature up to 25 ° C.
Shelf life - 2 years.

Terms of sell

You don't need a prescription to buy Nimesulide.