Hepa-Merz granules #30

Instruction for Hepa-Merz

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Hepa-Merz is a hypoammonemic drug for the treatment of diseases of the liver and biliary tract.

Release form and composition

Granules for preparing a solution for oral administration: a mixture of granules of white and orange color (5 g each in sachets, in a cardboard box of 10 or 30 sachets);
Active ingredient - L-ornithine L-aspartate:
    1 sachet - 3 g.
Excipients:
orange flavor, anhydrous citric acid, sodium saccharinate (sodium saccharin), lemon flavor, sodium cyclamate, polyvinylpyrrolidone (povidone), sunset yellow colorant, fructose (levulose).

Pharmacodynamics

Hepa-Merz is characterized by a detoxifying effect, reducing the increased concentration of ammonia in the body. In particular, this condition occurs with liver diseases. L-ornithine-L-aspartate is involved in the ornithine Krebs urea cycle (helps to activate the cycle, increasing the activity of liver cell enzymes - carbamoyl phosphate synthetase and ornithine-carbamoyl transferase).
The drug improves the production of growth hormone and insulin, normalizes protein metabolism in diseases that require parenteral nutrition. The active component of Hepa-Merz reduces pain, dyspeptic and asthenic syndromes, and also provides a decrease in increased body weight (with steatohepatitis and steatosis).

Pharmacokinetics

L-ornithine-L-aspartate undergoes rapid dissociation into aspartate and ornithine. The drug begins to act within 15-25 minutes after administration and has a short half-life. The active substance is excreted in the urine during the implementation of the urea cycle.

Indications for use

    Chronic and acute liver diseases accompanied by hyperammonemia;
    Latent or severe hepatic encephalopathy.
In addition, the use of the concentrate is indicated as part of complex therapy for severe hepatic encephalopathy in patients with precoma or coma, and as a corrective supplement to parenteral nutrition agents for protein deficiency.

Contraindications

    Severe renal failure (creatinine level 3 mg / 100 ml);
    Period of breastfeeding;
    Hypersensitivity to the components of the drug.
According to the instructions, Hepa-Merz in granules is prescribed with caution during pregnancy.

Instructions for use Hepa-Merz: method and dosage

    Granules are taken orally, after eating, dissolving in a liquid - 1 sachet per 200 ml, 2-3 times a day.

Side effects

    Digestive system: in some cases - vomiting, nausea;
    Other: allergic reactions.

Overdose

When taking Hepa-Merz in doses significantly higher than therapeutic, it is possible to increase the severity of side effects of the drug. In this case, the stomach is immediately washed, and activated charcoal and symptomatic therapy are prescribed.

Special instructions

In case of nausea or vomiting, the rate of administration of the drug should be reduced.
Patients diagnosed with hepatic encephalopathy should be careful when engaging in potentially dangerous activities, the implementation of which requires concentration and speed of psychomotor reactions, including when driving vehicles.

Drug interaction

There is no evidence of a clinically significant drug interaction.

Terms and conditions of storage

Keep out of the reach of children. Store at temperatures up to 25 ° C.
Shelf life is 5 years.

Reviews on Hepa Merz

According to reviews, Hepa-Merz is a fairly effective drug with very few contraindications. People taking it note that adverse reactions during treatment are extremely rare, which makes the drug suitable for a wide range of patients, including children and elderly patients. However, the cost of the Hepa-Merz is quite high.
 After the operation, a course of antibiotics was prescribed. Strong urticaria began on them, and the doctor, in combination with other medicines, prescribed Hepa-Merz 1 sachet 3 times a day, course 2 weeks. After the first dose, the rash began to pass. In addition, my face turned yellow against the background of antibiotic treatment, after several days of taking the granulate, the skin became normal color. After completing the course of treatment, the doctor ordered to be tested to evaluate the liver. According to their results, it was evident that the condition of the organ improved. Granules need to be diluted in water, an orange solution is obtained that tastes good, it is easy to drink. Of the disadvantages of the drug, a high price can be noted. Now I always carry several bags in my purse. During the New Year holidays, she allowed herself forbidden foods, and the result was not long in coming - an allergy began. I drank a bag of the drug Hepa-Merz and the rash began to pass.

Lyudmila

 About a year ago, pain began in the right hypochondrium and problems with the digestive system. I went to the hospital, was assigned to undergo an examination. Blood for biochemistry showed a high level of hepatic enzymes and bilirubin, ultrasound revealed diffuse changes in the liver. The doctor prescribed the drug Hepa-Merz 1 sachet 3 times a day for 10 days.
 A week later, pain in the right hypochondrium passed, the stomach stopped bothering. A month later, retook the tests, they were normal. A good hepatoprotector that helps quickly. The finished drink has a pleasant orange flavor.

Galina

Terms of sell

You can buy Hepa-Merz Hepa-Merz without a prescription.