Guttalax drops 7.5mg/ml 30ml

Instruction for Guttalax drops

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Composition

100 ml of the drug contains:
Active substances:
    sodium picosulfate monohydrate 0.75 g
Excipients:
    sodium benzoate 0.20 g;
    sodium citrate dihydrate 0.15 g;
    liquid sorbitol (non-crystallizing) 64.37 g;
    citric acid monohydrate 0.14 g;
    purified water 49.89 g.

Description

Transparent, colorless to yellowish or slightly tan, slightly viscous solution.
Pharmacotherapeutic group:
laxative.

Pharmacodynamics

The active substance - sodium picosulfate is a laxative of the triarylmethane group. As a local laxative, sodium picosulfate, after bacterial cleavage in the large intestine, has a stimulating effect on the mucosa of the large intestine, increasing peristalsis, and promotes the accumulation of water and electrolytes in the large intestine. This leads to stimulation of the bowel movement, a decrease in evacuation time and softening of the stool.
Sodium picosulfate, being a laxative acting at the level of the colon, stimulates the natural process of evacuation of contents from the lower parts of the gastrointestinal tract. Therefore, sodium picosulfate does not affect the digestion or absorption of high-calorie foods or essential nutrients in the small intestine.

Pharmacokinetics

Absorption: insignificant, the drug is almost completely metabolized in the intestinal wall and liver to inactive glucuronide.
After oral administration of sodium, picosulfate enters the large intestine; the absorption of the drug is negligible, which excludes its enterohepatic circulation. In the distal colon, sodium picosulfate is cleaved to form an active metabolite, bis- (p-hydroxyphenyl) -pyridyl-2-methane. The time of development of the laxative effect of the drug is determined by the release rate of the active metabolite and is 6-12 hours after use (on average 10 hours).
An insignificant part of Guttalax drops enters the systemic circulation. There is no correlation between the laxative effect of the active metabolite and its concentration in the blood serum.
After taking 10 mg of the drug inside, about 10.4% of the total dose is excreted by the kidneys in the form of glucuronide after 48 hours.
When using higher doses of Guttalax drops, its excretion by the kidneys, in general, decreases.

Indications for use

As a laxative in the following cases:
    constipation due to atony and hypotension of the colon (including in old age, in bedridden patients, after operations, after childbirth and during lactation)
    constipation caused by medication
    to regulate the stool with hemorrhoids, proctitis, anal fissures (to soften the stool consistency)
    gallbladder disease, irritable bowel syndrome with a predominance of constipation
    constipation due to intestinal dysbiosis, dietary disorders.

Contraindications

    Intestinal obstruction or obstructive bowel disease;
    acute diseases of the abdominal organs or severe abdominal pain, which may be accompanied by nausea, vomiting, fever, including appendicitis;
    acute inflammatory bowel disease;
    hypersensitivity to sodium picosulfate or other components of the drug;
    severe dehydration;
    fructose intolerance.

Carefully

In the II and III trimesters of pregnancy (as with other laxatives), the drug is possible only as directed by a doctor.
The active metabolite and its glucuronides are not excreted in breast milk. Thus, the drug can be used during breastfeeding.

Pregnancy and lactation

There are no data on reliable and well-controlled studies in pregnant women. Long-term experience of use did not reveal a negative effect of the drug on pregnancy. Taking the drug in the first trimester of pregnancy is contraindicated. Studies on the effect of the drug on fertility have not been conducted. In preclinical studies, teratogenic effects on reproduction were not detected.

Dosage and administration

Inside.
Adults and children over 10 years:
10-20 drops (5-10 mg) per day
Children 4-10 years old:
5-10 drops (2.5-5 mg) per day
It is recommended to start Guttalax drops with the lowest dose. In order to achieve regular stool, the dose may be increased to the maximum recommended. Do not exceed the maximum recommended daily dose.
The recommended dose for children under 4 years old is 0.25 mg / kg body weight per day. This corresponds to 1 drop of the drug (0.5 mg sodium picosulfate) per 2 kg of body weight per day.
To obtain a laxative effect in the morning, you should take the drug the night before. The drug does not have to be dissolved in a liquid.

Side effect of Guttalax drops

From the gastrointestinal tract discomfort, nausea, vomiting, cramping and pain in the abdomen, diarrhea are possible.
From the nervous system, dizziness and fainting are possible. Dizziness and fainting after taking the drug may be associated with a vasovagal reaction (for example, tension during bowel movements, cramping in the abdomen).
Hypersensitivity reactions are possible from the side of the immune system. From the side of the skin and subcutaneous tissues, skin reactions are possible, for example, angioedema, skin rash, itching.

Overdose

Symptoms

When taking high doses are possible: diarrhea, dehydration, lowering blood pressure, disturbance of water-electrolyte balance, hypokalemia, convulsions. In addition, there are reports of cases of large intestine ischemia associated with taking drops Guttalax doses that are significantly higher than those recommended for the usual treatment of constipation.
Guttalax drops, like other laxatives, with chronic overdose can lead to chronic diarrhea, pain in the abdomen, hypokalemia, secondary hyperaldosteronism, urolithiasis. In connection with chronic abuse of laxatives, damage to the renal tubules, metabolic alkalosis, and muscle weakness associated with hypokalemia can develop.

Treatment

To reduce the absorption of the drug after oral administration, you can induce vomiting or gastric lavage. It may be necessary to replenish the fluid and correct the balance of electrolytes, as well as the appointment of antispasmodics.

Interaction with other drugs

Diuretics or glucocorticosteroids increase the risk of electrolyte imbalance (hypokalemia) when taking high doses of Guttalax drops.
An electrolyte imbalance can increase sensitivity to cardiac glycosides.
The combined use of the drug and antibiotics can reduce the laxative effect of the drug.

Special instructions

Do not use the drug daily without consulting a doctor for more than 10 days. Long-term use of high doses of the drug can lead to fluid loss, imbalance in electrolytes, hypokalemia.
Dizziness and fainting were observed in patients taking Guttalax drops. Analysis showed that these cases are associated with fainting during bowel movements (or fainting caused by tension during bowel movements), or with a vasovagal reaction to abdominal pain, which may be due to constipation, and is not necessarily associated with taking the drug.
1 ml of drops contains 0.45 g of sorbitol. The maximum recommended daily dose for the treatment of adults and children 4-10 years old contains 0.6 g and 0.3 g of sorbitol, respectively.
The drug does not have taste, so children can be added to food. Children should take the drug only as directed by a doctor.

Terms of sell

You don't need a prescription to buy Guttalax drops.