Panatus Forte tabs 50mg #10

Panatus Forte instruction for use

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Panatus forte is a central action antitussive.

Release form and composition

    film-coated tablets: round, biconvex, with a bevel, red-brown color; a rough white mass covered with a red-brown shell is visible at the kink (10 pieces in blisters, 1 blister in a cardboard bundle).
Each pack also contains instructions for the use of Panatus forte.
Composition of 1 film-coated tablet:
    active substance: butamirate citrate - 50 mg;
    auxiliary components: colloidal silicon dioxide, hypromellose K15M Premium, povidone K-25, magnesium stearate, talc, lactose monohydrate;
    film coat: propylene glycol, hypromellose 6 mPas, talc, titanium dioxide (E171), iron dye oxide red (E172).

Pharmacodynamics

The active ingredient of Panatus forte is butamirate - a centrally acting antitussive that is not related to opium alkaloids, either in chemical or pharmacological characteristics.
It has a direct effect on the cough center, due to which it suppresses cough. It has bronchodilating activity. Improves spirometry (reduces airway resistance) and blood oxygenation, making breathing easier.

Pharmacokinetics

Once in the gastrointestinal tract, butamirate is rapidly and completely absorbed.
With repeated use, the plasma concentration of the drug remains linear, cumulation in the body is not observed.
Butamirate undergoes hydrolysis in the blood, initially to metabolites of 2-phenylbutyric acid and diethylaminoethoxyethanol, which also have antitussive activity.
The substance itself and its metabolites are almost completely (approximately 95%) bound to plasma proteins. This explains their long-term therapeutic effect and long T½ (half-life).
Metabolites are excreted mainly by the kidneys, and metabolites with an acid reaction are significantly associated with glucuronic acid. T½ is 6 hours.

Indications for use

    treatment of dry cough of any etiology, including pertussis;
    cough suppression during surgical interventions, bronchoscopy, in the preoperative and postoperative periods.

Contraindications

Absolute:
    fructose intolerance - for syrup;
    lack of lactase, lactose intolerance and glucose-galactose malabsorption syndrome - for tablets;
    children's age up to 3 years - for syrup, up to 12 years - for tablets;
    I trimester of pregnancy and lactation;
    hypersensitivity to any component of the drug.
Panatus forte is used with caution in the II and III trimesters of pregnancy.

Instructions for use: method and dosage

The drug should be taken orally, before meals.
Depending on the age, Panatus forte tablets are prescribed in the following doses:
    12-18 years - 1 pc. 1-2 times a day;
    over 18 years - 1 pc. 2-3 times a day.
The duration of treatment is up to 7 days. If the cough persists, consult your doctor.

Side effects

Panatus forte is predominantly well tolerated.
In rare cases (from ≥ 1/10 000 to <1/1000), the following adverse reactions occur:
    on the part of the skin: exanthema;
    from the central nervous system: drowsiness, dizziness;
    from the gastrointestinal tract: nausea, diarrhea, vomiting;
    others: allergic reactions.

Overdose

In case of an overdose, butamirate causes the following reactions: abdominal pain, nausea, diarrhea, vomiting, decreased blood pressure, dizziness, impaired coordination of movements, irritability, drowsiness.
If you take an excessive dose of the drug, you should rinse your stomach, take an adsorbent (for example, activated charcoal) and a laxative. Further treatment is symptomatic, including maintaining the functions of the respiratory and cardiovascular systems. The antidote is unknown.

special instructions

Panatus forte syrup can be prescribed for diabetes, since it contains sodium saccharin and sorbitol as sweeteners. The content of sorbitol in a single dose depending on its volume: in 1 scoop (5 ml) - 1.75 g, in 2 scoops (10 ml) - 3.5 g, in 3 scoops (15 ml) - 5, 25 g
The composition of 1 tablet Panatus forte included 0.285 g of lactose.

Influence on the ability to drive vehicles and complex mechanisms

The drug can cause drowsiness and dizziness, which should be considered for drivers of vehicles and persons performing potentially dangerous types of work that require speed of reaction and increased attention.

Pregnancy and lactation

Whether butamirate crosses the placental barrier is not known. There is no information on the safety of the drug during pregnancy. In this regard, in the first trimester, it is not recommended to take Panatus forte; in the second and third trimesters, use is possible only as prescribed by the attending physician.
There are no data on the excretion of butamirate with breast milk, therefore, the drug is not recommended for breastfeeding women.

Use in childhood

Age restrictions:
    syrup - up to 3 years;
    tablets - up to 12 years.

Drug interaction

Panatus forte is not recommended for use simultaneously with ethanol and drugs that have a depressing effect on the central nervous system, including sleeping pills, antipsychotics, and tranquilizers.
It is not necessary to take expectorant drugs during the treatment period, otherwise accumulation of sputum in the respiratory tract is possible.
Other drug interactions with butamirate are not described.

Terms and conditions of storage

Store in the original packaging at a temperature not exceeding 25 ° C in a place inaccessible to children.
The shelf life of the syrup is 4 years, tablets - 5 years.

Reviews

Patients leave mostly positive reviews about Panatus Forte, noting its high effectiveness when used according to indications, good tolerance and relatively low cost.
In rare reports of a negative nature, there are complaints of the lack of effect after a course of treatment.

Terms of sell

A prescription is not required to buy Panatus Forte.