Panatus Forte syrup 7.5mg/5ml 200ml

Panatus Forte syrup user manual

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Release form, composition and packaging

Syrup in the form of a clear liquid, colorless to light yellow in color, with a characteristic odor.
5 ml (1 scoop):
butamirate citrate - 7.5 mg
Excipients: citric acid monohydrate, liquid sorbitol, glycerol, sodium saccharin, sodium benzoate, lemon flavor, sodium hydroxide, purified water.

pharmachologic effect

Panatus Forte syrup is antitussive agent of central action. Butamirate does not apply to opium alkaloids. Suppresses cough, having a direct effect on the cough center. It has an expectorant, moderate bronchodilating and anti-inflammatory effect. Improves spirometry (reduces airway resistance) and blood oxygenation.

Pharmacokinetics

Quickly and completely absorbed by ingestion. With repeated use, its concentration in the blood plasma remains linear and cumulation is not observed. In the blood it undergoes hydrolysis with the formation of 2-phenylbutyric acid and diethylaminoethoxyethanol. These metabolites also have antitussive activity. The binding of butamirate and its metabolites to plasma proteins is about 95%, this is due to their long T1 / 2 and long antitussive effect. Metabolites are excreted mainly by the kidneys, and metabolites with an acid reaction are largely associated with glucuronic acid. T1 / 2 - 6 hours

Indications

Dry cough of any etiology (for colds, flu, whooping cough and other conditions).
Cough in the preoperative and postoperative period, during surgical interventions, bronchoscopy.

Dosage regimen

For oral administration.
The dose is set individually, depending on the dosage form used and the age of the patient.

Side effect of Panatus Forte syrup

From the side of the central nervous system: rarely (≥1 / 10,000 to <1/1000) - drowsiness, dizziness.
From the digestive system: rarely (≥1 / 10,000 to <1/1000) - nausea, vomiting, diarrhea.
From the skin: rarely (≥1 / 10,000 to <1/1000) - exanthema.
Other: allergic reactions may develop.

Contraindications for Panatus Forte syrup

I trimester of pregnancy, lactation (breastfeeding); children's age up to 2 months; children under 3 years old (for syrup), children under 6 years old (for tablets); children under 18 years of age (for modified release tablets); hypersensitivity to butyrate.

Carefully

II and III trimesters of pregnancy.

Pregnancy and lactation

Use Panatus Forte syrup in the first trimester of pregnancy and during lactation (breastfeeding) is contraindicated. In the II and III trimesters of pregnancy, they are used with caution and only in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus.

Use in children

Contraindication: children up to 2 months (for drops), up to 3 years (for syrup), up to 12 years (for depot tablets).

special instructions

In children, Panatus Forte syrup should be used only in dosage forms that are specifically designed for this category of patients in accordance with age.

Impact on the ability to drive vehicles and mechanisms

Butamirate is capable of causing drowsiness, therefore, during the treatment period, patients should be careful when driving vehicles and other activities that require an increased concentration of attention and speed of psychomotor reactions.

Drug interaction

Due to the fact that butamirate suppresses the cough reflex, the simultaneous use of expectorants should be avoided to avoid the accumulation of sputum in the respiratory tract.
During treatment with Panatus Forte syrup, the use of drugs that have a depressing effect on the central nervous system (including sleeping pills, antipsychotics, tranquilizers) is not recommended.

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