Libexin Muco syrup 2% 125ml

Instruction for Libexin Muco

You can buy Libexin Muco here

Libexin Muco is an expectorant and mucolytic drug.

Release form and composition

Libexin Muco is available in the following dosage forms:
syrup for children: red liquid with a consistency characteristic for syrups (125 ml or 200 ml in colorless glass bottles, closed with a threaded aluminum lid with first opening control; one bottle in a cardboard bundle, measuring spoon and instructions for use of Libexin Muco).
Composition per 100 ml of syrup for children:
    active component: carbocysteine ​​- 2 g;
    auxiliary components: methyl parahydroxybenzoate, sodium hydroxide (up to pH 6.1–6.3), sucrose, cherry flavor, raspberry flavor, crimson dye (Ponceau 4R), purified water.
One scoop (5 ml) of syrup contains 3.5 g of sucrose, 100 mg of carbocysteine ​​and 13 mg of sodium.

Pharmacodynamics

The active substance of the syrup Libexin Muco - carbocysteine, is a mucolytic, thin the sputum and facilitate its excretion from the lungs. The mechanism of its action is based on the effect on the gel phase of bronchial secretion and rupture of disulfide bridges of glycoproteins, as a result of which the viscosity of the secretion decreases and its elasticity increases.
Carbocysteine ​​activates the goblet cell enzyme (sialic transferase) of the bronchial mucosa, normalizes the ratio of neutral and acid sialomucins, restores the structure and promotes the regeneration of the mucous membrane, resumes the secretion of immunoglobulin A (specific protection), activates the work of the ciliary epithelium, improves non-specific local protection of the respiratory mucosa from external influences.

Pharmacokinetics

After oral administration, carbocysteine ​​is actively absorbed in the gastrointestinal tract. The maximum serum concentration is reached after about 2 hours. Due to the effect of the first passage through the liver, carbocysteine ​​has a very low bioavailability (less than 10%).
The half-life of the drug is approximately 2 hours. Excretion is carried out mainly by the kidneys.

Indications for use

Libexin Muco is used for chronic and acute diseases of the ENT organs, bronchi and lungs, accompanied by the formation of mucus and difficult to separate, viscous sputum, namely: bronchitis, tracheitis, rhinitis, sinusitis, tracheobronchitis, otitis media, bronchiectatic disease, bronchial asthma.
In addition, the drug is prescribed to patients during preparation for bronchography or bronchoscopy.

Contraindications

Absolute:
    cystitis;
    exacerbation of chronic glomerulonephritis;
    exacerbation of peptic ulcer of the duodenum and stomach;
    children's age up to 2 years (for the drug in the form of a syrup for children);
    children and adolescents under 15 years of age (for the drug in the form of a syrup);
    pregnancy period;
    hypersensitivity to the main or auxiliary components of the drug.
Relative (Libexin Muco is used with caution):
    indications of a history of peptic ulcer of the duodenum and stomach;
    lactation period;
    elderly age;
    concomitant use with drugs that increase the risk of gastrointestinal bleeding.

Instructions for use (dosage and method)

Libexin Muco should be taken orally, preferably not with meals.
Adults and adolescents over 15 years of age, the drug is prescribed 15 ml (1 measuring cup) three times a day. The course of treatment is no more than 8 days.
In children and adolescents aged 2 to 15 years, Libexin Muco syrup for children should be used. Recommended Dosage:
    children aged 2–5 years - 5 ml (1 scoop) twice a day;
    children over 5 years old - 5 ml (1 measured spoon) three times a day.
The duration of therapy without consulting a doctor is no more than 8 days.

Side effects

    digestive system: epigastric pain, nausea, vomiting, loose stools, bleeding from the gastrointestinal tract;
    immune system: skin rash, urticaria, pruritus, fixed drug rash, Quincke edema, exanthema;
    skin and subcutaneous fat: in some cases - bullous dermatitis (erythema multiforme, Stevens-Johnson syndrome);
    other reactions: weakness, dizziness, malaise.

Overdose

With an overdose of Libexin Muco, the patient feels nauseous, pain in the stomach, diarrhea may occur.
Symptomatic therapy is performed.

special instructions

In case of development of bleeding from the gastrointestinal tract, Libexin Muco should be discontinued.
The ethanol content in the syrup is 1.64%, that is, in one measuring cup contains 0.2 g of ethanol. This should be considered when prescribing a drug to patients with liver diseases, epilepsy, diseases or brain injuries, as well as to persons with alcohol dependence.
Information for patients with diabetes and people following a low-carb diet: 15 ml of syrup (1 measuring cup) contains 6 g of sucrose, 5 ml of syrup for children (1 measuring spoon) contains 3.5 g of sucrose.
It should also be noted that in 15 ml of syrup, the sodium content is 97 mg, and in 5 ml of Libexin Muco syrup for children - 13 mg. This information is required for patients who follow a low-salt or salt-free diet.
Since sucrose is one of the auxiliary components of Libexin Muco, syrup is not recommended for patients with fructose intolerance, isomaltase / sucrose deficiency, and glucose-galactose malabsorption syndrome.

Influence on the ability to drive vehicles and complex mechanisms

Libexin Muco can cause dizziness and weakness, therefore, during treatment with the drug, care must be taken when driving and while working with other potentially dangerous mechanisms.

Pregnancy and lactation

Data on the use of syrup in pregnant women are limited, so the drug is not recommended for use during pregnancy.
During breastfeeding, Libexin Muco is used with caution, since it is not known whether carbocysteine ​​passes into breast milk.

Use in childhood

Syrup for children can be used starting from 2 years of age.

Drug interaction

With simultaneous use with antibacterial agents and glucocorticosteroids intended for the treatment of infectious and inflammatory diseases of the respiratory tract, carbocysteine ​​increases the effectiveness of these funds.
Libexin Muco potentiates the bronchodilator effect of theophylline.
Atropine-like and antitussive drugs weaken the therapeutic activity of carbocysteine.
Since the syrup contains ethanol, it is used with caution simultaneously with the following agents (due to the risk of disulfiram-like reactions - flushing of the skin, redness, vomiting, tachycardia):
    cephalosporin antibiotics (cefamandol, latamoxef, cefoperazone);
    disulfiram;
    sulfonylurea derivatives and hypoglycemic drugs (glibenclamide, tolbutamide, chlorpropamide, glimepiride, glipizide);
    chloramphenicol;
    5-nitroimidazole derivatives (ornidazole, tinidazole, metronidazole, secnidazole);
    antifungal drugs (ketoconazole, griseofulvin);
    cytostatic agents (procarbazine);
    drugs that inhibit the central nervous system.

Terms and conditions of storage

Keep out of the reach of children, at a temperature not exceeding 25 ° C.
Shelf life is 3 years.

Reviews

The drug is used in both children and adults, but reviews about Libexin Muco in the form of syrup for children are slightly more. The drug copes very well with dry cough, contributing to a better discharge of sputum, and helps with diseases of the upper respiratory tract. The syrup has a pleasant taste and smell; children are happy to drink it.
Sometimes Libexin Muco was not effective enough. Users note the high sugar content in the syrup, as well as the presence of dyes and flavorings in its composition. The drug may cause allergies. Another disadvantage is its cost.

Terms of sell

You don't need a prescription to buy Libexin Muco.