Timolol drops 0.5% 5ml

User manual for Timolol

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Dosage form, composition of Timolol

Timolol eye drops are a colorless, odorless solution. Packaged in 5 ml high density polyethylene tubes. The medicinal solution is produced with an active ingredient concentration of 0.25 or 0.5%. Each vial is equipped with a built-in dropper for accurate dosing of the medicine. The branded cardboard box contains one tube with drops, an insert sheet with a detailed description of the medication (indications, contraindications, method of application, dosage, etc.).
The active ingredient in Timolol eye drops is a beta-blocker - timolol maleate. Auxiliary components:
    Natrii hydrophosphas (sodium dihydrogen phosphate);
    Edetate disodium (ethylenediaminetetraacetic acid disodium salt);
    Disodium phosphate dihydrate (disodium phosphate dihydrate);
    Рurificati aqua (purified water);
    Benzalkonii chloridum (benzalkonium chloride);
    Sodiumchloride (sodium chloride);
    Nátrii hydroxídum (sodium hydroxide).
Timolol drops are produced by several pharmaceutical companies from Russia, the Republic of Belarus, Germany, Romania, Israel. In the Russian Federation, the main manufacturers are the Moscow Endocrine Plant (MEZ) and Solopharm (Solopharm).

Therapeutic action

Drops Timolol - antiglaucoma agent, non-selective beta-blocker. The action is aimed at reducing intraocular pressure. The exact mechanism for lowering IOP is not known. Perhaps this property is achieved by reducing the formation of aqueous humor and its partial withdrawal from the organ of vision. Unlike other similar medicines, Timolol does not impair vision (day, night), does not dilate the pupil. After instillation, the therapeutic effect is observed after 20-30 minutes and lasts 12 hours.
The components of the drug are able to quickly overcome the cornea. The solution enters the systemic circulation through the conjunctiva, nose, oropharynx, lacrimal tract. The maximum concentration in the blood is recorded 2 hours after instillation. The plasma detection threshold is maintained for 12 hours. It is excreted from the body in an altered form by the kidneys along with urine.

Indications for appointment

Timolol drops are indicated for use in the following cases:
    open-angle glaucoma - a persistent increase in intraocular pressure with a tendency to progress;
    angle-closure glaucoma - a pathology resulting from an increase in IOP due to the closure of the anterior chamber angle;
    secondary glaucoma - complications and consequences of various conditions or injuries of the organ of vision, which are accompanied by an increase in intraocular pressure;
    a sharp increase in IOP.
Another indication indicated in the instructions is the ineffectiveness of the use of therapeutic measures for congenital glaucoma.

Contraindications

According to the instructions, Timolol cannot be used in the presence of certain diseases and conditions. Direct contraindications:
    sensitivity to at least one component of the medication;
    inflammation of the nasal mucosa - a runny nose;
    eye diseases accompanied by clouding (dystrophy) of the cornea;
    atrioventricular block (2, 3 degrees) without an artificial pacemaker;
    decreased heart rate - sinus bradycardia;
    severe obstructive chronic pulmonary disease;
    chronic heart failure;
    severe left ventricular failure - cardiogenic shock;
    chronic inflammation of the airways.
Relative contraindications:
    impaired renal and liver function;
    lung disease;
    thinning of the mucous membranes of the nose;
    diabetes;
    myasthenia gravis;
    pregnancy;
    lactation;
    childhood (especially the period of infancy).
Such patients should be prescribed the drug by the attending physician and only after a thorough study of the alleged benefits and harms of Timolol.

Side effects

The instructions for use indicate a fairly wide list of side effects. Lachrymation, photophobia, as well as burning and itching in the eyes are reactions from the organ of vision. Other unwanted consequences:
    vomiting, nausea;
    migraine-type headache;
    shortness of breath, bronchospasm;
    indigestion;
    heart palpitations;
    chest pain;
    arterial hypotension;
    runny nose, nosebleeds;
    tiredness, drowsiness;
    dizziness;
    depression;
    sleep disturbance;
    ringing in the ears, hearing impairment;
    muscle weakness;
    rashes on the skin;
    decreased potency.
In children (especially in infants), the concentration of the active ingredient in the plasma is greater than in adults. Therefore, their side effects may be more pronounced.

Method of application, dosage

Timolol eye drops are prescribed for medicinal purposes. The medicinal solution is used topically by instillation into the conjunctivitis sac. The therapy is started using drops with an active substance concentration of 0.25%. The standard dosage for newborns and adults is a drop in each conjunctivitis sac 1-2 times a day. If no positive dynamics is observed against the background of treatment, a concentrated solution of 0.5% is prescribed. Drop by drop 1-2 times a day - for children over 10 years old and adults.
As the condition improves, when IOP normalizes, the frequency of instillations is reduced to once a day. It is preferable to carry out the procedure in the morning. As a rule, the course of therapy is long and can take several months. The duration of treatment depends on the clinical efficacy of Timolol drops.

Overdose

Overdose is unlikely if the recommended dosage regimen is strictly followed. Overdose cases were recorded with an accidental increase in the dose of the drug. In this case, there is an increase in side effects and the addition of life-threatening signs:
    a sharp decrease in blood pressure;
    rapid pulse;
    cardiogenic shock;
    loss of consciousness;
    convulsions;
    collapse;
    heart failure.
If you accidentally swallow the medicine, you need to induce vomiting, drink any sorbent, and then call an ambulance. In most cases, hospitalization of the patient is required, followed by treatment in a hospital setting.

Special recommendations

Before therapy, you must read the special recommendations for drops:
    During the period of treatment, you need to regularly visit an ophthalmologist in order to control the pressure.
    The preservative in the drops can damage contact lenses. Therefore, it is recommended to replace the ophthalmic device with glasses during therapy.
    Contact lenses of a rigid structure are removed before instillation, they can be put on 15-20 minutes after the procedure.
    It is prescribed with caution together with glucocorticosteroids, cytostatics, tranquilizers, with antihypertensive drugs.
    It is necessary to abandon the use of drops before any surgical intervention using general anesthesia for two days.
    It is strictly forbidden to simultaneously use drops with local ophthalmic agents from the group of beta-blockers.
    During the period of treatment, you should avoid driving and work requiring attention and accuracy. If this is not possible, then you can get behind the wheel of a car 30-40 minutes after instillation.
With prolonged treatment, the effectiveness of Timolol drops may decrease.

Interaction with other medications

With the simultaneous use of Timolol with some drugs, undesirable consequences may occur. It is not recommended to combine drops with the following groups of medicines:
    local anesthetics;
    systemic beta-adrenergic receptor blockers;
    cardiac glycosides;
    calcium antagonists.
During treatment with the drug, it is forbidden to consume alcoholic beverages in order to avoid a sharp decrease in blood pressure.

Additional Information

The shelf life of a closed bottle is 2 years from the date of manufacture. After opening, the medicinal solution is suitable for use within 30 days. Drops are stored in original packaging and in a place where direct sunlight does not fall. Storage temperature - no higher than 25 ° С. The access of children and pets to the medicine is necessarily limited.

Consumer reviews

Lydia Petrovna, 46 years old
I have type 2 diabetes. The pathology is very dangerous, as the vessels on the lower extremities, vision, kidneys suffer. I visit the ophthalmologist 2 times a year. At the last visit, it turned out that the intraocular pressure was increased. To avoid the development of glaucoma, 1 drop was prescribed once a day for 40 days. There were no side effects against the background of the use of drops. After the course of therapy, a control blood pressure measurement was performed. Indicators are within normal limits. I am very glad that the drug helped me.
Katya, 33 years old
Timolol 0.5% eye drops are intended for the treatment of glaucoma, but I bought them for other purposes! The drug was recommended by a pediatrician to eliminate hemangioma on the face of a child. In our case, expensive ointments and pills were ineffective. I rubbed the sore spot with drops 3 times a day, trying to maintain an interval of 6 hours. The spot has noticeably turned pale after 2 weeks, we continue the treatment. Hope it disappears completely.

Terms of sell

A prescription is not required to buy Timolol.