Tinidazole tabs 500mg #4

Tinidazole instruction

You can buy Tinidazole on this page

This drug is widely used in the field of modern medicine to combat giardiasis, trichoionosis in acute or chronic form, infectious lesions provoked by anaerobic bacteria, as well as infectious diseases that accompany the development of ulcerative lesions of the gastrointestinal tract.
The mechanism of action of tinidazole is due to its ability to inhibit the synthesis and damage the structure of bacterial DNA.

Composition and release form

Tinidazole is available in the form of tablets having a white or almost white color. The tablets have a round biconvex shape and contain 500 mg of the active ingredient (tinidazole).
Corn starch, lactose, methylhydroxybenzoate, magnesium stearate, purified talc, anhydrous colloidal silicon act as auxiliary components of the drug.
To the drug Tinidazole instruction is enclosed in each carton, with 1 or 4 tablets.

pharmachologic effect

Tinidazole is used as an effective antiprotozoal agent with high antibacterial efficacy. The mechanism of its action is due to the qualitative inhibition of synthesis, as well as damage to the DNA structure of the pathogen. The drug is effective against a number of anaerobic bacteria, as well as Lamblia intestinalis, Trichomonas vaginalis, Entamoeba histolytica.
Bioavailability of Tinidazole is approximately 100%, since its degree of absorption is very high. The maximum concentration of the drug in the blood is reached 2 hours after administration and is 40 - 51 µg / ml with 2 g of the drug, and after 24 hours it drops to 11 - 19 µg / ml. Up to 1 µg / ml concentration decreases after 72 hours after administration.
Tinidazole has the ability to penetrate the BBB and through the placental barrier and is excreted in breast milk for 72 hours after ingestion. Drug metabolism occurs in the liver, and pharmacologically active derivatives are formed that are able to inhibit the growth of anaerobic bacteria and enhance its effect. Approximately 50% of the drug is excreted in the bile, about 25% is excreted by the kidneys unchanged, and another 12% in the form of metabolites.

Indications for use

Tinidazole is indicated for use in patients with the following types of infections:
    Giardiasis.
    Amebiasis (including liver).
    Trichomoniasis.
    Various combinations of anaerobic bacteria.
    Mixed anaerobic-aerobic infections (requires additional prescription of antibiotics).
    Detection in the human body of gastric ulcer caused by Helicobacter pylori (with antibiotics and bismuth preparations).
Tablets are prescribed for prophylactic purposes in the postoperative period to stop the development of anaerobic bacteria.

Contraindications

    people who are hypersensitive to tinidazole;
    for violations of blood;
    diseases of the nervous system during the period of exacerbation;
    women in the first months of pregnancy and breastfeeding.
The drug is not taken simultaneously with alcohol. If a person suffers from nausea or vomiting, then treatment with Tinidazole should be postponed. And also it is not prescribed simultaneously with ethionide.

Appointment during pregnancy and lactation

The use of Tinidazole in the first trimester of pregnancy is absolutely contraindicated. The use of Tinidazole on other terms is possible only in case of urgent need.
Breastfeeding should be discontinued during the treatment with Tinidazole.

Dosage and method of use

As indicated in the instructions for use of the tablet Tinidazole should be taken orally, in order to avoid the development of side effects from the digestive system - during or after a meal.
Recommended dosing regimens:
    Giardiasis, trichomoniasis: adults - 2000 mg once, children - 50–75 mg / kg once. If necessary, the drug is taken again in the same dose;
    infections in adults caused by anaerobes: the initial dose is 2000 mg once, from day 2 it is 1000 mg per day. The course of therapy is 5-6 days;
    intestinal amebiasis: adults - 2000 mg per day for 2-3 days, children - 50-60 mg / kg for 3 days;
    hepatic amebiasis: adults, 1500–2000 mg per day for 3–6 days, children, 50–60 mg / kg for 5 days.
To prevent the development of postoperative complications in adults, the drug is prescribed 12 hours before the upcoming surgery at a dose of 2000 mg.

Side effects

From the use of Tinidazole, the most common side effects are:
    allergic reactions: rash, pruritus, urticaria, angioedema;
    on the part of the central nervous system: ataxia, dizziness, headache, peripheral neuropathy; rarely seizures;
    from the gastrointestinal tract: an unpleasant taste and dry mouth, diarrhea, nausea, anorexia, vomiting;
    others: rarely - weakness, transient leukopenia.

Overdose

No overdose of Tinidazole was observed. A specific antidote to this drug has not been developed, therefore, standard recommendations should there be signs of overdose: give the patient plenty of drink, induce vomiting, flush his stomach, give him dialysis.

special instructions

Before you start using the drug, read the specific instructions:
    In the process of treatment should refrain from alcohol.
    With the use of tinidazole, dark urine staining is observed.
    In the treatment of trichomoniasis should be the simultaneous treatment of both partners.
    If adverse reactions from the CNS occur, tinidazole should be withdrawn.
    If treatment continues for more than 6 days, regular monitoring of the peripheral blood pattern should be carried out.
    For the prevention of postoperative anaerobic infections, doses for children under the age of 12 years have not been established.
During treatment, patients should refrain from practicing potentially hazardous activities that require increased attention and high-speed psychomotor reactions.

Interaction with other drugs

Tinidazole is not compatible with antibacterial drugs (cephalosporins, rifampicin, erythromycin, aminoglycosides), sulfonamides. Phenobarbital helps to speed up the metabolic process. Tinidazole is not prescribed with ethionamide.
The drug enhances the effect of indirect anticoagulants, reducing the dosage of the drug in half reduces the risk of bleeding.

Reviews

We offer you to read the reviews of people who used the drug Tinidazole:
Marina
    We drank with my husband - they prescribed it as a remedy for Giardia, the doctor prescribed a drink for the whole family, because found lamblia in a child. The course for 3 days with my husband. He is OK, no side effects, nothing, but I had terrible bitterness in my mouth for three days, but after the cancellation I immediately passed and the constipation was small, but after the cancellation, everything passed. In the right hypochondrium, a couple of times, well, so there is a gall, etc. So everyone has different side effects, but someone does not. Bitterness in the mouth and you can suffer, especially if the drug is valid.
Inna
    On a routine survey found Giardia. The doctor advised to buy Tinidazole. I was very surprised that you only need one application. I studied reviews on the Internet - most patients praised the drug. The price was quite reasonable - found for 20 rubles. After 2 weeks after the treatment she passed the repeated analysis - the giardia disappeared. Glad my doctor prescribed an inexpensive, effective drug.
Sasha
    Tinidazole was prescribed for severe urogenital infection with nystatin. the treatment was virtually inconclusive. But I think that this was not the fault of the drugs, but the fault of the doctor, who didn’t do normal tests, did not determine the sensitivity of the infectious agent to the drugs. Therefore, from a damn about appointed complex, and suddenly help.

Terms of sell

You can buy Tinidazole without a prescription.