Suprax Solutab tabs 400mg #7

Instruction for Suprax Solutab

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pharmachologic effect

Semisynthetic antibiotic from the group of cephalosporins III generation for oral administration. It has a bactericidal effect. The mechanism of action is associated with inhibition of the synthesis of the bacterial cell wall. Cefixime is resistant to a wide spectrum of β-lactamase produced by many gram-positive and gram-negative bacteria.
In clinical practice and in vitro, the efficacy of cefixime was confirmed in infections caused by Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, Proteus mirabilis, Neisseria gonorrhoeae.
Cefixime is also active in vitro against Gram-positive - Streptococcus agalactiae and Gram-negative bacteria - Haemophilus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, Providencia spp., Salmonelas are a good way to try, so when you’re looking for some other things, when your problems
Pseudomonas spp., Enterococcus spp., Listeria monocytogenes, most strains of Enterobacter spp., Staphylococcus spp. Are resistant to Suprax Solutab. (including methicillin-resistant strains), Bacteroides fragilis, Clostridium spp.

Pharmacokinetics

Suction

When ingestion bioavailability is 40-50% and does not depend on food intake. Cmax in adults' blood plasma after oral administration at a dose of 400 mg is reached in 3-4 hours and is 2.5-4.9 µg / ml, after administration at a dose of 200 mg - 1.49-3.25 µg / ml. Food intake on the absorption of the drug from the gastrointestinal tract has no significant effect.

Distribution

Vd with the introduction of 200 mg of cefixime was 6.7 liters, while reaching Css - 16.8 liters. About 65% of cefixime binds to plasma proteins. Cefixime creates the highest concentrations in urine and bile. Cefixime penetrates the placenta. The concentration of cefixime in the blood of the umbilical cord reached 1 / 6-1 / 2 of Suprax Solutab concentration in the maternal blood plasma; in breast milk, the drug is not determined.

Metabolism and excretion

T1 / 2 in adults and children is 3-4 hours. Cefixime is not metabolized in the liver; 50-55% of the accepted dose is excreted in the urine unchanged within 24 hours. About 10% of cefixime is excreted in the bile.

Pharmacokinetics in special clinical situations

In renal failure, an increase in T1 / 2 and, accordingly, a higher plasma concentration of Suprax Solutab and a slowing down of its elimination by the kidneys can be expected. In patients with CC 30 ml / min, when receiving 400 mg of cefixime T1 / 2 increases to 7-8 hours, plasma Cmax averages 7.53 μg / ml, and excretion in the urine in 24 hours - 5.5%. In patients with cirrhosis of the liver, T1 / 2 increases to 6.4 h, the time to achieve Cmax is 5.2 h; at the same time, the proportion of the drug eliminated by the kidneys increases. Cmax and AUC do not change.

Dosages of SUPRAX SOLUTAB

For adults and children weighing more than 50 kg, the daily dose is 400 mg in 1 or 2 doses.
Children with a body weight of 25-50 kg are prescribed in a dose of 200 mg / day in 1 dose.
The tablet can be swallowed with a sufficient amount of water, or diluted in water and drink the resulting suspension immediately after preparation. Suprax Solutab can be taken regardless of the meal.
The duration of treatment depends on the nature of the course of the disease and the type of infection. After the disappearance of symptoms of infection and / or fever, it is advisable to continue taking the drug for at least 48-72 hours.
The course of treatment for infections of the respiratory tract and ENT organs is 7-14 days.
For tonsillopharyngitis caused by Streptococcus pyogenes, the treatment should be at least 10 days.
With uncomplicated gonorrhea, Suprax Solutab is prescribed in a dose of 400 mg once.
With uncomplicated infections of the lower urinary tract in women, the drug is prescribed for 3-7 days, with uncomplicated infections of the upper urinary tract in women - within 14 days.
With uncomplicated infections of the upper and lower urinary tract in men, the duration of treatment is 7-14 days.
In case of impaired renal function, the dose is established depending on the CC in the serum. When CC 21-60 ml / min or in patients on hemodialysis, it is recommended to use other dosage forms of Suprax Solutab due to the need to reduce the daily dose by 25%. With QC of 20 ml / min or less or in patients on peritoneal dialysis, the daily dose should be reduced by 2 times.

Drug interactions

Tubular secretion blockers (including probenecid) slow down the excretion of cefixime in the urine, which can lead to overdose symptoms.
Cefixime reduces the prothrombin index, enhances the effect of indirect anticoagulants.
With simultaneous use of cefixime with carbamazepine, an increase in plasma concentration of the latter was observed; in such cases, it is advisable to conduct therapeutic drug monitoring.

Use of SUPRAX SOLUTAB during pregnancy

The use of the drug Suprax Solutab during pregnancy is possible in the case when the intended benefit to the mother outweighs the potential risk to the fetus.
If necessary, the use of Suprax Solutab during lactation breastfeeding should be temporarily discontinued.

SUPRAX SOLUTAB - side effects

Side effects are classified according to the frequency of reported cases: very often (> 10%); often (1-10%); infrequently (0.1-1%); rarely (0.01-0.1%); very rarely (≤ 0.01%).
On the part of the blood system: very rarely - transient leukopenia, agranulocytosis, pancytopenia, thrombocytopenia or eosinophilia; in some cases - a violation of blood coagulation.
Allergic reactions: rarely - urticaria, pruritus; very rarely - Lyell's syndrome (in this case, the drug should be immediately canceled), drug fever, serum sickness syndrome, hemolytic anemia and interstitial nephritis (epinephrine (adrenaline), systemic GCS and antihistamines are administered during the development of anaphylactic shock).
From the side of the central nervous system: infrequently - headaches, dizziness, dysphoria.
On the part of the digestive system: often - abdominal pain, digestive disorders, nausea, vomiting and diarrhea; rarely, transient increases in alkaline phosphatase and transaminase levels; very rarely - pseudomembranous colitis; in some cases - hepatitis and cholestatic jaundice.
From the urinary system: very rarely - a slight increase in the concentration of creatinine in the blood, hematuria.

Terms of storage of the drug SUPRAX SOLUTAB

The drug should be stored out of reach of children at a temperature not higher than 25 ° C. Shelf life - 3 years.

Indications for use SUPRAX SOLUTAB

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
- Streptococcal tonsillitis and pharyngitis;
- sinusitis;
- acute bronchitis;
- exacerbation of chronic bronchitis;
- acute otitis media;
- uncomplicated urinary tract infections;
- uncomplicated gonorrhea;
- shigellosis.

Special instructions for taking SUPRAX SOLUTAB

Due to the possibility of cross-allergic reactions with penicillins, it is recommended to carefully evaluate the history of patients. If an allergic reaction occurs, the use of the drug should be immediately discontinued.
With long-term use of the drug may disrupt the normal microflora of the intestine, which can lead to excessive reproduction of Clostridium difficile and the development of pseudomembranous colitis. With the appearance of mild forms of antibiotic-associated diarrhea, as a rule, it is enough to stop taking the drug. In more severe forms, corrective treatment is recommended (for example, oral administration of vancomycin 250 mg 4 times / day). Antidiarrheal drugs that inhibit the motility of the gastrointestinal tract, with the development of pseudomembranous colitis are contraindicated.
In the case of the use of the drug Suprax Solutab simultaneously with aminoglycosides, polymyxin B, sodium colysymetatum, "loop" diuretics (furosemide, ethacrynic acid) in high doses, it is necessary to monitor the kidney function especially carefully. After long-term treatment with Suprax Solutab, the state of hematopoiesis function should be checked.
Dispersible tablets should be dissolved only in water.
During treatment, a false-positive direct Coombs reaction and a false-positive reaction of urine to glucose are possible when using some test systems for rapid diagnosis.

Influence on ability to drive motor transport and control mechanisms

Studies on the effects of the drug Suprax Solutab on the ability to drive vehicles and mechanisms was not conducted. Due to possible adverse effects (eg, dizziness), caution should be exercised.

Terms of sell

You don't need a prescription from a doctor to buy Suprax Solutab.