Suprax caps 400mg #6

Instruction for Suprax

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Composition

One capsule contains:
active ingredient: cefixime trihydrate 466 mg (equivalent to cefixime 400 mg),
excipients: colloidal silicon dioxide (aerosil 200), magnesium stearate, carmellose calcium (carboxymethylcellulose calcium),
composition of capsule shell: azorubine (E 122), indigo carmine (E 132), titanium dioxide (E 171), gelatin

Description

Capsules with a purple cap and a white case, size "0", with the code H808 printed on the capsule.
The contents of the capsule are finely granulated powder from white to yellowish white with a characteristic odor.

Pharmacotherapeutic group

Other beta-lactam antibacterial drugs. Third generation cephalosporins. Cefixime.

Pharmacokinetics

When taken orally, the bioavailability of cefixime ranges from 40 to 50% regardless of food intake, however, the maximum concentration of cefixime in blood serum is achieved faster by 0.8 hours while taking Suprax with food. When taking 200 mg of the drug, the maximum concentration in serum is reached after 4 hours and is 3.5 μg / ml.
Communication with plasma proteins, mainly albumin, is 65%. The half-life of cefixime averages 3 to 4 hours, but it can reach 9 hours. In patients with moderate renal failure
(creatinine clearance from 20 to 40 ml / min) the half-life of Suprax is increased to 6.4 hours, and in patients with severe renal failure
(creatinine clearance from 5 to 20 ml / min) - up to 11.5 hours
About 50% of Suprax is excreted by the kidneys unchanged, about 10% with bile.

Pharmacodynamics

Suprax is a semisynthetic third-generation broad-spectrum cephalosporin antibiotic that acts bactericidally, inhibiting cell membrane synthesis, and is resistant to the action of beta-lactamase produced by most gram-positive and gram-negative bacteria.
Active against the following microorganisms:
Gram-positive: Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae;
Grammagnegtaggea; , Serratia marcescens;
Resistant to cefixime: Pseudomonas spp., Enterococcus (Streptococcus) serogroup D, Listeria monocitogenes, Staphylococcus spp., Including methicillin-resistant strains, Enterobacter spp., Bacteroides fragilis, Clostridium spp.

Indications for use

- pharyngitis, tonsillitis and sinusitis
- acute bronchitis and exacerbations of chronic bronchitis
- otitis media
- uncomplicated urinary tract infection
- uncomplicated urethral and cervical gonorrhea
- bacterial gastroenteritis

Dosage and administration

Adults:
The recommended dose of Suprax is 400 mg (one capsule) per day. For the treatment of uncomplicated urethral or cervical gonococcal infection, Suprax is recommended at a dose of 400 mg orally once.

Side effects of Suprax

- headache, dizziness, tinnitus, convulsions
- dry mouth, anorexia, nausea, vomiting, flatulence, constipation, diarrhea, abdominal pain, dysbiosis, candidiasis, stomatitis, glossitis
- skin hyperemia, skin rash, urticaria, exudative erythema multiforme (including Stephen-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), anaphylactic shock
- abnormal liver function, cholestasis, cholestatic jaundice, transient elevation of liver enzymes
- pancytopenia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia, bleeding
- interstitial nephritis, renal dysfunction, acute renal failure
- vaginitis, urogenital candidiasis
seldom
- pseudomembranous colitis, the development of hypovitaminosis B

Contraindications for Suprax

- individual intolerance to cephalosporin antibiotics
- nonspecific ulcerative colitis
- children's age up to 18 years
Drug interactions
During treatment with cephalosporin antibiotics, a false-positive result of the direct Coombs test was described; in this regard, it should be noted that a positive Coombs test may be due to the use of this drug.
As with other cephalosporins, some patients showed an increase in prothrombin time. In this regard, patients receiving therapy with anticoagulants, caution should be exercised.

special instructions

Prior to the initiation of therapy, it is necessary to conduct a thorough study of whether the patient in the past had hypersensitivity reactions to cephalosporins, penicillins, and other drugs.
With long-term use of Suprax may disrupt the normal microflora of the intestine, which can lead to excessive reproduction of Clostridium difficile and the development of pseudomembranous colitis. With the appearance of mild forms of antibiotic-associated diarrhea, as a rule, it is enough to stop taking the drug. In severe forms, corrective treatment is recommended (for example, the administration of vancomycin orally 250 mg 4 times a day).

Pregnancy and lactation

Use of Suprax during pregnancy is possible only when the intended benefit to the mother outweighs the potential risk to the fetus. If necessary, the use of the drug Suprax during lactation breastfeeding should be temporarily discontinued.
Features of the influence of Suprax on the ability to drive and potentially dangerous machinery
The drug does not affect the ability to drive a car and potentially dangerous machinery.

Overdose

Symptoms: increased side effects.
Treatment: there is no specific antidote, gastric lavage and symptomatic therapy are recommended.

Release form and packaging

6 capsules are placed in the blister packaging of their PVC / PVDH and aluminum foil.
On 1 planimetric packing together with the instruction for medical application in the state and Russian languages ​​place in a pack from a cardboard.

Storage conditions

Store at +15 ° C to +25 ° C.
Keep out of the reach of children!
Shelf life - 3 years
Do not use after expiration date.

Terms of sell

You don't need a prescription to buy Suprax.