Norfloxacin tabs 400mg #20

User manual for Norfloxacin

You can buy Norfloxacin here

By suppressing the DNA of microorganisms, destabilizes the chain, which leads to their death. It is taken orally for infections of the urinary system, the gastrointestinal tract, in both acute and chronic form, gonorrhea. Used as a preventive measure in patients with granulocytopenia.
This medicine will be applied topically in cases of inflammation in the ear, infectious eye diseases (blepharitis, conjunctivitis, keratitis, etc.).

Release form and composition

The drug is available in the form of film-coated tablets for oral administration. The tablets are packaged in blisters of 10 pieces (1-2 blisters in a carton box with the detailed description attached).
    Each tablet of the drug contains 400 mg of the active active ingredient - Norfloxacin.
    Auxiliary components - mannitol, titanium dioxide, macrogol, magnesium stearate.

Pharmacological effect

Norfloxacin is an antimicrobial drug belonging to the group of fluoroquinolones. It has a bactericidal effect, which is realized by inhibiting DNA gyrase, which ensures the stability and supercoiling of bacterial DNA. This causes the destabilization of the DNA chain and the death of bacteria.
The tablets of the drug are highly effective against the following pathogens:
    Escherichia;
    Gonococci;
    Hemophilus influenza;
    Klebsiella;
    Enterobacteria;
    Shigella;
    Chlamydia;
    Salmonella;
    Streptococci;
    Staphylococcus.
Norfloxacin does not show activity in relation to obligate anaerobes.

Indications for use

The use of the drug is indicated in the treatment of infectious diseases caused by pathogens sensitive to norfloxacin:
    uncomplicated gonorrhea;
    genital infections (endometritis, prostatitis, cervicitis);
    gastrointestinal tract infections (shigellosis, salmonellosis);
    acute and chronic urinary tract infections (cystitis, pyelonephritis, urethritis).
The drug is effective in preventing infectious diseases in patients with granulocytopenia.
Eye and ear drops for local use are used in the treatment of such diseases:
    dacryocystitis;
    acute inflammation of meibomian glands;
    external, acute and chronic otitis media; infectious diseases of the eye (keratitis, conjunctivitis, keratoconjunctivitis, blepharoconjunctivitis, blepharitis and corneal ulcer).
Norfloxacin is a preventive measure that reduces the risk of infectious complications before and after surgery, removal of foreign bodies from the cornea or conjunctiva, as well as after chemical damage to the eyes. For the same purpose, the drug is used in surgical interventions on the organs of hearing.

Contraindications

Absolute:
    Age up to 18 years;
    Period of pregnancy and lactation;
    Deficiency of glucose-6-phosphate dehydrogenase;
    Tendon and tendonitis rupture associated with taking fluoroquinolones (including historical data);
    Hypersensitivity to the drug.
Relative (Norfloxacin is prescribed with caution in the presence of the following diseases / conditions):
    Epilepsy;
    Convulsive syndrome;
    Hepatic / Renal Failure;
    Myasthenia gravis.

Use during pregnancy and lactation

This antibiotic is contraindicated to use during pregnancy and breast feeding. If there is an urgent need for treatment with this drug while breastfeeding, it is recommended to temporarily suspend it. When conducting experiments, it was recorded that the drug causes arthropathy in the fetus.

Dosage and method of use

The instructions for use indicate that a single dose of norfloxacin when administered orally is usually 1-2 tablets (400-800 mg) with a dose of 1-2 times a day. The maximum daily dose is 1.5 g.
With uncomplicated urinary tract infections, the course of administration is about 3 days, with complicated infections - about 7-10 days. In chronic processes, the course can be increased to 3 months.
The exact dose and duration of the course prescribed by the doctor individually for each patient.

Side effects

The drug is fairly well tolerated by the body, but can sometimes cause side effects. The body may experience the following reactions:
    Allergic reaction: swelling, itching, skin rash, urticaria.
    The digestive system: heartburn, bitter taste in the mouth, loss of appetite, diarrhea, nausea, abdominal pain, vomiting.
    Musculoskeletal system: tendon ruptures, tenditis, arthralgia.
    Cardiovascular system: decrease in blood pressure, tachycardia, vasculitis, arrhythmia.
    Central nervous system: insomnia, dizziness, fainting, headache, irritability, fatigue, anxiety.
    Urinary system: hypercreatininemia, glomerulonephritis, urethral bleeding, dysuria, albuminuria, crystalluria, interstitial nephritis, polyuria.
    When applied topically: photophobia, burning, pain, blurred vision, chemosis, conjunctival hyperemia.

Overdose

Symptoms of excessive dosing when taking the drug are severe drowsiness, dizziness, nausea with vomiting, the victim throws into cold sweat, his face becomes puffy.
The specific antidote is absent. As a curative measure, the following should be taken:
    urgently flush the stomach;
    apply forced diuresis in conjunction with the therapy of hydration nature.
The patient must be supervised by medical personnel.

special instructions

Norfloxacin should be taken no less than 2 hours before or 2 hours after taking antacids or preparations containing iron, zinc, magnesium, calcium or sucralfate.
It should be used with caution in patients with epilepsy, convulsive syndrome of a different etiology, with severe impaired renal and hepatic function. During treatment, patients should receive a sufficient amount of fluid (under the control of diuresis).

Drug interactions

When using the drug, you must consider the interaction with other drugs:
    Reduces the effect of nitrofurans.
    With simultaneous use of cyclosporine norfloxacin, an increase in the concentration of the latter in the blood plasma is observed.
    With simultaneous use of norfloxacin with warfarin increases the anticoagulant effect of the latter.
    With simultaneous use of norfloxacin reduces theophylline clearance by 25%, therefore, with simultaneous use, the dose of theophylline should be reduced.
    While taking norfloxacin and antacid agents or drugs containing iron, zinc, magnesium, calcium or sucralfate, the absorption of norfloxacin is reduced due to the formation of complexones with metal ions (the interval between their intake should be at least 4 hours).
    Simultaneous administration of norfloxacin with drugs that have the potential ability to reduce blood pressure, can cause a sharp decrease. In this regard, in such cases, as well as with the simultaneous introduction of barbiturates, anesthetics, heart rate, blood pressure, ECG indicators should be monitored. Simultaneous use with drugs that reduce the epileptic threshold may lead to the development of epileptiform seizures.

Norfloxacin and Alcohol

Fluoroquinolone preparations are highly effective, but at the same time, highly toxic products. Combining them with alcoholic beverages is strictly prohibited.
Taking alcohol during treatment with a drug can lead to the development of drug-induced hepatitis, nephritis (up to acute renal failure) or toxic damage to the central nervous system (hallucinations, psychosis, convulsions).

Reviews

We picked up some reviews of people using the drug Norfloxacin:
Irina
    Used this medicine recently, as soon as she got sick with cystitis. Saw 2 tablets 2 times a day. Course 3 days. I am very pleased with the result, since I did not accept anything else. Even probiotics forgot to drink, there was no frustration. Then she advised mom when she also had such a problem. I advise, an effective drug!
Martha
    While I drink Norfloxacin 2 weeks, the bacteria disappear in the urine, stop, the bacteria reappear. Apparently you have to drink longer. The urologist says that she was not treated.
Novel
    Good enough antibiotic, as for me. There are contraindications, but they did not appear on me. He took it without a prescription from a doctor in severe cases, when it was necessary to very quickly recover from a cold or treat a throat with sore throat. The drug is relatively normally tolerated by the body, in rare cases drowsiness may occur. At admission I recommend to refuse work requiring increased concentration. Dysbacteriosis was not observed. If this bothers you, you can take either Cetrin or Diazolin. External allergic manifestations are also not observed. When taking I recommend to adhere to the norms specified in the instructions and not to exceed them.

Terms of sell

You can buy Norfloxacin without a prescription.