Nolicin tabs 400mg #20

Nolicin user manual

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Inhibits the effect of bacterial DNA gyrase, thereby preventing its reproduction.
Due to the violation of the synthesis of proteins of microorganisms, leads to their death. It is used in the fight against the majority of gram-negative bacteria (salmonella, shigella, proteus, morganella, enterovirus ...) and with some gram-positive (including staphylococcus).

Release form and composition

Available in film-coated tablets: round, slightly biconvex, orange in color, with a risk on one side (10 pieces in blisters, 1 or 2 blisters in a carton box).
    The active substance - norfloxacin: in 1 tablet - 400 mg.
    Additional components: sodium carboxymethyl starch, magnesium stearate, anhydrous colloidal silicon dioxide, microcrystalline cellulose, povidone, purified water.
Clinico-pharmacological group: antibacterial drug of the fluoroquinolone group.

Nolicin: indications for use

Nolicin tablets are indicated for use by patients for the treatment of the following pathological conditions and their complications:
    Inflammatory processes of the reproductive system - inflammation of the cervix and cervical canal, inflammation of the uterus mucosa, inflammation of the prostate gland in men of bacterial origin;
    Inflammatory diseases of the urinary system - inflammation of the ureters, bladder, kidneys, urethra;
    Inflammation of the mucous membranes of the alimentary canal (stomach and intestines) of bacterial origin - salmonellosis, shigellosis;
    Prevention of sepsis in patients with neutropenia;
    Treatment of gonorrhea.
Nolicin is prescribed for the prevention of recurrence of chronic inflammatory diseases of the urinary organs;
Also indicated as a preventive measure to prevent traveler's diarrhea.

pharmachologic effect of Nolicin

Antimicrobial drug group fluoroquinolone broad-spectrum. The mechanism of action of norfloxacin is associated with the suppression of the enzyme DNA gyrase in the cells of microorganisms, as a result of which bacterial DNA synthesis is prevented.
    Staphylococcus aureus (including Methicillin-resistant strains of Staphylococcus spp.), Staphylococcus epidermidis, Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter spp., Klebsiella spp., And in a case-by-case, Klebsiella spp., In a case-by-case, Citrobacter spp., Klebsiella spp., In a case-by-case, Citrobacter spp., Klebsiella sop. (indole-positive and indole-negative strains), Salmonella spp., Shigella spp., Y. Jesus, Vitelia enterocolitica, Campylobacter jejuni, Aeromonas spp., Plesiomonas spp., Vibrio cholerae, Vibrio parahaemolyticus, Haemophilus, Ichiluschropychilus, Vibrio cholerae, Vibrio cholerae.
The duration of the antimicrobial action is about 12 hours. The half-life of the active component of the drug Nolicin is 3-4 hours. In patients with impaired renal function, some change in the pharmacokinetic parameters of norfloxacin is possible.

Instructions for use

According to the instructions for use, Nolicin is taken orally with a sufficient amount of liquid, preferably on an empty stomach (observing the intervals: at least 1 hour before or 2 hours after eating).
    In acute uncomplicated cystitis - 400 mg 2 times / day for 3-5 days.
    With chronic bacterial prostatitis - 400 mg 2 times / day for 4-6 weeks or more.
    With bacterial gastroenteritis (shigellosis, salmonellosis) - 400 mg 2 times / day for 5 days.
    For uncomplicated gonorrhea - once in a dose of 800-1200 mg or 400 mg 2 times / day for 3-7 days.
    For the prevention of sepsis with neutropenia - 400 mg 2 times / day for 8 weeks.
    For the prevention of recurrent uncomplicated urinary tract infections with frequent exacerbations (more than 3 episodes per year or more than 2 within six months) - 200 mg 1 time per night for a long time (from 6 months to several years). To prevent diarrhea, travelers are recommended to take 400 mg / day for 1 day before departure, during the entire travel time and 2 days after its termination (no more than 21 days).
The average recommended doses of the drug Nolicin - 400 mg 2 times / day. Duration of treatment from 7 to 14 days, if necessary, conduct a longer therapy.

Contraindications

Contraindications to receive Nolicin are:
    Adolescence up to 18 years.
    Hypersensitivity to norfloxacin and other drugs of the fluoroquinolone group.
    Period of pregnancy and breastfeeding.
    Deficiency of glucose-6-phosphate dehydrogenase.
Nolicin is prescribed with extreme caution in atherosclerosis of cerebral vessels, epilepsy, impaired cerebral circulation, epileptic syndrome, allergy to acetylsalicylic acid, renal or hepatic failure.

Side effects

Side effects of treatment with Nolicin include:
    Allergic reactions: rash, urticaria, Stevens-Johnson syndrome, edema.
    On the part of the digestive tract (gastrointestinal tract): bitter taste in the mouth, nausea, vomiting, diarrhea.
    From the side of blood-forming organs: eosinophilia (increase in eosinophils), leukopenia (decrease in leukocytes).
    From the side of the central nervous system: fainting, dizziness, headache, hallucinations, sleep disturbances, irritability.
    From the genitourinary system: dysuria (urination), bleeding, glomerulonephritis.
    Since the cardiovascular system: arrhythmia, hypotension (low pressure), tachycardia.

Pregnancy and lactation

Safety of use during pregnancy and lactation (breastfeeding) has not been studied.
    Nolicin should be prescribed during pregnancy only for health reasons, when the intended benefits to the mother outweigh the potential risk to the fetus.
If necessary, the appointment of the drug during lactation should stop breastfeeding.

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