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Rupafin user manual

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Over the past few decades, the number of people suffering from allergies has increased dramatically. This is largely due to unfavorable environmental conditions. To combat allergies, pharmacological companies produce a variety of medications. They can relieve unpleasant symptoms, such as itching or rashes. One of these drugs is Rupafin.

How Rupafin Works

Rupafin (Rupatadine) is an antihistamine (antiallergic) drug belonging to the second generation. Unlike drugs of the 1st generation, the 2nd generation of antihistamines has a faster action and fewer side effects. The mechanism of Rupafin's work is based on blocking peripheral H1-histamine receptors.
Histamine is a substance produced by the tissues of our body that provides dilation of blood vessels, increases the permeability of their walls. Its main function is to raise an alarm in the tissues and in the whole body if a real or illusory threat to life and health has appeared. In this capacity, there may be, for example, a toxin or an allergen.
H1-histamine receptors are sensitive to histamine (that's why they are called so). When they interact, an allergic reaction of the body begins to develop - a kind of alarm signal.
Blocking these receptors prevents the development of an undesirable reaction. In addition, Rupafin reduces the concentration of histamine in the bloodstream. A feature of the drug is that it selectively acts on the peripheral nervous system, without affecting the central divisions. This sets it apart from many other drugs in this group, such as diazolin or diphenhydramine.
After oral administration, the drug is well absorbed in the digestive tract. The maximum concentration in the blood is reached within 45 minutes. Eating increases the effect of Rupafin by 23%. The drug is almost completely excreted by the body (98–99%), mainly through the gastrointestinal tract.

Release form and composition

Rupafin is available in tablets of 10 mg of the active substance in each. The tablet has a round shape and a pale pink-orange color.
The active ingredient Rupatadina fumarat - 12.8 mg. This corresponds to 10 mg of rupatadine.

Auxiliary components

    pregelatinized starch - 10 mg;
    microcrystalline cellulose - 15 mg;
    the dye red iron oxide (E172) - 0.025 mg;
    Yellow iron oxide dye (E172) - 0.075 mg;
    lactose monohydrate - 61.1 mg;
    magnesium stearate - 1 mg.

Indications for use

There are only two indications for the use of the drug:
chronic idiopathic urticaria;
allergic rhinitis.

Contraindications for Rupafin

The drug has its own contraindications:
    renal and hepatic failure, since rupatadine is metabolized and excreted by the liver, and also partially through the kidneys, and an increase in the load on these organs can lead to deterioration and the appearance of complications;
    hypersensitivity to the components of the tool;
    lactase deficiency, galactose intolerance or weak glucose-galactose adsorption syndrome;
    pregnancy;
    lactation period;
    age up to 12 years.

special instructions

Rupafin should be used with caution in patients with impaired heart function, namely:
    prolongation of the QT interval on the cardiogram;
    proarrhythmic conditions;
    ischemic heart disease;
    clinically significant bradycardia.
The use of the drug in patients over 65 requires control. In addition, it is recommended to refrain from its use simultaneously with statins and grapefruit juice.
    Despite the fact that in normal dosage Rufapin does not inhibit the central nervous system, it should be used with caution when driving vehicles or other mechanisms that require concentration.

Drug interactions

It is also worth paying attention to the drug interaction of Rupafin:
    The combined use of Rupafin and ketoconazole or erythromycin enhances the systemic effect of rupatadine on the body by 2-3 times. At the same time, the QT interval does not change, which occurs when these drugs are used separately.
    The simultaneous use of rupatadine with grapefruit juice enhances the effect of the drug by 3.5 times. This can lead to depression of the nervous system.
    When you take two pills (20 mg), psychomotor and cognitive impairment caused by ethyl alcohol increase.

Rules of admission Rupafin

Apply the drug should be inside 1 time / day. one tablet, regardless of the meal.

Side effect of Rupafin

A drug can have a number of undesirable effects on the part of various organs and systems.
central nervous system
    dizziness;
    concentration disorder;
    asthenia;
    drowsiness;
    headache;
    irritability.
Digestive system
    nausea;
    vomiting;
    dry mouth;
    diarrhea;
    abdominal pain;
    constipation and other dyspeptic disorders.
Respiratory system
    dry nose;
    nose bleed;
    pharyngitis;
    cough;
    pain in the larynx and pharynx;
    rhinitis.
Skin - Rash
Metabolism - Increased appetite
Musculoskeletal system
    arthralgia;
    backache;
    myalgia.
General reactions
    malaise;
    thirst;
    temperature rise;
    weight gain with prolonged use.
Laboratory indicators Increase:
    ALT (marker enzymes for the liver);
    CK (creatine phosphokinase, detected in heart failure);
    AST (the amount of intracellular enzyme aspartate aminotransferase, which usually occurs in myocardial or liver diseases).