Blogir-3 tabs 5mg #30

Blogir-3 instruction for use

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Pharmacology

Histamine H1 receptor blocker (long-acting). It is the primary active metabolite of loratadine. Inhibits the release of histamine and leukotriene C4 from mast cells. Prevents the development and facilitates the course of allergic reactions. Possesses antiallergic, antipruritic and antiexudative action. Reduces capillary permeability, prevents the development of tissue edema, relieves smooth muscle spasm. Virtually no sedative effect and when taken at a dose of 7.5 mg does not affect the speed of psychomotor reactions. Comparative studies of desloratadine and loratadine showed no qualitative or quantitative differences in the toxicity of the two drugs in comparable doses (taking into account the concentration of desloratadine).

Pharmacokinetics

After ingestion begins to be determined in the plasma after 30 minutes. Food does not affect distribution. Bioavailability is proportional to the dose in the range from 5 mg to 20 mg. Plasma protein binding is 83-87%. After a single dose in a dose of 5 mg or 7.5 mg Cmax is achieved in 2-6 hours (an average of 3 hours). Does not penetrate the BBB. Intensively metabolized in the liver by hydroxylation with the formation of 3-OH-desloratadine, coupled with glucuronide, only a small part of the ingested dose is excreted by the kidneys (<2%) and feces (<7%). T1 / 2 - 20-30 hours (on average - 27 hours). When using desloratadine in a dose of 5 mg to 20 mg 1 time / day for 14 days, there were no signs of clinically significant cumulation.

Release form

Tablets for resorption pink, round, flat, interspersed with darker color; with beveled edges and embossed "5" on one side.
1 tab.
desloratadine 5 mg
Excipients: mannitol - 133.5 mg, microcrystalline cellulose - 15 mg, croscarmellose sodium - 6 mg, polacrilin potassium - 5 mg, aspartame - 3 mg, magnesium stearate - 1.7 mg, tutti-frutti flavoring (aromatic substances, maltodextrin, propylene glycol (E1520), modified starch (E1450) - 0.75 mg, iron dye red oxide - 0.7 mg, citric acid monohydrate - qs).

Dosage

Adults and adolescents aged 12 years and older are prescribed by mouth, regardless of food intake, at a dose of 5 mg / day.
Children aged 1 to 5 years old - 1.25 mg 1 time / day, from 6 to 11 years old - 2.5 mg 1 time / day.

Interaction

The study of interaction with ketoconazole and erythromycin did not reveal any clinically significant changes.
Does not affect the effects of ethanol.

Side effects of Blogir-3

Nervous system disorders: headache, hallucinations, psychomotor hyperresponsiveness, convulsions.
On the part of the digestive system: dry mouth, hepatitis.
Others: photosensitivity, myalgia, shortness of breath, feeling tired.

Indications

Seasonal allergic rhinitis, chronic idiopathic urticaria.

Contraindications

Phenylketonuria, pregnancy, lactation, children under 1 year old, hypersensitivity to desloratadine.

Use during pregnancy and lactation

Desloratadine is contraindicated for use during pregnancy and lactation (breastfeeding).

Application for violations of renal function

With caution prescribed desloratadine in severe renal failure.

Use in children

Contraindicated in children under 2 years.

special instructions for Blogir-3

With caution prescribed desloratadine in severe renal failure.

Influence on ability to drive motor transport and control mechanisms

Adverse effects on driving or complex technical devices were noted.

Terms of sell

You can buy Blogir-3 without a prescription.

Reviews about Blogir-3

Irina
Periodically, hives appears in my life, I was saved by suprastinum, often only intramuscular administration helped, so I was looking for a newer and longer-acting drug, because suprastin has an effect for several hours, and other more or less well-known drugs did not work. The pharmacy advised "Blogir-3", the drug is not quite expensive, and there is a urticaria in the testimony. The manual says that the drug is taken 1 time per day.
Alyona
For 35 years I have suffered from pollinosis on pollen of chamomile, quinoa, and wormwood. This year, drowsiness appeared on habitual drugs like "Loratadin", "Claritin" - I sleep 1.5 days after taking one pill. I decided to change the medicine, suggested in the pharmacy "Blogir-3". Began reception - everything seems fine.