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Instruction for Sumamigren

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Migraine - a violation that manifests itself in the form of a strong, often one-sided, chronic, pulsating headache, which mainly affects people of working age from 20 to 40 years. In an attempt to help patients, a group of antifungal drugs was created that do not eliminate the cause of the pain, but only symptomatic agents act.

Drug review

Sumamigren - one of the most common drugs prescribed to patients with bouts of hemicrania (migraine). Manufacturing country - Poland. It is valid 5 years from the moment of production, it is released according to the recipe. The active ingredient in Sumamigren - sumatriptan - the "gold standard" in the treatment of migraine.
    As a result of a large-scale clinical study, where the effect of sumatriptan on migraine attacks was studied, it was found that the effectiveness of this drug in patients exceeds the effectiveness of other antimigraine drugs and is more than 60%.
Sumamigren refers to anti-migraine drugs, triptans І generation. It shows selective agonistic activity on the receptor apparatus of serotonin 5HT1, activating it, almost without interacting with opioid receptors. The drug has the only indication - migraine (at the time of the attack).

Composition and pharmacological properties

The main active ingredient is sumatriptan succinate. Also included in the preparation are auxiliary (inactive substances): lactose monohydrate, croscarmellose sodium, cellulose, silicon dioxide, magnesium stearate.
Hemicrania is often accompanied by vomiting, nausea, photophobia (photophobia), phonophobia, hyperacussion (intolerance to loud sounds), hyperosmia (aversion from any odors), dizziness and disorientation.
The cause of migraine is not fully understood, there are many theories on this topic. At the moment, it is known that vascular dysfunctions in the brain tissues play an important role in the pathogenesis, namely the expansion and release of the extracellular fluid with the formation of edema of the basilar artery.
Based on the pathogenesis of hemikrania, the pharmacodynamics of Sumamigren is to bind in a key-lock manner the active substance with specific receptors that are tropic to serotonin. Sumamigren activates these specific receptors in the endothelium aa. carotis communis, dextra et sinistra. As a result, vasoconstriction of branches aa occurs. carotis and a. basilaris.
It is believed that due to vasodilation in the extracranial and intracranial tissues, including the arachnoid membrane, migraine occurs. Sumatriptan causes vasoconstriction without deterioration of nutrition and oxygenation of the brain.
It is also known that sumatriptan, affecting the nucleus of nervus trigeminus, slows down its activity, thereby reducing the transmission of pain impulse. Thanks to this mechanism, it also has an anti-migraine effect.
The drug is rapidly absorbed after oral administration. After half an hour most of the substance is in the plasma. The half-life is two hours. Since sumatriptan from the gastrointestinal tract is absorbed and not fully metabolized in the body, on average its bioavailability is only 14% (by ingestion).
In 15-20%, sumatriptan binds to plasma proteins. 80% of the substance excreted outside the kidneys. The enzyme monoamine oxidase A transforms the active substance into inactive metabolites in the form of glucuronates and free acids. The expected effect occurs 30 minutes after ingestion.

Indications and limitations of Sumamigren

Appointed to alleviate the condition of patients in periods of migraine attacks with or without aura.
You can not use the drug in such cases:
    Known intolerance to one or more components of the drug, including sumatriptan.
    Disorders of food and oxygen delivery to organs and tissues due to ischemia in history (coronary artery disease, myocardial infarction, vasospastic angina pectoris, stroke, TIA, impaired abdominal circulation, etc.)
    BAD leading to arterial occlusion.
    Heart rhythm disorders.
    Epilepsy in history.
    Hepatargia.
    Essential or secondary hypertension, without control or resistant to therapy.
    Parallel use of drugs - derivatives of ergotamine or ergotamine itself, as well as blockers of the enzyme monoamine oxidase, including a 2-week period after their withdrawal.
    In the treatment of cluster cephalgia in the elderly.
Pregnancy is a contraindication to the appointment of Sumamigren. It is recommended to breastfeed only 12 hours after the last administration of sumatriptan.
Studies were conducted in which about 800 children and adolescents aged 10 to 17 years, suffering from migraine, participated, in which one group took placebo and the other Suma igren. As a result of this study, no significant difference in effects between placebo and the drug was found. The number and frequency of adverse effects is the same in adolescents as well as adults.

How to apply the medicine?

Sumamigren is not used for prevention, but only to alleviate the condition at the time of a migraine attack. The active ingredient equally has its effect at all stages, but it is recommended to take it as soon as possible after the onset of an attack.
You should take a single dose of 50 mg, in individual cases, the dose can be increased to 100 mg, but only at the time of the next attack. The tablets are not chewed, taken whole, regardless of the meal, with a sufficient amount of plain water.
In cases when, after taking one dosage, the symptoms begin to increase again during the first 24 hours after the onset of the attack, an additional dose is allowed, provided that the daily dosage does not exceed 300 mg.

Pharmacological interaction

Sumamigren is able to interact with various substances, potentiating or reducing their effect, thereby increasing the likelihood of unwanted reactions.
It is important to consider interactions with the following substances:
Ergotamine and its derivatives. With this interaction, prolongation of vasospastic reactions is possible. Therefore, it is recommended to take these drugs with an interval of a day or more.
    Parallel administration of monoamine oxidase enzyme inhibitors may cause the development of serotonin syndrome, manifested by mental and visceral instability, hyperreflexia.
    There is no data about the interaction with beta-blockers, alcohol, other anti-migraine drugs.
    With lithium or furozalidone drugs, the toxic effect is enhanced.
    Sorbents reduce the absorption of the drug from the gastrointestinal tract.
    The combination of sumamiren with procarbazine or selegiline is unacceptable.
    The frequency of adverse reactions increases in patients taking St. John's wort.

special instructions

Sumamigren is used only in moments of seizures and is not intended for preventive therapy. If the seizure occurred for the first time, stroke, TIA, headaches of a different etiology (for example: hemi-, ophthalmoplegic, etc.), as well as mental or somatic pathology should be excluded before use.
Before use Sumamigren, you should carefully examine, consult with your doctor to identify the benefits / risks in the following cases:
    Violations of the absorption, transformation and elimination of drugs (ARF, chronic renal failure, hepatargy, etc.).
    Convulsive syndrome in the anamnestic data. The risk of recurrent seizures may increase.
    Hypertonic disease.
    Complicated allergic history. May cause an anaphylactic reaction. Especially with individual intolerance to sulfonamides.
Not appointed:
    Patients with pathologies of the heart and blood vessels, especially in which a history of coronary artery disease, myocardial infarction, TIA, stroke, mesenteriotrombosis and other types of ischemic manifestations. Risk groups should be examined before use. This group includes postmenopausal women, men over 45 years old, people with an increased risk of developing coronary artery disease.
    When galactosemia, as in the composition of the drug is lactose.

Possible adverse reactions and overdose

Possible adverse reactions can be observed practically from all organs and systems and are accompanied by the following clinical and laboratory manifestations:
    Dizziness, sleep disturbance.
    Tremor, nystagmus, scotoma, convulsions, agitation, anxiety.
    Diplopia, temporary loss of vision,
    Dyspeptic phenomena when taking Sumumagren patients have not been fully elucidated.
    Ischemic colitis.
    Dyspnea.
    Temporary increase in blood pressure, changes in heart rate, coronary spasm, Raynaud's syndrome.
    Short-term myalgia, neck stiffness, arthralgia.
    Fatigue, malaise.
    Transaminase elevation.
    Allergic reactions.
When using dosages of more than 400 mg (ie, above the maximum allowable), no other manifestations were observed, except for side effects. In cases of overdose, observe the patient for the next 12 hours. There is no specific treatment. The effect of dialysis on plasma Sumamigren has not been elucidated.

Patient Reviews

Reviews of Sumamigren are ambiguous, there are both positive and negative:
Elena, 32 years old
“Sumamigren is much stronger than any kind of painkillers such as Nurofen, Fanigan and Nimid. She suffered for a very long time, took painkillers in batches until she went to the doctor, and he did not give me these pills. ”
Svetlana, 39 years old
“Only Sumamigren helps, she tried everything. When an attack begins, I immediately run to the pharmacy at any time of the day or night, because an attack can last 5 hours. ”
Julia, 30 years old
“I was at a consultation with a neurologist, they explained to me there that as soon as my head starts to hurt, you need to drink Panadol in pills, if it does not help, you should drink Citramon, if there is no effect again, then Sumamigren. The latter is very strong, I saw it when I was pregnant. And the doctor recommended to drink Glycine. ”
Headache is one of the most frequent complaints of patients. It can be of different nature, localization and periodicity, it can be associated with organic pathology or be functional. According to official data, about 10% of the population suffers from migraine, mostly women.
Before self-treatment with Sumamigren or other similar medicine, other dangerous, sometimes life-threatening conditions that may be accompanied by an unbearable headache must be excluded. The drug has a greater number of side effects, but because of its low cost, it remains one of the anti-migraine drugs purchased.

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