OKI suspension 80mg/2gr #12

OKI suspension user manual

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Release form, composition

Granules for preparation of solution for intake from white to light yellow color, with a characteristic smell of mint.
1 pack (2g)
ketoprofen lysine (ketoprofen lysine salt) 80 mg,
which corresponds to the content of ketoprofen 50 mg
mannitol - 1700 mg, povidone - 132 mg, colloidal silicon dioxide - 3 mg, sodium chloride - 20 mg, sodium saccharinate - 15 mg, ammonium glycyrrhizinate - 20 mg, mint flavoring - 30 mg.
2 g - two-volume three-layer bags (12) - cardboard packs.
2 g - double-layer three-layer bags (20) - cardboard packs.

pharmachologic effect

NSAID, a derivative of propionic acid. It has an analgesic, anti-inflammatory and antipyretic effect. The mechanism of action is associated with inhibition of the activity of COX - the main enzyme metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever.
The pronounced analgesic effect of ketoprofen is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system, as well as the effect on the biological activity of other neurotropic substances that play a key role in the release of pain mediators in the spinal cord brain). In addition, ketoprofen has anti-radicaline activity, stabilizes lysosomal membranes, causes significant inhibition of neutrophil activity in patients with rheumatoid arthritis. Suppresses platelet aggregation.

Pharmacokinetics

When taken orally and rectally, ketoprofen is well absorbed from the gastrointestinal tract. Cmax in plasma when taken orally is achieved in 1-5 hours (depending on the dosage form), when administered rectally, after 45-60 minutes, in a / m administration - in 20-30 minutes, in / in an administration - in 5 minutes.
Plasma protein binding is 99%. Due to pronounced lipophilicity quickly penetrates the BBB. Css in the blood plasma and cerebrospinal fluid remains from 2 to 18 hours. Ketoprofen well penetrates into the synovial fluid, where its concentration 4 hours after administration exceeds that in plasma.
Metabolized by binding to glucuronic acid and to a lesser extent due to hydroxylation.
Excreted mainly by the kidneys and to a much lesser extent through the intestines. T1 / 2 ketoprofen from the plasma after oral administration is 1.5-2 hours, after rectal administration - about 2 hours, after i / m administration - 1.27 hours, after intravenous administration - 2 hours.

Dosage and administration

Set individually depending on the clinical situation.
Apply OKI suspension inside, in / m, in / in (in the form of infusion), rectally or externally in the appropriate dosage forms.

Interaction with other drugs

With simultaneous use of ketoprofen with other NSAIDs increases the risk of erosive and ulcerative lesions of the gastrointestinal tract and bleeding; with antihypertensive drugs (including beta-blockers, ACE inhibitors, diuretics) - it is possible to reduce their action; with thrombolytics - increased risk of bleeding.
With simultaneous use OKI suspension with acetylsalicylic acid, it is possible to reduce the binding of ketoprofen to plasma proteins and increase its plasma clearance; with heparin, ticlopidine - increased risk of bleeding; with lithium preparations - it is possible to increase the concentration of lithium in the blood plasma to toxic by reducing its renal excretion.
With simultaneous use OKI suspension with diuretics increases the risk of renal failure due to a decrease in renal blood flow due to inhibition of prostaglandin synthesis, and against the background of hypovolemia.
With simultaneous use OKI suspension with probenecid, it is possible to decrease the clearance of ketoprofen and its binding to plasma proteins; with methotrexate - may increase the side effects of methotrexate.
With the simultaneous use of warfarin may develop severe, sometimes fatal bleeding.

During pregnancy and breastfeeding

It is contraindicated for use in the III trimester of pregnancy. In the first and second trimester of pregnancy, the use of ketoprofen is possible in cases where the potential benefit to the mother outweighs the potential risk to the fetus.
If you need ketoprofen during lactation, breastfeeding is recommended to stop.

Side effects of OKI suspension

On the part of the digestive system: epigastric pain, nausea, vomiting, constipation or diarrhea, anorexia, gastralgia, abnormal liver function; rarely - erosive and ulcerative lesions of the gastrointestinal tract, bleeding and perforation of the gastrointestinal tract.
From the side of the central nervous system: headache, dizziness, tinnitus, drowsiness.
On the part of the urinary system: renal dysfunction.
Allergic reactions: skin rash; rarely - bronchospasm.
Local reactions: when used in the form of candles, irritation of the rectal mucosa, painful defecation is possible; when applied in the form of a gel - itching, skin rash at the site of application.

Indications for OKI suspension

Articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout); symptomatic treatment of inflammatory-degenerative diseases of the musculoskeletal system (periarthritis, arthrosinovitis, tendonitis, tendosynovitis, bursitis, lumbago), back pain, neuralgia, myalgia. Uncomplicated injuries, in particular sports, dislocations, sprain or rupture of ligaments and tendons, bruises, post-traumatic pain.
As part of a combination therapy of inflammatory diseases of the veins, lymph vessels, lymph nodes (phlebitis, periphlebitis, lymphangitis, superficial lymphadenitis).

Contraindications

For oral administration: erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, "aspirin triad", marked impairment of liver and / or kidney function; III trimester of pregnancy; age up to 15 years (for retard tablets); hypersensitivity to ketoprofen and salicylates.
For rectal use: a history of proctitis and bleeding from the rectum.
For external use: weeping dermatosis, eczema, infected abrasions, wounds.

special instructions

With extreme caution used in patients with liver and kidney diseases, gastrointestinal diseases in history, dyspeptic symptoms, immediately after serious surgical interventions. In the process of treatment requires systematic monitoring of liver and kidney function.

Reviews

Vladimir
This drug was prescribed by a neurologist for neck pain (osteochondrosis). I have been using it for 5 years already. The active substance is kotoprofen in the form of a solution. Sachets are dual-core, with the expectation of adults and children. The granules dissolve well in water, the taste is unsightly, refreshing, quite tolerable. After taking it begins to act after about 20-30 minutes, preferably on an empty stomach, so faster. Removes sharp pain. Acts with severe pains of 3 hours, weak removes immediately and for a long time. In the package 20 bags, enough for about a month with occasional pain.
Olga
I first met this pain medicine in Italy and it became my magic wand. In Italy it is the most popular and effective anesthetic drug. Everyone knows if something bothers you, accept OKI and the pain will recede. This fame and popularity is no accident, because it is produced in Italy by the pharmaceutical company "Domp" in the city of Aquila. The active substance OKI is ketoprofen. The effect after taking OKI suspension is almost instant. Pain relieves like a hand after a minute. Most likely this happens because you drink OKI in the form of a powder dissolved in water, therefore the effect on the body is very fast. Not like with a pill, I took and waited 10-15 minutes, or even more. Packing at OKI is very convenient and not bulky. In a rectangular, cardboard box there are 30 double bags with a granular preparation and instructions for use. They are doubled because if you open only one compartment of the bag, it will be a children's dose. You open both branches at once, you get an adult dose. In any case, if you look closely at the bag, then it is simply not possible to make a mistake. Everything is written on it, where is the full dose, and where is the child. There is even a cut line. Need a child dose, made the cut to the middle and used the contents, the remaining half is kept tightly closed. The contents of the bag must be dissolved in a small amount of water, literally 100 grams and drunk. The taste of the drug is very pleasant, fresh, menthol.

Terms of sell

You can buy OKI suspension without a prescription.