OKI supp 160mg #10

OKI user manual

You can buy OKI on this page

In the composition of the Suppositories "OKI" as the main active element is lysine ketoprofen. In addition, in the production of this medication, some additional substances are used - semi-synthetic glycerides.
Packaged drug in strips of 5 pieces, and in cardboard boxes.

Pharmacological properties

According to the instructions, Suppositories "OKI" belong to the category of anti-inflammatory nonsteroidal drugs, are derived from propionic acid.
The described pharmacological agent has an analgesic, antipyretic and anti-inflammatory effect. The principle of its influence on the body is due to the inhibition of the functionality of COX - the main enzymes of arachidonic acid metabolism, which is a precursor of prostaglandins, which play a major role in the pathogenesis of the inflammatory process, fever and pain syndrome.
The pronounced analgesic effect of the main active element is associated with two mechanisms: peripheral action (indirectly, by suppressing the synthesis of prostaglandins) and central action (due to inhibition of prostaglandin production in the peripheral and central nervous systems, as well as impact on the biological activity of other neurotrophic substances playing a fundamental role in release of provocateurs of pain in the spinal cord. In addition to all the above, ketoprofen has an int nsivnoy antibradikininovoy activity, it helps normalize the functions of the lysosomal membranes, causing a significant reduction in neutrophil activity in people with rheumatoid arthritis, as well as rapidly inhibits platelet aggregation.
This confirms the instructions for use for Suppositories "OKI".
With rectal administration, this active substance is well absorbed from the alimentary canal, reaching a maximum concentration in the body in the range of 1-5 hours, and with rectal administration, after about 60 minutes.
Plasma protein binding - 99%. As a result of pronounced lipophilicity, the drug is able to quickly penetrate the BBB. High concentrations of the active element in the cerebrospinal fluid and plasma persist up to 18 hours. Ketoprofen enters the composition of the synovial fluid, where 4 hours after administration, its level exceeds the concentration in plasma.
The drug is metabolized by binding to glucuronic acid and to a small extent by hydroxylation. Its removal from the body occurs mainly through the kidneys and to a lesser extent through the intestines. Plasma half-life after rectal administration is approximately 2 hours.

Indications for administration of the drug

Suppositories "OKI" are prescribed by doctors for the following diseases:
    pathologies involving articular syndrome (osteoarthritis, rheumatoid arthritis, gout, ankylosing spondylitis);
    symptomatic therapy of inflammatory and degenerative diseases of the musculoskeletal system (periarthritis, tendonitis, arthrosinitis, tendosynovitis, lumbago, bursitis);
    pain in the spine, myalgia, neuralgia of different nature of origin;
    uncomplicated injuries, such as sports, sprains, dislocations, ruptures of ligaments and tendons, post-traumatic pain, bruises;
    in the complex treatment of inflammatory diseases of the veins, lymph nodes, lymphatic vessels (phlebitis, lymphangitis, periphlebitis, superficial lymphadenitis).

Dosing regimen

Suppositories "OKI" are determined individually, taking into account the complexity of the specific pathological process. At the initial stages of therapeutic interventions, it is recommended to use the drug in oral forms or in the form of intramuscular injection, after which it passes to the rectal dosage form. The maximum dosage and using rectal suppositories is 300 mg per day.

Adverse Reactions

Like all anti-inflammatory nonsteroidal drugs, the drug "OKI" has a wide list of side effects, which include:
    Digestive system: pain in the epigastric region, nausea, vomiting, constipation or diarrhea, gastralgia, anorexia, abnormal liver function, erosive or ulcerative lesions of the digestive organs, perforation and bleeding in the digestive tract.
    CNS: dizziness, tinnitus, headache, and also drowsiness.
    Urinary system: renal dysfunction, urinary retention.
    Allergic reactions: skin rash, development of bronchospasms, angioedema.
    Reactions of a local nature: when used in the form of Suppositories, symptoms of irritation of the mucous membranes of the rectum, painful bowel movements, itching in the anorectal region may occur.
Suppositories "OKI" are contraindicated for use in proctitis and bleeding from the rectum (in the past).

Use OKI during pregnancy and lactation

The described medical drug is contraindicated for use in the third trimester of pregnancy. Until this period, the use of ketoprofen is permitted only in cases where the expected benefit to the patient outweighs the potential threat to the health of the unborn child.
If necessary, the use of the drug during lactation is recommended to stop.

Use of the drug for disorders of the kidneys and liver

Pronounced disorders of the liver and kidneys are a contraindication for rectal administration of the drug.
The use of the drug "OKI" is allowed only after the child reaches the age of 15.

Special instructions

With caution, the drug in rectal dosage form is used in patients with pathologies of the urinary and digestive systems, gastrointestinal diseases in the past, dyspeptic phenomena, after serious surgical interventions. During therapy, systematic monitoring of the functional properties of the liver and kidneys is necessary.

Drug interactions

The combined use of rectal suppositories of the drug "OKI" with other NSAIDs increases the potential risk of developing erosive or ulcerative lesions of the mucous membranes of the digestive system and the occurrence of bleeding.
When used simultaneously with antihypertensive drugs (including ACE inhibitors, beta-blockers, diuretics), it is possible to reduce their therapeutic effects.
During use with thrombolytic agents, the risk of bleeding significantly increases.
With concomitant use with acetylsalicylic acid, the binding of the main active ingredient of the drug "OKI" with plasma proteins and an increase in its plasma clearance can be reduced.
When used with ticlopidine and heparin, the likelihood of bleeding increases; with lithium medicines - it is possible to increase the concentration of lithium in the blood to toxic levels due to a decrease in its renal excretion.
With simultaneous use with diuretics increases the likelihood of renal failure as a result of reduced blood flow in the renal vessels, due to inhibition of the production of prostaglandins, as well as against the background of hypovolemia.
When combined with probenecid, ketoprofen clearance and its binding to plasma proteins may decrease; with methotrexate - side effect of methotrexate is enhanced.
With the simultaneous use of warfarin, severe and in some cases fatal bleeding may occur.

Instructions for use Suppositories "OKI" in gynecology

Due to the fact that the drug drug perfectly eliminates pain and inflammation, in the form of rectal suppositories it is widely used in clinical gynecological practice.
Suppositories "OKI" in gynecology are assigned to women in the following cases:
    painful menstruation;
    before the establishment of the intrauterine device or after this manipulation;
    endometriosis;
    inflammatory processes in the female appendages;
    ovarian cyst;
    conditions after surgery in the genital area;
    cervical erosion.

Reviews of Suppositories "OKI" in gynecology

To date, non-steroidal anti-inflammatory substances are the most appropriate and safe means to relieve pronounced pain syndromes. They are widely used in almost all categories of patients and for any diseases that are accompanied by severe pain.
Suppositories "OKI", according to reviews, among all the products from this pharmacological category are particularly popular among patients and occupy a leading position in the ranking of NVPS. This is due, primarily, to the fact that it is a relatively new drug, which today is used in many medical fields. It is especially convenient that this medicine is produced not only in the form of tablets and solutions for intramuscular administration, but also in the form of rectal suppositories, which make the “OKI” universal.
Patients left a lot of positive feedback about it. They note that this drug effectively relieves any pain, for example, in case of joint diseases. In addition, the medicine helps well with various muscle pains, with gynecological diseases, with pain after surgical manipulations.

What else there are reviews about the use of Suppositories "OKI" in gynecology?

There are practically no negative comments from women about the drug, with the exception of those that reflect information about adverse reactions from its use. Rectal suppositories, in contrast to oral forms of the drug, almost do not cause systemic side effects, which cannot be said about local ones. Patients noted soreness in the anus during bowel movements, as well as itching and burning of the rectal mucosa.

Termsf of sell

You don't need a prescription to buy OKI.