Nimesil granules 100mg 2gr #30

User manual for Nimesil

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The balanced composition of the drug allows it to be used both for long-term therapy, and for a course of symptomatic treatment or a single use in order to stop severe pain.

Release form and composition

Clinico-pharmacological group: NSAIDs, a selective inhibitor of COX-2. Nimesil is available in the form of granules for the preparation of suspensions for oral use.
    The active ingredient is the substance nimesulide. The drug is available in the form of packages of 2 grams, the number of packages per package - 9, 15 and 30 pcs.
The quantitative content of the active substance in one bag is 100 mg. Components such as sucrose, orange flavoring, citric acid, ketomacrogol act as auxiliary substances.

pharmachologic effect

Nimesil provides a pronounced analgesic, antipyretic and anti-inflammatory effect. The principle of operation of this product is to inhibit the synthesis of prostaglandins. Nimesil inhibits the synthesis of prostaglandins at the site of inflammation more effectively than in the gastric mucosa or in the kidneys.
With long treatment, the product is fairly well tolerated. Its action develops relatively quickly, aided by the properties of the dosage form. The duration of the effect is approximately 6 hours.

Instructions for use

Nimesil is used only for the treatment of patients older than 12 years.
    Nimesil is accepted inside, on 1 bag (100 mg of Nimesulide) 2 times / days. The drug is recommended to be taken after meals. The contents of the bag poured into a glass and dissolved in about 100 ml of water. The prepared solution is not subject to storage.
    The maximum duration of treatment with nimesulide is 15 days. To reduce the risk of unwanted side effects, use the minimum effective dose of the minimum short course.
Adolescents (aged 12 to 18 years): based on the pharmacokinetic profile and pharmacodynamic characteristics of nimesulide, there is no need to adjust the dose in adolescents.
Elderly patients: in the treatment of elderly patients, the need for adjusting the daily dose is determined by the doctor based on the possibility of interaction with other drugs.
Patients with impaired renal function: on the basis of pharmacokinetic data, there is no need for dose adjustment in patients with mild and moderate forms of renal failure (CC 30-80 ml / min).

Contraindications for Nimesil

It is forbidden to use the drug in such cases:
    Hepatotoxic reactions of the body to nimesulide in history.
    Simultaneous treatment with other drugs that have a hepatotoxic effect (especially from the group of UIPs).
    Inflammatory processes in the intestine in the acute phase (Crohn's syndrome, ulcerative colitis).
    Recovery period after coronary artery bypass surgery.
    Fever accompanying colds and ARVI.
    The combination of bronchial asthma, polyposis of the paranasal sinuses or nose with a relapsing course and intolerance to NSAIDs in history.
    Hypersensitivity to the active basis (nimesulide) or an auxiliary component of Nimesil.
    Hyperargic reactions of the body in history: rhinitis, urticaria, bronchospasm, laryngism, associated with the intake of any drug from the group of NSAIDs, including nimesulide.
    Aggravation of gastric or duodenal ulcers;
    Ulcer with a bleeding or perforation in the anamnesis;
    Cerebrovascular and other bleedings in the anamnesis;
    Renal failure in severe;
    Confirmed hyperkalemia;
    Liver disease in the acute phase;
    Liver failure;
    Bleeding disorders;
    Violation of blood clotting of a severe nature;
    Severe heart failure;
    Pregnancy, lactation;
    Children under 12;
    Drug addiction, alcoholism.
With care, Nimesil is prescribed for the following pathologies and factors:
    heart failure of any degree;
    severe hypertension;
    type 2 diabetes;
    CHD;
    hereditary intolerance to fructose;
    glucose-galactose malabsorption;
    arterial disease (peripheral);
    Helicobacter pylori infection;
    creatinine clearance less than 60 ml / min;
    long-term treatment of NSAIDs;
    sucrose-isomaltose deficiency;
    dis- or hyperlipidemia;
    cerebrovascular pathology;
    severe somatic diseases;
    elderly age;
    smoking.

Pregnancy and lactation

Like other NSAID drugs that inhibit prostaglandin synthesis, nimesulide can adversely affect pregnancy and / or embryo development and can lead to premature closure of the ductus arteriosus, hypertension in the pulmonary artery system, impaired kidney function, which can lead to renal failure with oligodiramnia, to increased risk of bleeding, reduced uterine contractility, the occurrence of peripheral edema. In this regard, the drug is contraindicated during pregnancy and during breastfeeding.

Side effects

When using this drug are possible such side effects:
    Allergic manifestations - rash, itching, excessive sweating, hypersensitivity, dermatitis, erythema, urticaria, anaphylactic shock, angioedema, Stevens-Johnson syndrome, Lyell's syndrome.
    The hematopoietic system is anemia, hemorrhagic syndrome, eosinophilia, thrombocytopenic purpura, thrombocytopenia.
    The digestive system - diarrhea, vomiting, nausea, constipation, gastritis, flatulence, abdominal pain, tarry stools, dyspepsia, stomatitis, stomach ulcers, stomach and intestinal bleeding, hepatitis, jaundice
    Central nervous system - nervousness, dizziness, fear, nightmares, headache, encephalopathy, drowsiness.
    The organs of vision - blurred, blurred.
    Cardiovascular system - hypertension, tachycardia, "flushes", the lability of blood pressure.
    The urinary system - hematuria, dysuria, urinary retention, oliguria, interstitial nephritis, renal failure.
    Respiratory system - shortness of breath, bronchospasm, recession of bronchial asthma.
Most often, when using non-steroidal anti-inflammatory drugs (NSAIDs), there is a violation in the gastric tract. Clinical studies have shown that NSAIDs with prolonged use (especially in large doses) may contribute to thrombosis of the arteries (myocardial infarction or stroke).

special instructions

Studies showing the ability to drive a car or other vehicles, were not conducted. If, while taking the medication, there is increased drowsiness and dizziness, you should refrain from driving and production machines.
If you have flu-like symptoms while you are taking Nimesil, severe dizziness, stomach pain, vomiting, dark urine, you should stop taking the drug, consult your doctor and switch to another group of painkillers and anti-inflammatory drugs.

Overdose

Based on reviews of Nimesil, we managed to identify the following symptoms of overdose with medication: drowsiness, apathy, pain in the epigastric region, nausea, vomiting. Gastrointestinal bleeding, acute renal failure, high blood pressure, respiratory depression, anaphylactoid reactions and coma are also possible.

Storage conditions

Keep the drug in a dark, dry place at room temperature. Shelf life - 2 years.

Reviews

Olga
Accidentally “opened” Nemesil when a knee ached, saw only when it was necessary to go for a long distance or some work with a load was ahead. Highly!!! I am satisfied with his action, now there is always in the first-aid kit, although the knee has not been disturbed for three years already (there was no longer any treatment). On the recommendation of the drug, relatives and acquaintances soothe acute tooth and joint pain.
But I tell everyone that it is only temporary and urgent before consulting a doctor! Neighboring cottage for 75 years, she takes Nimesil when she can't sleep at night because of pain in her leg, and even when she comes in the fall to get mushrooms. Also very pleased with his action. Due to significant contraindications, we do not take the drug all the time, but as a magic wand it cannot be replaced!
Anastasia
I often suffer from back pain. She has already applied to doctors, and various procedures have passed, all in vain. So I can only drink pain reliever. I also tried a lot of drugs, even Nise. Nothing really helped. Here's a friend advised Nimesil. Very good and not expensive drug. As soon as I get sick, I don’t wait and immediately accept Nimesil.

Terms of sell

The prescription is not required to buy Nimesil.