Nemulex granules 100mg #30

Nemulex instruction

You can buy Nemulex here

Nemulex allows you to eliminate painful symptoms, while not curing the disease itself, which provoked it. It is prescribed to patients suffering from rheumatoid arthritis, nailgia, algomenorrhea, osteoarthritis or bursitis.

Release form and composition

Nemulex powder is yellow with a pleasant smell and orange flavor. Packed in sealed sachets.
    Dosage 1 package - 100 mg of the main active ingredient Nimesulide in granules.
    Along with it, the preparation contains: 100 mg of macrogol, 19 mg of citric acid (anhydrous), 40 mg of colloidal dioxide, 1721 mg of sucrose, 20 mg of orange flavor.
To take the medicine inside it is necessary to dissolve the powder granules in water. The resulting suspension should be applied according to the instructions in accordance with the doctor's prescriptions.

Pharmacological effect

Nemulex is a broad-spectrum medicine that has a diverse effect on the human body. In the complex, the drug has antipyretic, anti-inflammatory, analgesic and antiaggregate (aggregation - cell sticking into a large multicellular formation) effects. Medication is attributed to nonsteroidal anti-inflammatory drugs.
Unlike all other drugs of this group, the drug Nemulex selectively has a suppressive effect (inhibits) on COX-2, slows down and completely stops the process of synthesizing prostaglandins in the area of ​​inflammation. At the same time, the influence of Nemulex on COX-1 is much less pronounced. As a result, less frequently than other NSAIDs, side effects develop due to inhibition of prostaglandin synthesis in healthy cells and tissues.

Indications for use

    tendovaginitis (inflammation of the tendon);
    algomenorrhea (painful menstruation);
    osteoarthrosis;
    arthritis, including rheumatoid (chronic systemic disease of the joints);
    myalgia (muscle pain);
    arthralgia (joint pain);
    bursitis (inflammation of the periarticular mucous membrane);
    toothache and headache;
    postoperative and traumatic pain.
The drug has no therapeutic effect, removes only the pain and inflammation of an episodic nature.

Contraindications

Before starting drug therapy, the patient is advised to consult with a physician and familiarize himself with the instructions in detail. Nemulex is contraindicated in the following conditions:
    Chronic heart failure in the stage of decompensation;
    Crohn's disease;
    Severe liver or kidney disease, accompanied by liver or kidney failure;
    Pregnancy 1 and 3 trimester and breastfeeding period;
    Severe cases of bronchospasm and depression of respiratory function in history;
    Tendency to bleeding, hereditary blood disorders - vasculitis, hemophilia;
    Recently transferred operations;
    Age in children under 12 years;
    The exacerbation of chronic diseases of the digestive canal, accompanied by erosive or ulcerative lesions of the mucous membranes;
    Intolerance to acetylsalicylic acid or aspirin ulcer;
    Bronchial asthma;
    Nasal polyps;
    Individual intolerance to medication.
The drug is especially prescribed for people with coronary heart disease, diseases of the cardiovascular system, diabetes.

Use during pregnancy and lactation

During these periods, as well as during pregnancy planning, the use of the drug should be abandoned.

Dosage and method of use

The instructions for use indicate that Nemulex is taken orally. The contents of 1 sachet of granulate is dissolved in 80-100 ml of water.
    The recommended dose for adults and adolescents aged 12-18 years is 100 mg (1 sachet) 2 times / day after meals. The maximum daily dose for adults and adolescents aged 12-18 years is 200 mg.
    Elderly patients dose reduction is not required.
    Patients with chronic renal failure require a reduction in the daily dose to 100 mg.
To minimize the risk of adverse reactions, the drug should be prescribed in the minimum effective dose for as short a period as possible. The maximum duration of the drug is 15 days.

Side effects

On the background of drug treatment in patients may develop side effects:
    Eye reactions: visual impairment.
    Allergic reactions: urticaria, angioedema, hypersensitivity reactions, swelling of the face, anaphylactoid reactions.
    Reactions from the side of respiration: bronchospasm, shortness of breath.
    Reactions of the nervous activity: a feeling of fear, dizziness, nervousness, headache, drowsiness, nightmares, encephalopathy.
    Reactions from blood circulation: tachycardia, arterial hypertension, hot flashes, hemorrhages.
    Reactions from blood formation: eosinophilia, anemia, thrombocytopenia, purpura, pancytopenia, prolongation of bleeding.
    Reactions from the urogenital sphere: dysuria, edema, hematuria, oliguria, hyperkalemia, urinary retention, interstitial nephritis, renal failure.
    Skin reactions: skin rash, pruritus, increased sweating, dermatitis, erythema, exudative erythema multiforme, epidermal toxic necrolysis.
    Reactions from the digestive system: nausea, diarrhea, vomiting, flatulence, constipation, gastritis, stomatitis, abdominal pain, tarry stools, bleeding, duodenal ulcer or jaundice, increases in liver transaminases, fulminant hepatitis, cholestasis.
    Other reactions: weakness, hypothermia.

Overdose

Signs of an overdose of the drug are:
    nausea;
    vomiting;
    drowsiness;
    pressure increase;
    respiratory depression;
    bleeding from the digestive tract;
    apathy.
There is no antidote for this remedy. It is necessary to do a gastric lavage and drink a laxative, in addition to this is the reception of activated charcoal.
The state of the liver and kidneys is monitored.

special instructions

Before you start using the drug, read the specific instructions:
    In case of deterioration in renal function, the drug should be discontinued.
    If the drug is used for more than 2 weeks, monitoring of liver function indicators is necessary.
    It is necessary to stop taking the drug in case of fever or the development of flu-like symptoms on the background of his reception.
    Gastrointestinal bleeding or an ulcer / perforation of the stomach or duodenum may develop at any time with the use of the drug and not be accompanied by clinically pronounced symptoms (including pain syndrome). If gastrointestinal bleeding or ulceration occurs, the drug should be withdrawn.
    To reduce the risk of side effects, it is necessary to use the drug in the lowest effective dose with the shortest duration. If the patient’s condition does not improve, treatment should be stopped.
    When patients taking Nemulex, symptoms that indicate liver damage (eg, anorexia, nausea, vomiting, abdominal pain, fatigue, dark urine), or increased activity of hepatic transaminases, the drug should be canceled. It is not recommended to appoint such patients to Nemulex in the future.
    In patients with cirrhosis of the liver or with renal insufficiency with hypoalbuminemia or hyperbilirubinemia, the binding of nimesulide is reduced.
    Elderly patients most often develop side effects when taking the drug, including gastrointestinal bleeding, perforation, impaired function of the heart, kidneys and liver. Therefore, regular clinical monitoring of the patient’s condition is recommended.
If the use of the drug causes adverse effects from the central nervous system and sensory organs, then patients should refrain from driving vehicles and activities that require high concentration of attention and psychomotor speed.

Drug interactions

When using the drug, you must consider the interaction with other drugs:
    Nemulex can enhance the effects of cyclosporine on the kidneys.
    Physiological concentrations of unsaturated fatty acids do not affect the binding of nimesulide to serum albumin.
    At therapeutic concentrations, the binding of nimesulide was not affected by warfarin, furosemide, glibenclamide, digitoxin.
    The drug Nemulex is not recommended at the same time as diuretics, which have a damaging effect on renal hemodynamics.
    In the presence of nimesulide, the free fractions of methotrexate can significantly increase.
    The concentration of lithium in the plasma increases while taking lithium preparations and the drug Nemulex.
    The drug Nemulex in therapeutic doses orally for a short period does not change the serum profile of digoxin in patients with mild heart failure.
    Nemulex has no effect on drugs that affect blood glucose concentration and glucose tolerance in patients with diabetes mellitus treated with sulfonylurea derivatives.
    There is evidence that nimesulide can reduce the bioavailability of furosemide, compete for binding to plasma proteins of fenofibrate, salicylic acid, and tolbutamides. Nemulex can replace salicylic acid and furosemide (but not warfarin) in plasma proteins.
    With simultaneous use of the drug Nemulex with corticosteroids, serotonin reuptake inhibitors increases the risk of gastrointestinal bleeding.

Reviews

We picked up some reviews of people using Nemulex powder:
Sasha
    Well misbalances. The main thing - quickly, an hour no more. Drinking from rheumatoid arthritis. Not constantly, but with increased inflammation of the joints.
Elena, doctor
    Excellent working generic, besides containing less sugar than the original version, which is important in some patients with carbohydrate metabolism. The price is normal compared to the same original. Efficiency showed no worse. Side effects - like all Nimesulides, no more and no less.
Anton
    Wonderful drug. He sprained his leg strongly, with all the consequences, the swelling was strong, the bruise was hellish pain - it was impossible to step on one leg After a pill of diclofenac and two small bags of non-flex, it somehow began to move. The pain specifically subsided.

Storage conditions and shelf life

Pellets should be kept away from children in a cool dry place. The expiration date of the drug is indicated on the package and does not exceed 3 years from the date of manufacture.

Terms of sell

You can buy Nemulex without a prescription.