Next Uno Express caps 200mg #20

Instruction for Next Uno Express

You can buy Next Uno Express here

Composition and action

The capsule shell consists of the following components:
    gelatin;
    glycerol;
    sorbitol;
    methyl parahydroxybenzoate;
    purified water;
    dye red E-129.
The capsules are oval and red in color, but they are transparent. Inside of them is a clear liquid, which is necessary so that the active substances are absorbed faster into the blood.
Contents of one capsule:
    active ingredient (ibuprofen - 200 mg);
    excipient (povidone 17 PF - 30 mg, macrogol 600 - 414.628 mg, tocopherol acetate - 0.372 mg).
The mechanism of action of Next Uno Express is aimed at inhibiting the activity of the arachidonic acid enzyme (COX), which is further transformed into prostaglandins. Those, in turn, occupy an important place in the development of fever, various inflammatory processes and pain.

Release form

Therapeutic agent is available in the form of capsules of 10-20 pieces. in one pack.

Pharmacodynamics

The active ingredient of Next Uno Express is a derivative of propionic acid and is considered an anti-inflammatory nonsteroidal agent. Its task is to inhibit the synthesis of prostaglandins. Thus, ibuprofen has a rapid effect on the pain center and relieves its manifestations. In addition, the painkiller has antipyretic and anti-inflammatory properties, which makes it possible to use the medicine in the treatment of catarrhal pathologies.

Pharmacokinetics

The active ingredient of the capsules is absorbed by the walls of the stomach almost 80%. The body's ability to break down ibuprofen deteriorates somewhat if the medicine is taken after eating food. The maximum concentration of ibuprofen in the blood is achieved if you drink it on an empty stomach after 45 minutes. If you take the medicine after a meal, then its maximum concentration in the body occurs in 1.5-2 hours.
Ibuprofen interrelates by 90% with blood proteins. The substance also undergoes postsystem and presystemic metabolism in the liver. Next Uno Express leaves the body through the urinary system and partly through the intestines.

Indications for use

The purpose of Next Uno Express should be a doctor and only if the patient has:
    degenerative-inflammatory pathologies of the joints and spine (gout, rheumatoid arthritis, sciatica, osteoarthritis, ankylosing spondylitis, bursitis, etc.);
    traumatic inflammation of the muscles and musculoskeletal system;
    neurological diseases (migraine, chronic stress, etc.);
    infectious and inflammatory diseases of the respiratory system (flu, cold, etc.).
Another drug is prescribed to patients who are worried about severe tooth and headache, as well as fever (temporary increase in body temperature).

Application and dosage of Next Uno Express

Next Uno Express can be administered to both adults and children over the age of 12 years. It is taken orally after a meal, one capsule (200 mg) 3 or 4 times a day. Capsules should be washed down with a glass of pure non-carbonated water.
To get a quick therapeutic effect, the dosage of Next Uno Express can be increased before taking two capsules 3 times a day, i.e. up to 400 mg per time. Upon reaching the desired therapeutic effect, the total dosage of the drug is reduced to 600-800 mg per day. The maximum allowable daily dosage for adults is no more than 1200 mg (6 capsules), and for children from 12 to 18 years old - 800 mg.

Contraindications when using the drug Next Uno Express

Next Uno Express can not be used to those people who have the following problems:
    bleeding from the digestive tract;
    asthma;
    polyposis of the paranasal sinuses and nose of a recurring nature;
    hypersensitivity of the body to the active substance and to other components of the therapeutic agent (allergic reactions);
    diseases associated with impaired blood clotting (hemophilia, hemorrhagic diathesis, etc.);
    erosive and ulcerative lesions of the gastrointestinal tract (ulcerative colitis, Crohn's disease, stomach ulcers and peptic);
    intracranial hemorrhage;
    progressive kidney disease and renal failure, occurring in severe form;
    gastrointestinal diseases (gastritis, atony, pneumatosis, etc.);
    liver pathologies (hepatitis, hepatic vein thrombosis, liver cirrhosis, piletrombosis and pylephlebitis);
    hyperkalemia;
    acute heart failure.
In addition, the tool can not be taken by people who have recently undergone coronary artery bypass surgery, pregnant women in the third trimester and lactating women.

Side effects

There are no side effects when used correctly, but in case of prolonged use the following disorders may occur in a person:
    diarrhea, flatulence, nausea, heartburn, pancreatitis, constipation, hepatitis, loss of appetite, vomiting, and abdominal pain;
    dry mouth, accompanied by pain, aphthous stomatitis and the appearance of ulcers on the mucous membrane of the gums;
    bronchospasm, shortness of breath, possible recurrence of asthma (if there is such a disease);
    noise or tinnitus and hearing loss;
    nervousness, anxiety, insomnia, depression, irritability, hallucinations, clouding of consciousness, drowsiness, dizziness, and headache;
    exacerbation or development of tachycardia and heart failure;
    increase in blood pressure;
    bleeding gums;
    allergic nephritis, cystitis, polyuria, and acute renal failure;
    leukopenia, aplastic and hemolytic anemia, pancytopenia and agranulocytosis;
    double vision, loss of clarity of vision, swelling of the conjunctiva of the eyes and eyelids, accompanied by dryness and irritation of the mucous membrane, toxic amblyopia;
    skin rashes, angioedema, pruritus, fever, allergic rhinitis, toxic epidermal necrolysis, eosinophilia, and anaphylactic shock;
    increased sweating.
Perhaps the development of ulcerative tumors on the mucous membrane of the gastrointestinal tract and the appearance of gastrointestinal bleeding. In the event of side effects from the use of Next Uno Express, it is recommended to stop taking it and to see a doctor as soon as possible.

Overdose

In case of overdose, the following symptoms may occur:
    abdominal pain;
    drowsiness;
    nausea and vomiting;
    clouding of consciousness;
    depression, depression;
    headache;
    noise in ears;
    a sharp drop in blood pressure;
    tachycardia and bradycardia;
    atrial fibrillation of the heart;
    acute renal failure.
In severe cases, respiratory arrest can be observed and even a coma can occur.

special instructions

During the course of treatment, it is necessary to monitor the blood condition and monitor the functioning of the kidneys and liver. If problems arise in the activity of the organs of the gastrointestinal tract, an analysis of fecal masses for hidden blood and a general blood test should be carried out. If necessary, you can do esophagogastroduodenoscopy. To prevent the development of intestinal diseases, taking medication is recommended to be combined with the use of Misoprostol.
Patients who suffer from heart failure or persistent increase in blood pressure, you must be careful when using a therapeutic agent and be sure to undergo regular consultations with the doctor who prescribed Next Uno Express. This is due to the fact that such patients may have swelling of the arms and legs while taking the drug.
    People who have any type of allergy or bronchial asthma should also take Next Uno Express with extreme caution, since it can contribute to the development of bronchospasm or anaphylactic shock.
The course of treatment with the use of Next Uno Express should be as short as possible, since a long-term administration may contribute to the appearance of a stroke and other problems with the vascular-cardiac system.
In addition, ibuprofen, which is part of Next Uno Express, has an antiaggregant effect on the blood, i.e., affects its ability to clot. Therefore, patients who have problems with blood clotting should take into account all the risks associated with the use of Next.

Can I take during pregnancy and lactation

Next Uno Express can be taken by women in the I and II trimesters of pregnancy, but only if the possibility of developing complications for the fetus is minimal, and the health benefits of the mother are substantial.
During lactation, ibuprofen is allowed, but in a small amount. If a long course of treatment with such a remedy is necessary, then it is recommended to stop breastfeeding.

Use in childhood

The tool can be taken by children over the age of 12 years.

In case of impaired renal function

The remedy is contraindicated in people with pronounced problems in the functioning of the kidneys. If the concomitant diseases of the organ are not so pronounced, Next Uno Express can be used, but carefully.

With abnormal liver function

In the presence of severe pathologies associated with the liver, Next Uno Express should not be used.

Drug interactions

The combination of ibuprofen with anticoagulants may help to increase the influence of the latter. The simultaneous action of glucocorticosteroids and ibuprofen on the human body increases the likelihood of various complications associated with the work of the gastrointestinal tract. The combination of Amlodipine with ibuprofen can somewhat reduce the pharmacological properties of the latter.
The concentration in the blood of the active substance may decrease with its simultaneous use with acetylsalicylic acid, and in the case of administration with Baclofen, the toxic effect of ibuprofen on the body may increase.
Simultaneous use with lithium carbonate leads to an increase in the level of the latter in the blood. When combined with magnesium hydroxide, the ability of the body to break down ibuprofen increases.

Terms and conditions of storage

It is recommended to store the medicine in a dark place to which children do not have access, at a temperature not exceeding 25 ° C. Shelf life is 2 years.

Reviews

Oleg, 28 years old
“As an analgesic, it is an effective drug. Although nothing special about it. In its action, it resembles the same Paracetamol and Ibuprofen. The poison is still that, but you can quickly stop the sharp pain. ”
Christina, 25 years old
“Now I drink it during menstruation. In the first days, when menstruation begins, there is severe pain in the lower abdomen. On the third day, it subsides. Therefore, I take this painkiller and take it in such cases. It helps with a bang and at the same time the price is normal. "
Mikhail, 30 years old
“I had a bad toothache, I could not even open my mouth normally to eat. I had to go to the ambulance at night. There and advised such a medicine. It soothed the pain well. I would like to know, maybe there is the same remedy, but only in tablets. ”

Terms of sell

You don't need a prescription to buy Next Uno Express.