Diclofenac injections 25mg/ml 3ml #5

Instruction for Diclofenac injections

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pharmachologic effect

The active ingredient of the drug diclofenac injections is a non-steroidal anti-inflammatory drug (NSAID), which has pronounced analgesic, antipyretic and anti-inflammatory properties. Nonselective inhibitor of cyclooxygenase 1 and type 2 (COX-1 and COX-2). Violates the metabolism of arachidonic acid and the synthesis of prostaglandins, which are the main link in the development of inflammation. In rheumatic diseases, the drug significantly reduces pain, morning stiffness, swelling of the joints, which improves the functional state of the joint. With injuries in the postoperative period, diclofenac injections reduces pain and inflammatory edema.

Indications for use

Inflammatory and degenerative forms of rheumatic diseases: - rheumatoid arthritis; - ankylosing spondylitis; - osteoarthritis; - spondyloarthritis. Pain syndromes of the spine. Rheumatic diseases of extra-articular soft tissue. Acute gout attack. Post-traumatic and postoperative pain, accompanied by inflammation. Severe migraine attacks. The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, does not affect the progression of the disease.

Contraindications

Hypersensitivity to diclofenac injections (including other NSAIDs) and other components of the drug. • Complete or incomplete combination of bronchial asthma, recurrent nasal polyposis or paranasal sinuses and intolerance to acetylsalicylic acid and other NSAIDs (including in history). • Exacerbation of gastric ulcer and duodenal ulcer, ulcerative bleeding of the gastrointestinal tract, perforation. • Severe hepatic, renal (creatinine clearance (CK) less than 30 ml / min) and heart failure. • Conditions involving the risk of bleeding (for example, cerebrovascular bleeding, etc.), hemophilia, and other bleeding disorders. • Confirmed hyperkalemia. • Early postoperative period after coronary artery bypass surgery. • Inflammatory bowel disease (Crohn's disease, ulcerative colitis) in the acute phase. • Active liver disease. • Pregnancy III trimester, breastfeeding period. • Children's age up to 18 years.

Dosage and administration

Diclofenac, a solution for intramuscular injections, should be administered individually, in the minimum effective dose for the shortest possible period of time. Diclofenac injections in ampoules is particularly suitable for the initial treatment of inflammatory and degenerative rheumatic diseases, as well as for pain due to inflammation of non-rheumatic origin. The drug is administered by deep injection into the gluteus maximus. Do not use diclofenac injections for more than 2 days in a row. If necessary, treatment can be continued with diclofenac tablets or rectal suppositories. When conducting intramuscular injection in order to avoid damage to the nerve or other tissues, it is recommended to adhere to the following rules. The drug should be administered deep intramuscularly in the upper outer quadrant of the gluteal region. The dose is usually 75 mg (contents of 1 ampoule) 1 time per day. In severe cases, as an exception, 2 injections of 75 mg each can be given, with an interval of at least 12 hours (the second injection should be carried out in the opposite gluteal region). Alternatively, a single injection of the drug per day (75 mg) can be combined with taking other dosage forms of diclofenac (tablets, rectal suppositories), while the total daily dose should not exceed 150 mg. In migraine attacks, the best result is achieved if injections diclofenac is administered as early as possible after the onset of the attack, intramuscularly at a dose of 75 mg (1 ampoule), followed by the use of suppositories at a dose of up to 100 mg on the same day, if required. The total daily dose should not exceed 175 mg on the first day, then no more than 150 mg. The solution should be clear. Do not use a solution with a crystalline or other precipitate. The drug ampule should be used only once. The solution should be injected immediately after opening the ampoule. After a single application, the residues of diclofenac solution for injections unused for treatment are no longer used. Do not mix the solution of diclofenac, contained in ampoules, with solutions of other drugs for injection. Diclofenac, solution for intramuscular injections, should not be used in children and adolescents under 18 years of age due to the difficulty of dosing the drug; if necessary, treatment in this category of patients diclofenac can be administered in tablets or suppositories.

Release form

Solution for intramuscular administration of 25 mg / ml. On 3 ml in ampoules with a capacity of 5 ml of colorless neutral glass with a color ring of a break or with a color point and a notch or a ring of a break, a color point and a notch. One, two or three color rings and / or two-dimensional bar code, and / or alphanumeric coding with or without additional color rings, two-dimensional bar code, alphanumeric coding can be additionally applied to the ampoules. On 5 ampoules in a blister strip packaging from a film of polyvinyl chloride and aluminum foil lacquered or polymer film or without foil and without film. Or 5 ampoules are placed in a pre-made form (tray) of cardboard with cells for laying ampoules. One or two blister packs or cardboard trays together with instructions for use and scarifier or ampuln knife, or without scarifier and ampuln knife are placed in the carton (pack).

Terms of sell

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