Dexalgin injections 25mg/ml 2ml #10

Dexalgin injections instruction

You can buy Dexalgin injections here

Technical information

As you can learn from the instructions for use for injections, "Dexalgin" is an effective drug based on dexketoprene. This connection is quite strong, so the sale of the product prepared with its use from pharmaceutical points of sale is allowed strictly upon presentation by the buyer of a prescription made according to all the rules. "Dexalgin" is made in the form of a solution intended for injection into a vein and muscle tissue. The drug is packaged in ampoules, each contains 25 mg of the active ingredient. One pack contains from one ampoule to ten. The exact quantity is necessarily mentioned by the manufacturer on the outside of the cardboard box.
As stated in the instructions for use for injections, "Dexalgin" is a completely transparent liquid substance that does not have color. If you smell the open ampoule, you can feel a specific alcohol smell. The liquid must be homogeneous, solid particles are not allowed, there should be no sediment and flakes. In the presence of such ingredients, it is recommended to dispose of the contents of the capsule. As additional substances, dexketoprofen is accompanied by sodium compounds, ethanol and purified water, prepared industrially especially for injective administration.

Pharmacology

As you can learn from the accompanying "Dexalgin" injections instructions for use, the injections of this drug are a non-hormonal anti-inflammatory agent. Non-steroid drug has analgesic qualities, is able to arrest the activity of the inflammatory focus, lowers fever at the local level. The active component inhibits the activity of the first and second type of COX, which affects the severity of biochemical reactions involving prostaglandins. The analgesic effect on average is fixed half an hour after the injective injection. Its duration reaches 4-8 hours if the patient received 50 mg of the drug.
Allowed to include injections "Dexalgin" in a multi-component therapeutic course. You can combine the reception of this tool with opioid painkillers. It is noted that this combination reduces the patient's need for opioid substances by an average of 30-45%.

Pharmacokinetics

Soon after the introduction of the agent into the muscle tissue, the maximum concentration of the active ingredient in the blood plasma is observed. With the introduction of Dexalgin injections, the duration of achieving this concentration is estimated at 20 minutes, although some deviations in the range of 10-45 minutes are possible. Kinetic parameters when using 25-50 mg of the drug vary linearly, depending on how much medicine the patient received. It does not matter whether the substance was obtained in a vein or muscle. Kinetic parameters for single use and reuse do not differ. Scientists say with confidence that the cumulative effect of the tool is not inherent.
There is an increased ability of the active ingredient of the drug "Dexalgin" injections to enter into communication with whey proteins. The level of binding is estimated at an average of 95%. The volume of distribution is estimated to be less than 0.25 l / kg. The duration of the half distribution reaches a third of an hour.
As can be learned from the accompanying instructions for Dexalgin injections, the active ingredient is eliminated mainly by the urine kidneys. The main reaction is conjugation. The process occurs with the participation of glucuronic acid. The half-life is estimated at 1-2.7 hours.

Special cases

Studies have been conducted to determine the characteristics of the introduction of elderly people injections "Dexalgin". In the instructions, the manufacturer indicates that for such a group of patients, in general, lengthening of the half-life stage is characteristic. This is observed when a single use of anti-inflammatory composition, and with repeated, equally applies to the introduction of both a vein and muscle tissue. Duration increases by an average of 48%. At the same time there are reduced indicators of the total clearance of the funds.

When recommended?

It is recommended to use this remedy in case of pain. Injections of Dexalgin intramuscularly are well suited to weaken it. Instructions for use advises to use the drug for pain of a different etiology. You can use the solution, if the pain is associated with the transferred operation, accompanies the formation of metastases in the supporting system, due to injury received earlier. You can apply "Dexalgin" on the background of toothache and renal colic, with ischialgia and neuralgia. The tool shows a pronounced effect on patients with radiculitis and persons whose pain is associated with algomenorrhea.
It is allowed to use the drug for symptomatic treatment - the instructions for use accompanying “Dexalgin” injections tell about it. Intramuscularly injections of the drug are done if an inflammatory focus has been identified, including complicated degenerative processes. You can use the composition in the case of acute disease, and during its development by the type of chronicle. "Dexalgin" helps with diseases affecting the metabolism. It is used as a drug to alleviate the symptoms, if the pathology has covered the musculoskeletal system. It must be remembered that with such diagnoses the drug is not a means to cure the patient. For arthritis, arthritis, osteochondrosis, and similar diseases, it is used only to alleviate the manifestations of pathology.

Dosing rules

The drug “Dexalgin” intended for stabbing adults is usually given in the amount of 50 mg. Pauses between injections vary within 8-12 hours. If the pain syndrome is strong or the features of the patient's body are such that the analgesic effect weakens earlier, you can use the tool with six-hour pauses. The maximum daily dose is 150 mg.
Older people, as well as patients who have impaired kidney and liver function, are initially prescribed a quantity lower than the standard. During the day you can not use more than 50 mg.
As specified in the instructions describing the rules and indications for use of Dexalgin, injections can be used with a short therapeutic program. The tool is designed for short-term use - no more than two days in a row. It is designed for use in case the patient is in acute pain. To continue the treatment, it is recommended to transfer the person to oral painkillers.

How to prepare and apply?

To injection "Dexalgin" gave a good effect, you need to use the composition correctly. One vial contains 2 ml of liquid, including the main ingredient and additional components. If it is necessary to introduce a substance into the muscle tissue, the drug should be injected as deeply and slowly as possible. To do this, use syringes with long needles. If it is necessary to apply the agent intravenously, the duration of one procedure is 15 seconds or more. Do not inject the substance quickly into the vein or into the muscles.
To dilute the contents of the ampoule it is necessary to use Ringer's solution or glucose, physiological. At 2 ml of the drug take 30-100 ml of this liquid. The solution must be prepared under strictly aseptic conditions. Be sure to protect against sun exposure and the effects of ultraviolet rays. As soon as it is ready, the product must be completely transparent. The presence of foreign inclusions is unacceptable. The prepared substance should be slowly infused into the vein. The duration of the procedure reaches half an hour, but can not be less than 10 minutes.

Undesirable aspects: what to be ready for?

The manual describes all possible side effects of injections. "Dexalgin" injections, as studies have shown, can trigger the development of anemia, neutro-, thrombocytopenia, sleep disorders, paresthesia. Some have a pain and dizziness. There is a risk of temporary deterioration of vision and hearing, decrease in pressure, redness of the skin. Some patients note a sensation of heat, a violation of the frequency and speed of the heartbeat. Possible increase in pressure, swelling, thrombophlebitis of blood vessels close to the skin. Observations have shown that occasionally patients develop bronchial spasm, bradypnea, dyspnea.
As can be seen from the reviews of Dexalgin, injections in some were the cause of nausea, vomiting, stool disorders, polyuria. There is a possibility of dyspepsia, abdominal pain and disorders of the liver, pancreas. Possible failures of the monthly female cyclicity, the functionality of the male prostate gland. There is a risk of muscle spasm, deterioration of joint mobility. Skin reactions may develop, including rash, dermatitis, increased sensitivity to light and activation of the sweat glands. Allergies, metabolic disorders, ketone-, proteinuria are possible. The majority of patients who received injections, noted the pain of their injection area. A bruise or inflammation, local discomfort may form in this area. Some of them had a backache, a feverish state developed, their face swelled. There is a danger of anaphylactic shock, non-bacterial meningitis. Meningitis is more often observed on the background of SLE or combined pathologies affecting connective tissue. There is a possibility of a violation of the hematopoietic function.

Is it possible or not?

As can be inferred from the instructions, in which the contraindications and indications of Dexalgin injections are described in detail, the injections of this drug are prohibited for persons suffering from intestinal, gastric ulcers. The remedy is not used if there is a mention of bleeding in the gastrointestinal tract in the history of the disease, if the patient has any active bleeding at the moment or such is suspected inside the skull. You can not use the drug if a person has been prescribed drugs that worsen blood coagulation. The drug is not administered on the background of Crohn's disease, colitis and other gastrointestinal pathologies. Anti-inflammatory anesthetics should not be used if the kidneys and liver work with a variety of disorders, the creatinine clearance per minute is estimated at less than 50 ml, and according to the Child-Pugh rating system, the condition is 10-15 units.
“Dexalgin” produced in ampoules is not suitable for alleviating the condition of persons with asthma. This applies not only to those who have the disease is active at the moment, but also in the case of mentioning it in the history of the disease in the past. You can not use painkillers in case of insufficiency of the heart in severe form, as well as for the treatment of minors. "Dexalgin" is not suitable for persons whose organisms have coagulation problems. The drug is not used for diathesis, as well as pain accompanying coronary artery bypass surgery. It is forbidden to inject a remedy with an increased susceptibility of the active ingredient to the patient, as well as auxiliary components used by the manufacturer of the remedy.
"Dexalgin" injections can not be administered intrathecal, into the membranes, epidurally. Restrictions due to the presence of ethanol in the composition of the tool.

Safety first

As can be inferred from reviews of Dexalgin, injections of this drug are sometimes prescribed to persons who have previously suffered from allergic reactions. People who have been prescribed a remedy for such a medical history recognize that doctors treated them most carefully, prescribed frequent methods and checks of their condition, and also explained how to give first aid to themselves if undesirable effects develop. “Dexalgin” is used with caution if problems of the hematopoietic system, SLE or combined pathologies affecting connective fibers are identified. If it is necessary to combine non-hormonal with other medications, it is necessary to especially carefully evaluate the patient's condition. Accuracy requires a tendency to hypovolemia, ischemia, advanced age.
In the period of childbearing, lactation, the considered anti-inflammatory is strictly prohibited. If hepatic impairment is estimated at 10-15 units in the Child-Pugh system, the drug is not used, with less pronounced problems, it can be prescribed in a lower dosage. Per day can not use more than 50 mg. With creatinine clearance of more than 50 ml / min and the presence of renal impairment, treatment with Dexalgin begins with a minimum dosage. On the day the patient can enter no more than 50 mg of the drug.

Nuances of application

As you can learn from the instructions explaining why Dexalgin injections are especially effective, the drug is prescribed for inflammatory foci in the body, severe pain syndrome. In such conditions, the agent is used only in adults. Children "Dexalgin" is strictly contraindicated. If the patient is more than 65 years old, the drug can be used, but with extreme care. People with digestive problems or abnormalities of the gastrointestinal tract, diseases of this organ, which were previously transferred, require a special relationship. It is necessary to regularly check the performance of organs. There is a possibility of bleeding or the formation of a lesion. This development requires an urgent cancellation of the anti-inflammatory solution.
Any non-hormonal anti-inflammatory drugs are drugs that are associated with an increased risk of inhibition of the formation of platelets. More prolonged bleeding is possible as prostaglandin generation becomes slower. Given this information, the manufacturer of Dexalgin organized tests designed to clarify the features of the simultaneous use of this drug and low molecular weight heparin after surgery. No noticeable effects on coagulation parameters were recorded. If you intend to use "Dexalgin" and medications that can correct blood clotting, the manufacturer calls to be especially careful and regularly check the patient's condition.
Reliability of treatment is the key to a good result.
Any nonsteroidal anti-inflammatory type can cause an increase in serum nitrogen concentration, creatinine concentration. Like other inhibitors of the generation of prostaglandins, the drug in question may adversely affect the urinary organs. As a result, there is the likelihood of nephritis, necrosis, kidney failure.
According to the reviews of doctors about Dexalgin, injections in some patients were the cause of the growth of a number of parameters reflecting the work of the liver. In some patients, the parameters of ALT, AST were significantly increased in the blood plasma. It is especially important to regularly check the performance of the body if Dexalgin is assigned to a person in old age. If the parameters are much higher than normal, you should cancel this drug.
"Dexalgin" injections can hide the symptoms of infection. If there is an assumption of infection by bacteria, if the state of health of the patient receiving the injection becomes worse, the person should immediately inform the attending doctor.

Opinions of patients

You can find a lot of reviews about injections Dexalgin. Injections for osteochondrosis, arthritis and arthrosis were recommended by doctors to many patients who applied for qualified help. According to people who received the drug, on the background of injections the pain subsided, the state during the period of exacerbation of the pathology became easier. At the same time, people receiving injections admit that they have often experienced side effects. Most of them noted that they were aching and dizzy, their stools were disturbed, and their stomach was disturbed by discomfort.
As can be inferred from reviews, Dexalgin injections (a photo of the drug is in the article) are widely regarded as quite painful. The drug itself is quite expensive, so not every citizen of our country can afford it. Many people whom the doctor recommended “Dexalgin” recognized that they had to ask the doctor to advise a more affordable analogue — fortunately, such people are present in quite a large number on the pharmaceutical market.

Reliable and tested

Numerous reviews allow us to say with certainty: non-hormonal anti-inflammatory in general, and "Dexalgin" injections in particular, is a rather demanded class of pharmaceutical products. The drugs are intended to be implemented strictly according to the doctor’s prescription, but not all pharmacies treat this restriction very responsibly. Some buyers noted that they managed to purchase Dexalgin without a prescription. At the same time, the experience of using this remedy among those who engaged in self-treatment is more negative compared to those who received the medication under the supervision of a specialist. The manufacturer recommends avoiding the independent use of this potent agent, since it is associated with an unjustified risk of multiple side effects.

Terms of sell

You don't need a prescription to buy Dexalgin injections.