Ursofalk caps 250mg #100

Ursofalk instruction for use

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Pharmacological action

Ursofalk according to the instructions has a choleretic, destroying cholesterol stones, cholesterol-lowering effect.
The drug protects the membranes of liver cells and biliary tract from damage by toxic bile acids, and also prevents the proliferation of connective tissue in the liver in case of damage to hepatocytes.
Ursofalk contains urodeoxycholic acid. It, as it were, delimits the smallest structures of bile acids with a structural shell - forms the so-called mixed micelles. Urodeoxycholic acid also interacts with lipophilic membrane structures, making them resistant to damage. Thus, it implements a cytoprotective (protective) effect.
A decrease in the content of cholesterol in bile is realized by reducing its reabsorption in the intestine, suppressing the formation in the liver and reducing excretion into bile. In bile, the content of bile acids increases, due to which cholesterol gallstones dissolve, and new ones are not formed.
Like its counterparts, Ursofalk enhances the secretion of the stomach and pancreas.
The drug has an immunological effect - it affects the content of different classes of immune cells in the body, and at the liver level it slows down the development of fibrosis in patients with cystic fibrosis, primary biliary cirrhosis, alcoholic liver damage, and reduces the likelihood of esophageal varicose veins. There are positive reviews about Ursofalk when it is included in the program for the treatment of malignant diseases of the colon (cancer), it is able to delay the growth of tumor cells.

Release form

Ursofalk is produced in capsules of 250 mg and in suspension (250 ml vials, the content of urodeoxycholic acid is 250 mg / 5 ml).

Indications for use

The drug is prescribed for the treatment of primary biliary cirrhosis, subject to a compensated condition, biliary reflux gastritis, to dissolve cholesterol stones in the gallbladder and in the case of cholestasis with parenteral nutrition, in the complex treatment of cystic fibrosis, biliary dyskinesia. It is also recommended to prevent the development of colon cancer in high-risk groups for this disease.
There is no age limit. Thus, the use of Ursofalk as a means of reducing the level of indirect bilirubin in the blood is possible in newborns with conjugated hyperbilirubinemia (jaundice).

Contraindications

According to the instructions, Ursofalk is not used for individual intolerance, in the case of X-ray-positive gallstones (they contain a lot of calcium), for inflammatory diseases of the biliary tract and intestines, decompensated cirrhosis of the liver, non-functioning gallbladder, for disorders in the functioning of the kidneys, liver or pancreas.

Instructions for use

The drug is taken once a day (at night) inside. The capsule is swallowed without opening the shell, washed down with water. The average daily dose of Ursofalk is calculated for the patient's body weight and is 10 mg / kg / day. If the dosage exceeds the average, you can divide the daily dose into 2 - 3 doses. Ursofalk suspension is recommended for the treatment of children under 3 years of age and patients weighing less than 34 kg, as well as for swallowing difficulties. It is recommended to take the drug for a long time - from several months to 2 years, without interruptions in treatment.
To dissolve stones in the gallbladder, before starting treatment, you should make sure that they are cholesterol (they are not visible on the roentgenogram), no more than 20 mm in size, fill the gallbladder no more than half, while maintaining the patency of the biliary tract. Like its analogs, Ursofalk is not recommended to be used simultaneously with drugs that increase the cholesterol content in bile (clofibrate, estrogens, etc.). Antacids impair drug absorption.
In the case of cholelithiasis, the duration of dissolution of stones is from 6 to 24 months, but if no positive dynamics is noted after 12 months from the beginning of the intake, Ursofalk can be canceled, since further treatment is inappropriate for them. To monitor the effectiveness of treatment, the liver and bile ducts should be examined every six months using ultrasound and X-ray.
With biliary reflux gastritis and reflux esophagitis, the course of administration lasts an average of 10-14 days.
With cystic fibrosis, the daily dose of Ursofalk reaches 20-30 mg / kg / day, with primary biliary cirrhosis up to 15-20 mg / kg / day.

Side effects

According to reviews, Ursofalk sometimes causes allergic reactions, diarrhea, dyspepsia, calcification of gallstones.

Operating principle

"Ursofalk" is a group of hepatoprotectors, as this drug has a positive effect on the condition of the liver and biliary tract. It has properties such as:
    protect hepatocytes from harmful effects;
    stimulate the formation, as well as the secretion of bile;
    interfere with the synthesis of cholesterol in liver cells, as well as reduce its absorption in the intestine (the result will be a decrease in blood cholesterol levels);
    increase the solubility of cholesterol in the biliary tract, thereby dissolving cholesterol stones;
    reduce the lithogenicity of bile (a tendency to form stones);
    increase the concentration of bile acids in bile;
    enhance the secretion of enzymes in the stomach and pancreas;
    increase lipase activity;
    reduce the saturation of bile with cholesterol;
    activate immune responses in liver cells.
Studies have also confirmed the positive effect of the drug in patients with cystic fibrosis. In case of damage to the hepatobiliary system after courses of "Ursofalk", the lesions appeared less often, and if the treatment was started in the early stages, the reverse development of changes was also observed.

Terms of sell

You can buy Ursofalk without a prescription.