Nifural caps 200mg #16

Instruction for Nifural

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Composition and form of release

The drug is available in the form of capsules and suspensions for the preparation of solutions. Nifural in capsules looks like small (size 2 in a dosage of 200 mg and No. 0 in 100 mg) cylindrical gelatin shells, consisting of a body and a lid. They do not smell and have a uniform yellow color. Inside is a fine powder mixed with crystalline granules. Tablets are packaged in plastic packages of 7, 8, 10 or 14 units. A cardboard box may contain 1, 2 or 4 of these blisters. The composition of one capsule includes such components:
    the active substance nifuroxazide in an amount of 100 or 200 mg;
    MCC;
    corn starch;
    sucrose;
    magnesium stearate.
The protective shell of the tablet consists of titanium dioxide, iron oxide and gelatin. In addition to blisters with medicine, instructions must be contained in a cardboard package.

Pharmachologic effect

The active substance Nifural is a strong antiseptic, exhibiting its properties when it enters the human intestine. It has the ability to suppress the vital activity of such pathogenic organisms as Shigella, E. coli, Salmonella, cholera and other pathogenic vibrios, staphylococci, Campylobacter, as well as spore bacteria of the species Clostridium perfringens (pathogens of gas gangrene and food poisoning).
The drug acts on the cells of bacteria and other microorganisms, inhibiting protein synthesis and the production of pheromones that they need to maintain vital activity. In addition, its action contributes to the destruction of the protective membranes of pathogens, reduce the production of microbes toxins and other substances that poison the human body.
The use of Nifural does not lead to the emergence of drug-resistant strains of pathogenic bacteria. Cross-resistance formation with other antiseptic drugs is also not observed. However, there are pathogens that are naturally not very sensitive to the drug. These include: rod-shaped opportunistic bacteria Enterobacter cloacae, cytrobacters and Proteus indologenes. Klebsiella, Providence, Proteus mirabilis and Pseudomonas are completely resistant to nifuroxazide.
Of the characteristics of the effect of the drug, it can also be noted that it is practically not absorbed when passing through the digestive system and begins to show activity, only in the intestinal lumen. Its effectiveness is not affected by the acidity of the medium (pH) or the degree of resistance of pathogens to antibacterial agents.
This medication has no effect on the healthy microflora of the intestine and digestive tract. On the contrary, it helps to restore balance in it when infected with acute bacterial infections. In the fight against enterotropic viruses, Nifural helps to prevent the occurrence of bacterial superinfection.
    From the body, the drug is excreted by the intestines. About a fifth of it leaves the human body unchanged, the rest is converted into metabolic products.

Indications and Impact

The only indication for the use of Nifural is acute bacterial diarrhea. It should not be accompanied by high temperature, infection, intoxication and worsening of the general condition of the patient. The medication is able to have the following effects on the patient's body:
    astringent effect, due to which the elimination of loose stool occurs and dehydration stops;
    relieving pain and cramping in the abdomen, relieving discomfort and heartburn;
    preventing bloating of the intestinal walls and the accumulation of gases in them (flatulence);
    elimination of bad breath and belching, if they were caused by diarrhea;
    protection of the mucous membranes of the gastrointestinal tract from the penetration of toxic substances.
    Since the active substance of suspensions and tablets Nifural very quickly enters the intestines and has almost no effect on other systems of the body, doctors note the rapid appearance of effects from it. Its bactericidal properties complement this, preventing the recurrence of diarrhea and diarrhea.

Application rules

When taking any medicine, it is important to follow the instructions and dosage. This will help to achieve the greatest effect without undesirable consequences. Nifural is available in the form of capsules and suspensions, the method of use of which is different.
The tablets must be taken orally, that is, by mouth. Swallow the capsule whole with a little water. It is forbidden to remove the cap from the tablet, as well as to open, puncture, dissolve or otherwise damage its gelatin shell. A single dose of the drug is always 200 mg, whether it is one tablet or two 100 mg each. The amount taken by the patient per day depends on age and should be as follows:
    children under 6 years old - 3 times a day with breaks of 8 hours;
    up to 18 years - 3-4 doses per day every 6 or 8 hours;
    older than 18 years - 4 doses per day, interval of 6 hours.
    If the dosage prescribed by the doctor does not coincide with that indicated in the instructions, then priority is given to the doctor’s instructions. However, if the recommended amount of Nifural is ineffective, the patient is usually transferred to a stronger medication with a systemic effect, rather than increasing the dosage.

Side effects and contraindications

Among the side effects of Nifural, allergic reactions, such as rash, itching, urticaria, shortness of breath, are most often noted. The development of serious conditions is also possible, for example, anaphylactic shock and Quincke's edema may occur. If any of them appears, the drug should be stopped immediately. When taking the suspension, it is worth remembering that allergies can occur with a delay.
In people who do not suffer from individual intolerance to the components, undesirable reactions should not occur, but if you suspect them, you should also refuse the drug and consult a doctor. Among the contraindications to the drug can be noted:
    hypersensitivity to nifuroxazide or any auxiliary component of capsules or suspensions;
    impaired liver function;
    brain damage caused by diseases or traumatic brain injuries;
    lack of sucrose in the body.

Special instructions

When treating diarrhea and diarrhea, Nifural should simultaneously take a course of restoring water balance in the body. If you suspect a systemic bacterial infection that affects not only the intestines, but also other organs, you should consult a doctor to prescribe additional drugs or another drug.
After the start of treatment with Nifural, it is forbidden to drink alcoholic beverages and other products containing alcohol. This medication does not affect the consciousness and ability to control mechanisms, as well as perform any work that requires an increased concentration of attention.
During animal tests, no adverse effects of the drug on cubs of nursing mothers were observed. However, taking Nifural during lactation is not recommended without supervision by the attending physician. If the doctor’s permission has been obtained, breastfeeding can be continued during the course of therapy.
The drug is undesirable to use in combination with drugs that have a depressing effect on the nervous system. It is also not necessary to combine it with Disulfiram and other means that cause disulfiram-like reactions.

Patient Reviews

People suffering from diarrhea and diarrhea often used Nifural as an analogue to more expensive drugs. Of the advantages, its low price, high efficiency, safety and speed of action were noted, of the minuses that the medication can only be used with bacterial diarrhea without complications, and also its usefulness only against certain forms of bacteria, in some cases it is ineffective.
Lyudmila
I decided to try Nifural in capsules as a cheap analogue of Enterofuril for diarrhea. The medicine acts quickly, relieves symptoms, and then they do not return. She took it herself, also gave it to children (6 and 8 years old), none of us had any adverse reactions. Now I always keep stock in the first-aid kit, the expiration date allows.
Helena
Used this drug when my daughter caught diarrhea. At the pharmacy there were pills and syrup, I bought the first because they are cheaper. Improvements in the stool were noticeable the next day, but just in case, continued the course of treatment, as indicated in the instructions. The price is low, the effect is fast, the tablet is tasteless, so the child drinks Nifural without tears and vagaries. A good drug, I recommend to everyone who has similar problems.
Irina
I caught diarrhea in the summer, at first I thought that it was ordinary food poisoning, but activated carbon and other means did not help. The pharmacy advised Nifural. I drank three tablets in three days, by the evening of the first day it became a little easier, and in the morning the disease almost completely disappeared. Inexpensive and fairly effective medicine.

Terms of sell

A prescription is not required to buy Nifural.