Mirofuril caps 200mg #30

Mirofuril user manual

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Mirofuril is a broad-spectrum antimicrobial drug, intestinal antiseptic.

Release form and composition

Dosage form of the drug:
    capsules: hard gelatin capsules, capsule body and cap with a dosage of 100 mg (size No. 2) - yellow, a dosage of 200 mg (size No. 0) - white; the contents of the capsules are yellow powder, or yellow powder with small pieces of pressed mass, or pressed yellow powder, crumbling with light pressure (in blisters: dosage of 100 mg - 10 pcs., in a cardboard bundle 1, 2, 3 , 4 or 5 packs; dosage of 200 mg - 7, 8 or 10 pcs., In a cardboard bundle of 1, 2, 3, 4 or 5 packs);
Each pack also contains instructions for the use of Mirofuril.
1 capsule contains:
    active substance: nifuroxazide - 100 or 200 mg;
    auxiliary components: corn starch, sucrose, microcrystalline cellulose, magnesium stearate;
    shell: gelatin, titanium dioxide (E171); in addition, capsule dosage of 100 mg - iron oxide yellow.

Pharmacodynamics

Mirofuril is an antimicrobial drug that has a wide range of bacteriostatic effects. When used in high doses, it has a bactericidal effect. Its active substance, nifuroxazide, is a derivative of 5-nitrofuran. The antimicrobial activity of nifuroxazide is due to the presence of an NO2 group in its composition, which blocks the activity of dehydrogenase, inhibition of the respiratory chain, the tricarboxylic acid cycle, and a number of other biochemical processes, which leads to impaired protein synthesis in pathogenic bacteria.
Against the background of the use of the drug, the production of toxins by microorganisms decreases, the membranes of microbial cells are destroyed. Reception of nifuroxazide does not lead to the emergence of resistant strains or cross-resistance with other antibacterial agents. The therapeutic effect of nifuroxazide is not dependent on pH in the intestinal lumen and the susceptibility of microorganisms to antibiotics.
The following pathogenic intestinal bacteria exhibit high sensitivity to nifuroxazide: Staphylococcus speciales (spp.), Salmonella spp., Shigella spp., Campylobacter jejuni, Escherichia coli, Clostridium perfringens, Vibrions and Vibrio parahaemolyticus, Vibrioce.
Nifuroxazide shows weak activity against Enterobacter cloacae, Citrobacter spp., Proteus indologenes.
Nifuroxazide is resistant to Klebsiella spp., Providencia spp., Proteus mirabilis, Pseudomonas spp.
In acute diarrhea of ​​bacterial etiology, the drug helps to restore intestinal eubiosis. It prevents the development of bacterial superinfection when infected with enterotropic viruses.
Nifuroxazide does not affect the saprophytic flora and does not upset the balance of the normal intestinal flora.

Pharmacokinetics

After ingestion, nifuroxazide is almost not absorbed from the digestive tract and does not enter the systemic circulation. The antibacterial effect is realized exclusively in the intestinal lumen. It is completely excreted through the intestines (unchanged - 20%).

Indications for use

The use of Mirofuril is indicated for acute bacterial diarrhea that occurs without an increase in body temperature, deterioration in general condition and intoxication.

Contraindications

Absolute:
    sucrose and / or isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption syndrome;
    pregnancy;
    the period of the newborn (up to 1 month), prematurity (suspension for oral administration);
    children's age up to 3 years (capsules);
    hypersensitivity to the components of the drug.
The use of capsules during lactation is indicated only with a temporary cessation of breastfeeding.

Instructions for use: method and dosage

Capsules are taken orally.
The duration of the course of therapy should not exceed 7 days.
Recommended Dosage:
    adults and children over 6 years: 200 mg 4 times a day;
    children 3-6 years: 200 mg 3 times a day.
If after three days of treatment the patient's condition does not improve, it is necessary to consult a doctor.

Side effects

In some cases, the use of Mirofuril can cause nausea, vomiting, the development of allergic reactions in the form of a rash, urticaria, Quincke's edema or anaphylactic shock.
In addition, hypersensitivity reactions may occur (symptoms - shortness of breath, itching, rash), requiring immediate discontinuation of the drug.

Overdose

Symptoms of an overdose have not been established.
Treatment: immediate gastric lavage, the appointment of symptomatic therapy.

Special instructions

Treatment of diarrhea with Mirofuril must be accompanied by rehydration using an oral or intravenous method of therapy depending on the patient's condition and the intensity of diarrhea.
If side effects appear or worsen, consult a doctor.
The simultaneous use of alcohol or ethanol-containing medicines is contraindicated.
If bacterial diarrhea occurs with such signs of systemic damage as an increase in body temperature, deterioration in general condition, the presence of symptoms of infection or intoxication, you should consult a doctor to prescribe antibacterial drugs of a systemic effect.
It should be borne in mind that the content of ethanol (in terms of absolute alcohol) and sucrose in 2.5 ml of suspension is 0.019 g and 0.05 XE (bread unit), respectively, and in the maximum daily dose for adults (20 ml) - 0.152 g and 0.4 XE.

Influence on the ability to drive vehicles and complex mechanisms

Mirofuril capsules do not adversely affect the patient's ability to drive vehicles and mechanisms.
The effect of the suspension on psychomotor processes has not been studied, but drivers should consider the content of ethanol in its composition.

Pregnancy and lactation

The use of Mirofuril is contraindicated during the gestation period.
During lactation, the use of capsules is indicated only according to strict indications with the simultaneous cessation of breastfeeding.

Use in childhood

Mirofuril capsules are contraindicated for children under the age of 3 years.

Drug interaction

It is not recommended to use Mirofuril simultaneously with drugs that inhibit the function of the central nervous system.
When combined with ethanol, a disulfiram-like reaction can occur, which is characterized by the following symptoms: headache, nausea, vomiting, weakness, abdominal pain, tachycardia, blurred vision, cramps.
Patients who are on maintenance therapy with other drugs, you must first consult a doctor.

Terms and conditions of storage

Store in a dark place. Keep out of the reach of children.
Storage temperature: capsules - up to 25 ° C.
Shelf life: capsules - 3 years, suspension - 2 years.

Reviews

Reviews about Mirofuril are positive. Patients note the high effectiveness of the drug in the treatment of dysbiosis, rotavirus infection. The advantages include quick action, the presence of two dosage forms, which makes it possible to use in infants, as well as the pleasant taste of the suspension.

Terms of sell

You can buy Mirofuril without a prescription.