Mesacol tabs 400mg #50

Instruction for Mesacol

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Nonspecific ulcerative colitis is a chronic inflammatory process that occurs in the mucous membrane of the large intestine. Etiological factors are considered to be a genetic predisposition and the harmful effects of external agents. The medicine Mesacol is a unique anti-inflammatory drug and has a local effect. It prevents the further progression of the disease and promotes a speedy recovery. Thanks to the active component, repair mechanisms are activated, and ulcer defects heal. The medication is also effective for the treatment of Crohn's disease.

Pharmacological effect

The active substance of the drug Mesacol has antioxidant activity and protects cells from damage. By binding free radicals, mesalazine prevents the destruction of cell membranes by inhibiting the peroxidation of the lipid layer. It exhibits antibacterial properties. Pathogenic flora in the intestine, in particular Escherichia coli, is sensitive to its action. Mesalazine is a metabolic product of sulfasalazine. It is less toxic because it does not contain particles that cause the side effects of sulfasalazine. The anti-inflammatory effect is due to inhibition of the synthesis of inflammatory mediators. Mesalazine inhibits the lipoxygenase enzyme and interrupts the arachidonic acid cycle, resulting in the formation of prostaglandins and leukotrienes. In the absence of these biologically active substances, the development of inflammation is interrupted. The use of the drug many times reduces the risk of recurrence of Crohn's disease, since mesalazine acts on the pathological link of the disease.

Pharmacokinetics

Mesacol tablets are coated with a special film that protects them from the action of gastric juice. Thanks to her, they become soluble only in the intestinal lumen. The active component is released at a certain pH of the medium, mainly in the lower ileum and large intestine, which are the focus of the inflammatory process. Most of the substance is not absorbed into the systemic circulation, but remains in the intestinal lumen and exhibits a local anti-inflammatory effect. Mesalazine is metabolized in the liver and intestines, excreted in feces and during urination.

Composition

The drug Mesacol contains excipients and the active ingredient is mesalazine. The release form is presented in the form of tablets soluble in the intestinal lumen.

Indications for use

Indication for the use of Mesacol, in the first place, is ulcerative colitis. Taking the medicine is effective for varying degrees of severity of the disease. He is also prescribed as part of maintenance therapy during periods of remission. Another nosological unit that can be treated with a drug is Crohn's disease. The medication inhibits the further progression of the disease and prevents the occurrence of relapses.

Side effects and contraindications

Immunity reactions are represented by erythema, allergies, urticaria, Quincke's edema, fever. Hemodynamic changes in rare cases are manifested in the form of inhibition of all sprouts of hematopoiesis and the occurrence of pancytopenia. In adolescents, cases of benign intracranial hypertension have been described. Symptoms of a gastrointestinal tract malfunction include abdominal pain, diarrhea, flatulence and vomiting. In rare cases, pneumonia, bronchospasm, infiltrative damage to the lungs and alveolitis may develop. An increase in the level of transaminases and alkaline phosphatase, the development of cholestasis and hepatitis, which subsequently passes into liver failure, may indicate liver damage. In men, reversible oligospermia is observed. Cases of impaired renal function and the development of nephropathy with renal failure have been identified. The drug Mesacol is contraindicated in case of individual hypersensitivity to the active substance and other components of the medication. It is not prescribed if the patient has a severe pathology of the kidneys and liver. Reception is contraindicated in ulcerative lesions of the gastrointestinal tract.

Pregnancy and lactation

When using Mesacol during the period of bearing a child, there is a risk of teratogenic and embryotoxic effects, therefore, before prescribing the drug, pregnant women need to weigh the ratio of harm to benefit. Data on the penetration of substances into mother's milk are presented. Breastfeeding should be discontinued for the duration of therapy.

Instruction manual

Instructions for use of the drug Mesacol are provided as educational information. It is not recommended to self-medicate. Before you start taking the medicine, you must visit a doctor who, depending on the clinical picture and the patient’s body characteristics, develops a treatment regimen with the indicated dosages and duration of the course. Also, the doctor should identify possible contraindications and familiarize the patient with adverse reactions of the medication. With exacerbation of ulcerative colitis, the dosage is individually selected. The maximum concentration of the substance is 4 grams per day. For maintenance treatment in remission, the dosage is 2 grams per day. In the treatment of Crohn's disease, an individual dosage is also made, which should not exceed the mark of 4 grams daily. Children under 6 years of age in the treatment of ulcerative colitis and Crohn’s disease in the acute stage begin with a starting dosage of 30 mg / kg body weight. The maximum value should not exceed 75 mg / kg of weight. For maintenance therapy, the starting dosage is half as much. The daily dose is divided into several doses. The tablets must be swallowed without chewing and without violating their integrity, then drink plenty of fluids. They are taken an hour before a meal. For the effectiveness of therapy, you should follow the recommendations and not violate the regime.

Features of the reception

Reception of Mesacol is contraindicated in case of persistent impairment of kidney function, since the drug has pronounced nephrotoxicity. Before starting therapy, an examination is performed and indicators of the functioning of the urinary system are checked. When prescribing a medication to patients with high creatinine and the presence of proteins in the urine, it is necessary to carefully monitor their condition and periodically perform laboratory tests. If there are impaired renal function during therapy, the drug should be immediately withdrawn and emergency medical care should be provided to the patient. Cases of blood dyskrasia in patients are described, the symptoms of which are prolonged fever, anemia, hematoma, hemorrhage. Before and during treatment, it is necessary to monitor hemodynamic parameters. If dyskrasia occurs, the medication is canceled. For patients with hypersensitivity to mesalazine, therapy is carried out under the strict supervision of doctors. The appearance of fever, headache, rash and seizures indicates the development of a hypersensitivity reaction, the patient must be given medical attention. In this case, you should stop the substance from entering the body and accelerate its excretion. Effective use of hemodialysis. Mesalazine is able to cause an increase in the level of liver enzymes, it is used with caution in patients with liver pathology. Before prescribing a medication, a biochemical blood test is performed and the level of transaminases is checked. During therapy, the tests are periodically repeated. If a patient has ulcerative defects in the upper gastrointestinal tract, no medication is prescribed. Elderly patients can be prescribed a drug with an individual dosage selection while maintaining the functions of the urinary system. There is a likelihood of hypersensitivity reactions from the cardiovascular system. Not applicable to patients with myocarditis and pericarditis caused by the history of mesalazine. Patients with pulmonary pathology and bronchial asthma should be under the supervision of a doctor, since the side effects of the drug, in particular the development of bronchospasm, can aggravate their condition. The medication is not used for carbohydrate intolerance and lactase deficiency, since it contains carbohydrates as excipients. In pediatrics, children under six years of age are not prescribed due to the lack of official data on the safety and effectiveness of the drug for the child's body.

The effect of the drug on the ability to drive vehicles and complex mechanisms

Mesacol does not affect car driving skills and the ability to perform activities that require a high concentration of attention and a quick reaction. However, the occurrence of side effects, in particular dizziness. Care must be taken not to drive until the condition stabilizes.

Alcohol compatibility

There are a number of studies that indicate the harmful effects of alcohol intake in patients suffering from ulcerative colitis. Ethyl alcohol causes the development of oxidative processes, disrupts the barrier function of the intestine and leads to an exacerbation of the disease. The use of alcohol when using the drug Mesacol reduces the effectiveness of therapy. It is recommended to refrain from drinking alcohol.

Interaction with other medicines

In a combination of Mesacol with azathioprine, inhibition of all sprouts of hematopoiesis is observed. Therefore, it is necessary to monitor hemodynamic parameters. If persistent leukocytopenia is detected, the doctor should decide on the abolition of the medication or dose adjustment. The drug significantly inhibits the anticoagulant ability of warfarin, causes an increase in the sugar-lowering effect of sulfonylurea derivatives, and accumulates the toxic effect of methotrexate. Reduces the therapeutic effect of diuretics, in particular furosemide and spironolactone.

Overdose

The drug, following the instructions, does not cause undesirable manifestations. In case of an overdose, therapy is used to eliminate the symptoms and maintain the vital functions of the body. The specific antidote to the active component of the drug is not known. It is possible to use hemodialysis for therapeutic purposes to accelerate the elimination of substances and toxins from the body.

Reviews of patients and doctors

Doctors often include Mesacol in the complex treatment of ulcerative colitis at various stages of the disease. With a mild course, the drug promotes the healing of defects and prevents the development of new ones. In severe cases, taking the medication induces prolonged remission and stops the progression of the pathology. Patients noted a decrease in the intensity of symptoms shortly after the start of the drug. It is well tolerated with a properly selected dosage. It is often used in pediatrics for children over 6 years old and leads to positive results.

Storage rules

Storage of the drug is carried out at a temperature of not more than 25 degrees Celsius, out of the reach of children. Shelf life of Mesacol is 4 years from the production date shown on the package. At the end of this period, it is strictly forbidden to use the medicine, as it loses its healing properties and can cause harm to health.

Terms of sell

You can buy Mesacol without a prescription.