Pentaflucin 5gr #10

Instruction for Pentaflucin

You can buy Pentaflucin here

Release form and composition

Dosage form of Pentaflucin - granules for oral administration: a mixture of granules of a cylindrical, round or irregular shape, from yellow-green to white with a creamy tint and white (in bags of polymer-coated paper; in a cardboard bundle of 5 or 10 bags) .
The content of active substances in 1 sachet (5000 mg):
    Paracetamol - 500 mg;
    Ascorbic acid (vitamin C) - 200 mg;
    Calcium Gluconate - 200 mg;
    Diphenhydramine (diphenhydramine hydrochloride) - 20 mg;
    Rutin (rutoside) - 20 mg.
Auxiliary components: polyvinylpyrrolidone (povidone), sugar (sucrose), soluble saccharin (sodium saccharinate), citric acid.

Indications for use

Pentaflucin is recommended for use in adult patients for the treatment of the following symptoms of acute respiratory infections (acute respiratory infections) and acute respiratory viral infections (acute respiratory viral infections):
    Heat;
    Chills, body aches;
    Headache and muscle pain;
    Nasal congestion.
The drug is also used to increase the nonspecific resistance of the body to infection.

Contraindications

    Severe renal and / or liver failure;
    Blood diseases with a tendency to bleeding and hemorrhage;
    Hereditary deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD);
    Hyperoxaluria, nephrourolithiasis (calcium), nephrolithiasis;
    Thrombophilia (tendency to thrombosis);
    Sucrose-isomaltose deficiency, glucose-galactose malabsorption, congenital fructose intolerance;
    The period of pregnancy of breastfeeding (lactation);
    Children and adolescents under 18 years of age (there are no data from clinical studies);
    Hypersensitivity to any of the components of Pentaflucin.
Take the drug with caution in constitutional hyperbilirubinemia (Gilbert syndrome).
If it is necessary to use the drug during lactation, it is necessary to interrupt breastfeeding for the entire duration of therapy.

Dosage and administration

Granules are taken orally, dissolving the contents of 1 sachet in 0.5 cups of hot boiled water.
Recommended dosing regimen: 1 sachet 3-4 times a day, course of therapy - 3-5 days.
Only freshly prepared solution should be taken, it should be shaken before use, the presence of slight sediment / suspension is allowed.

Side effects of Pentaflucin

Subject to the recommended dosage regimen in rare cases, against the background of the action of the active components of Pentaflucin, the following side effects are possible:
    The complex of active components: skin allergic reactions, constipation, nausea, vomiting;
    Paracetamol: changes in the picture of peripheral blood (leukopenia, thrombocytopenia, agranulocytosis), nephrotoxic and hepatotoxic effects (prolonged use in high doses);
    Diphenhydramine: impaired coordination of movements and speed of psychomotor reactions, drowsiness, insomnia, irritability, euphoria, dizziness, tremor;
    Rutoside: flushing, diarrhea.
In case of observation of any adverse reactions, their aggravation or the manifestation of other effects not previously noted, you should immediately inform your doctor.
Symptoms of Pentaflucin overdose are: stomach pain, nausea, vomiting; after a few days, signs of liver damage are diagnosed, in some cases severe liver failure, encephalopathy and coma may develop.
To treat the condition, the patient at home should rinse the stomach, take adsorbents (activated charcoal) and consult a doctor immediately. Symptomatic therapy is further recommended (injections of acetylcysteine ​​and methionine).

Special instructions for Pentaflucin

It is not recommended to combine Pentaflucin with alcohol to avoid toxic liver damage.
In the process of therapy, caution should be exercised when driving vehicles and engaging in other potentially dangerous activities, which require the speed of psychomotor reactions and increased concentration of attention.
Patients with diabetes should be aware that the drug contains sugar, in 1 sachet - 0.33 XE.

Drug interaction

The presence in the preparation of active substances of a wide spectrum of pharmacological activity determines the possible drug interaction of Pentaflucin with other drugs / substances.
Paracetamol:
    Uricosuric drugs - reduces their effectiveness;
    Anticoagulants - reduces the synthesis of procoagulant factors in the liver (the use of paracetamol additionally in high doses increases the effect);
    Inducers of microsomal oxidation in the liver (tricyclic antidepressants, barbiturates, rifampicin, phenytoin, phenylbutazone), hepatotoxic substances / drugs, ethanol - increase the production of hydroxylated active metabolites, making it possible to develop severe intoxications even with a slight overdose of paracetamol;
    Barbiturates (in case of prolonged use) - reduce the effectiveness of paracetamol;
    Ethanol - contributes to the development of acute pancreatitis;
    Nonsteroidal anti-inflammatory drugs (NSAIDs) - with prolonged joint use, the risk of developing analgesic nephropathy, renal papillary necrosis, terminal stage of chronic renal failure increases;
    Diflunisal - increases the likelihood of developing hepatotoxicity due to a 50% increase in the plasma concentration of paracetamol;
    Myelotoxic drugs / drugs - increase the manifestations of hematotoxicity.
Diphenhydramine (diphenhydramine hydrochloride):
    Drugs that depress the central nervous system (central nervous system) and ethanol - diphenhydramine hydrochloride potentiate their action;
    Inhibitors of MAO (monoamine oxidase) - enhance its anticholinergic effect.
Ascorbic acid (Vitamin C):
    Benzylpenicillin and tetracyclines - their concentration in the blood rises;
    Ethinyl estradiol, including one that is part of oral contraceptives - at a dose of 1000 mg per day, vitamin C increases its bioavailability;
    Heparin and indirect anticoagulants - their effectiveness decreases;
    Iron preparations - their absorption in the stomach improves, ferric iron is converted to ferrous;
    Deferoxamine - iron excretion may be enhanced;
    Acetylsalicylic acid - its excretion in urine decreases and excretion of vitamin C increases, absorption of ascorbic acid decreases by 30%;
    Short-acting salicylates and sulfonamides - the excretion of acids by the kidneys slows down, the excretion of drugs with an alkaline reaction (including alkaloids) increases, the concentration of oral contraceptives in the blood decreases, the risk of crystalluria develops;
    Isoprenaline - the chronotropic effect is reduced;
    Barbiturates and primidone - increase urinary excretion of ascorbic acid.
Calcium Gluconate:
    Quinidine - probably increasing its toxicity and slowing down the intraventricular conduction of the heart;
    Tetracycline antibiotics: form insoluble complexes with calcium gluconate, which reduces the antibacterial effect;
    Tetracyclines, digoxin, oral iron preparations - absorption is reduced (the interval between their doses should be observed for at least 2 hours);
    Thiazide diuretics - can enhance hypercalcemia and reduce the effect of calcitonin with hypercalcemia;
    Phenytoin - its bioavailability decreases;
    Carbonates, salicylates, sulfates are pharmaceutically incompatible with calcium gluconate, since they form insoluble or sparingly soluble calcium salts;
    Slow calcium channel blockers - the therapeutic effect is reduced.
Interaction of the active components of Pentaflucin: ascorbic acid enhances the pharmacological effect of rutin (rutoside).
Acetylsalicylic acid, fresh juices, alkaline drink, oral contraceptives - reduce the absorption and absorption of the drug.

Terms and conditions of storage

Store in a dry, dark place at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Shelf life is 2 years.

Terms of sell

You can buy Pentaflucin without a prescription.