Otrivin Complex spray 0.6mg/ml + 0.5mg/ml 10ml

Otrivin Complex instruction

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Otrivin Complex - a combined vasoconstrictor drug for topical use in otolaryngology, with decongestant effectiveness.

Release form and composition

Dosage form of Otrivin Complex - nasal spray: a clear liquid without color or slightly colored, almost odorless (10 ml in a bottle, 1 bottle in a cardboard box).
Composition per 1 ml of solution:
    active substances: ipratropium bromide monohydrate - 0.6 mg; xylometazoline hydrochloride - 0.5 mg;
    auxiliary components: glycerol, disodium edetate dihydrate, concentrated hydrochloric acid, sodium hydroxide, water.

Pharmacodynamics

Otrivin Complex is a combined drug, the effect of which is due to the properties of its constituent components:
    xylometazoline is a local vasoconstrictor (decongestant). It has an alpha-adrenomimetic effect. Relieves edema and hyperemia of the mucous membrane of the nasopharynx due to narrowing of blood vessels. Eliminates congestion and facilitates nasal breathing;
    ipratropium bromide is an anticholinergic substance. Reduces nasal secretion due to competitive inhibition of cholinergic receptors located in the epithelium of the nasal cavity.
When using the drug in therapeutic doses, it does not cause irritation and hyperemia of the nasal mucosa. The therapeutic effect is manifested after 5-10 minutes and lasts up to 8 hours.

Pharmacokinetics

Absorption of the active substances of the drug with its local use is not significant.

Indications for use

    swelling and hyperemia of the nasal cavity (for symptomatic treatment);
    acute allergic rhinitis;
    rhinitis with nasal congestion in acute respiratory infections;
    hay fever;
    sinusitis.

Contraindications

Absolute contraindications:
    glaucoma;
    atrophic rhinitis;
    surgical operations on the membranes of the brain (in history);
    pregnancy (I trimester);
    age up to 18 years (due to the high content of the active substance Otrivin is not prescribed for children);
    increased sensitivity to the components of the drug, as well as to atropine and similar compounds (hyoscyamine, scopolamine).
Relative contraindications, in the presence of which a doctor's consultation is required before using the drug:
    hyperthyroidism;
    diabetes;
    pheochromocytoma;
    angina pectoris III - IV functional class;
    prostatic hyperplasia;
    bladder neck obstruction;
    cystic fibrosis;
    pregnancy (II and III trimester);
    lactation (breastfeeding);
    predisposition to nosebleeds, dizziness, skeletal muscle tremors, arrhythmias, sleep disturbances, high blood pressure (BP), paralytic bowel obstruction.

Instructions for use Otrivin Complex: method and dosage

Otrivin Complex is used intranasally.
Recommended dosage for adults: 1 injection in each nasal passage 3 times a day.
The duration of therapy should not exceed 7 days due to the risk of developing swelling of the nasal mucosa and increased secretion caused by increased cell sensitivity to the drug.
In one dose (injection) of the drug contains xylometazoline hydrochloride - 70 mcg, ipratropium bromide - 84 mcg.

Side effects

    nervous system: headache, dizziness, insomnia;
    digestive system: dry mouth, nausea, dyspepsia;
    sensory organs: increased intraocular pressure, eye pain, mydriasis, worsening in patients with angle-closure glaucoma, impaired vision;
    urinary system: difficulty urinating;
    respiratory system: dryness and irritation of the mucous membrane of the nasopharynx, nosebleeds, sneezing, sensation of itching and tingling, hypersecretion (nasal), nasal congestion (with prolonged and frequent use);
    cardiovascular system: palpitations, atrial fibrillation, supraventricular tachycardia, arrhythmia;
    skin: itching, skin rash, urticaria;
    allergic reactions: laryngospasm, angioedema (tongue, lips, face), anaphylactic reactions.
You should consult a doctor in case of aggravation of the described or other side effects.

Overdose

Due to the low systemic absorption, an overdose of Otrivin Complex is unlikely.
Symptoms of an overdose of xylometazoline: sweating, nausea, decreased body temperature, bradycardia, headache, disturbance of accommodation, respiratory depression, arterial hypertension, hypotension, coma. Palliative therapy under the supervision of a physician is recommended.
Symptoms of an overdose of ipratropium bromide: dry mouth, difficulty in accommodation, tachycardia, in severe cases, the development of symptoms from the central nervous system caused by the anticholinergic effect of the substance is possible. Palliative therapy is recommended, with severe overdose, cholinesterase inhibitors are indicated.

special instructions

Before applying the nasal spray, the nasal passages should be cleaned. The duration of continuous treatment should not exceed 7 days.
Avoid contact with the eyes and the skin around them, as this can lead to temporary blurred vision, irritation, pain, redness, and exacerbation of angle-closure glaucoma. If Otrivin Complex gets into the eyes, they should be washed with cold water. If you experience pain or blurred vision, a doctor’s consultation is recommended.

Influence on the ability to drive vehicles and complex mechanisms

In therapeutic doses, Otrivin Complex does not affect the ability to drive vehicles and other complex mechanisms that require the speed of psychomotor reactions.

Pregnancy and lactation

The use of Otrivin Complex in the first trimester of pregnancy is contraindicated.
In the II and III trimester and during lactation, the drug can be prescribed in the case when the expected benefit to the mother outweighs the possible risk to the fetus or child. Do not exceed recommended dose.

Use in childhood

Do not appoint Otrivin Complex for children and adolescents under the age of 18 years.

Drug interaction

    monoamine oxidase inhibitors, tricyclic and tetracyclic antidepressants: co-administration with a nasal spray is contraindicated;
    sympathomimetics: an increase in blood pressure is possible, in severe cases, stop using Otrivin Complex and conduct symptomatic therapy;
    preparations with anticholinergic activity: it is possible to enhance the anticholinergic action of ipratropium bromide.

Terms and conditions of storage

Store at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Shelf life is 3 years.

Reviews about Otrivin Complex

Reviews about Otrivin Complex are mostly positive. Patients note the rapid relief of nasal breathing and the elimination of increased nasal secretion in various diseases accompanied by rhinitis.
Among the minuses, a rather impressive list of side effects is noted, of which, judging by the reviews, the most common is dry nasal mucosa.

Terms of sell

You don't need a prescription to buy Otrivin Complex.