Lasolvan Rhino spray 82mcg/dose 10ml

Lasolvan Rhino instruction

You can buy Lasolvan Rhino here

Lasolvan Rhino is an anti-congestive agent for local use in ENT practice.

Release form and composition

Dosage form of Lasolvan Rhino is a nasal dosage spray: a clear solution of pale yellow color with the smell of eucalyptus (10 ml each in glass brown bottles equipped with a metering device and a nasal adapter with a protective cap, 1 bottle in a cardboard box).
Composition of 1 dose of the drug:
    active substance: tramazoline hydrochloride monohydrate - 82 μg (in terms of tramazoline hydrochloride);
    additional components: purified water - 66 358 mcg, povidone - 2101 mcg, glycerol 85% - 700 mcg, citric acid monohydrate - 270 mcg, sodium chloride - 183 mcg, sodium hydroxide - 154 mcg, magnesium sulfate heptahydrate - 49 mcg, hypromellose ( hydroxypropyl methylcellulose) - 35 μg, magnesium chloride hexahydrate - 35 μg, L-menthol (levomenthol) - 14 μg, benzalkonium chloride - 14 μg, racemic camphor - 14 μg, calcium chloride dihydrate - 11 μg, cineole (eucalyptol) - 7 μg, sodium bicarbonate - 1 mcg.

Pharmacodynamics

Tramazolin hydrochloride - the active substance of Lasolvan Rhino - is an alpha2-adrenergic agonist that has a vasoconstrictor effect. Due to the narrowing of the vessels after getting on the mucous membranes of the nose, the drug reduces their swelling, as a result of which the patency of the nasal passages is quickly restored and nasal breathing is facilitated.
The drug begins to act 5 minutes after instillation, its effect persists for 8-10 hours.

Pharmacokinetics

The pharmacokinetics of tramazoline in humans has not been studied. During studies on monkeys, rabbits and rats, it was found that when using the drug, 50 to 80% of the dose is absorbed orally or intranasally. Both tramazolin and its metabolites are distributed in all internal organs; the highest concentration with constancy was found in the liver.
The main metabolites of tramazoline after oral and topical administration are determined in the urine.
The elimination half-life makes 5–7 hours.

Indications for use

According to the instructions, Lasolvan Rhino is prescribed to relieve swelling of the mucous membrane and eliminate nasal congestion caused by acute respiratory infections and / or hay fever (rhinitis, hay fever).
Also, the drug can be recommended to facilitate the outflow of the contents of the sinuses with sinusitis and otitis media (eustachitis).

Contraindications

Absolute:
    atrophic rhinitis;
    angle-closure glaucoma;
    indications of a history of skull operations performed through the nasal cavity;
    children under 6 years old;
    I trimester of pregnancy;
    hypersensitivity to any component of the drug.
Relative (Lasolvan Rhino should be used with caution):
    heart disease
    arterial hypertension;
    hyperthyroidism;
    porphyria;
    pheochromocytoma;
    prostatic hypertrophy;
    simultaneous use of tricyclic antidepressants, MAO inhibitors (monoamine oxidase), antihypertensive or vasopressor drugs.

Instructions for use Lasolvan Rhino: method and dosage

Lasolvan Rhino is applied intranasally.
Adults and children from 6 years of age are prescribed 1 injection into each nostril. The frequency of instillations should not exceed 4 times a day. Before injection, it is recommended to clean the nasal passages.
The duration of treatment is 5-7 days.
Use of the drug:
    Remove the protective cap from the bottle.
    Before first use, press the metering device a few times into the air until a steady cloud of aerosol appears.
    Keeping your head straight, insert the tip into the nostril and press once on the dispensing device.
    Repeat the procedure for the second nasal passage.
    Remove tip and inhale normally through nose.
    Put a protective cap on the bottle.
After each use, the tip is recommended to be cleaned.

Side effects

Classification of registered side effects according to the frequency of development: often - from ≥ 1% to <10%, infrequently - from ≥ 0.1% to <1%, rarely - from ≥ 0.01% to <0.1%, unspecified frequency - the frequency of these phenomena is not possible to assess, their relationship with the use of the drug is regarded as possible, they are registered during post-marketing use.
Lasolvan Rhino may cause the following adverse reactions:
    on the part of the respiratory system: often - nasal discomfort; infrequently - rhinorrhea, dry nose, sneezing, swelling of the nose; rarely - nosebleeds;
    from the cardiovascular system: infrequently - palpitations; unspecified frequency - increase in blood pressure, arrhythmia, tachycardia;
    from the immune system: undetermined frequency - hypersensitivity reactions;
    from the gastrointestinal tract: infrequently - nausea;
    on the part of the skin and subcutaneous tissues (as symptoms of hypersensitivity): unspecified frequency - rash, skin edema, itching;
    from the nervous system: rarely - taste disturbances, dizziness; infrequently - a headache; unspecified frequency - sedation, drowsiness;
    mental disorders: infrequently - anxiety; unspecified frequency - insomnia, hallucinations.

Overdose

With an overdose of tramazoline, blood pressure (BP) can increase and tachycardia can occur, followed by them, especially in children, a sharp decrease in blood pressure, lower body temperature, the development of reflex bradycardia and shock are possible.
Considering the experience of using other alpha-adrenergic agonists, the clinical picture of intoxication may be unclear, due to the probability of a change in the phases of stimulation and depression of the central nervous system (CNS) and the cardiovascular system (CVS), especially in children. Symptoms of central nervous system stimulation: agitation, anxiety, hallucinations, convulsions. Symptoms of central nervous system depression: lethargy, decreased body temperature, drowsiness, coma.
Also, in case of an overdose, the following symptoms may develop: respiratory failure (including respiratory failure, respiratory arrest), cyanosis of the lips, myosis, mydriasis, pallor, fever, sweating, impaired CCC functions (including bradycardia, cardiac arrest ), mental disorders.
In case of a nasal overdose of tramazoline, it is necessary to rinse the nose immediately. When symptoms of intoxication appear, symptomatic therapy is performed.

special instructions

Do not exceed recommended duration of treatment. If after 7 days no improvement is observed, you need to see a doctor who will decide on the advisability of continuing the therapy or the need to stop it.
Avoid contact with eyes.
With prolonged use, Lasolvan Rhino, like other vasoconstrictive nasal agents, can cause the development of chronic nasal congestion and inflammation, as well as atrophy of the nasal mucosa.

Influence on the ability to drive vehicles and complex mechanisms

Special studies on the effect of tramazoline on the rate of reactions and the ability to concentrate with its intranasal use have not been conducted. However, given the risk of side effects from the central nervous system and the psyche, such as sedation, drowsiness, fatigue, dizziness and hallucinations, it is recommended to refrain from performing potentially dangerous work and driving a car during treatment.

Pregnancy and lactation

According to long-term clinical experience with use, during pregnancy, Lasolvan Rhino does not have a negative effect. During lactation, the safety of the use of the drug is not confirmed.
In the first trimester of pregnancy, Lasolvan Rhino should not be used. In the II and III trimesters, as well as during breastfeeding, the use of the drug is possible, but only as prescribed by the doctor.

Use in childhood

In pediatrics, the drug is not used to treat patients under the age of 6 years.

Drug interaction

    antihypertensive drugs (especially those that affect the sympathetic nervous system): the development of various cardiovascular effects is possible;
    tricyclic antidepressants: the risk of arrhythmia increases;
    vasoconstrictor drugs, some antidepressants (MAO inhibitors, tricyclic antidepressants): blood pressure may increase.

Terms and conditions of storage

Store no more than 3 years at temperatures up to 25 ° C out of the reach of children.

Reviews for Lasolvan Rhino

The drug effectively eliminates the main symptoms of the common cold, such as nasal congestion and swelling of the nasal mucosa, and is well tolerated and practically does not cause side effects. According to reviews, Lasolvan Rhino helps in minutes to get rid of the symptoms of a runny nose and at the same time does not cause a feeling of dryness in the nose, characteristic of many other vasoconstrictor drugs.
However, it should be remembered that prolonged use of the drug is contraindicated, since in this case the risk of forming atrophy of the nasal mucosa is high.

Terms of sell

You can buy Lasolvan Rhino without a prescription.