Ambrobene Stopsussin drops 4mg + 100mg/ml 25ml

Ambrobene Stopsussin instruction

You can buy Ambrobene Stopsussin drops here

Composition

1 ml of the drug contains
active substances: guaifenesin 0.100 g, butamirate citrate 0.004 g;
excipients: ethanol 96% 0.300 g, floral flavor (aroma of alpine flowers) 0.002 g, purified water 0.007 g polysorbate-80 0.001 g, licorice extract liquid 0.003 g, propylene glycol up to 1,000 ml.

Pharmacodynamics

Combined drug with anti-cough and expectorant effects.
Butamirate has a peripheral local anesthetic effect on the sensitive nerve endings of the bronchial mucosa, which provides an antitussive effect.
Guaifenesin increases the secretion of bronchial glands and reduces the viscosity of mucus. Increased secretion is caused both by a direct effect on the bronchial glands - by stimulating the secretion of secretions from the bronchial glands and removing acidic glycoproteins from acinar cells, and by the reflex method, when the afferent parasympathetic fibers of the gastric mucosa are irritated and the respiratory center is inhibited. Increased tonus of the vagus nerve (n. Vagus) stimulates the production of bronchial secretions. The mucus produced by the bronchial glands enhances the activity of the ciliary epithelium, which facilitates the evacuation of mucus from the bronchi and its coughing.

Pharmacokinetics

When ingested butamirate, citrate is rapidly and completely absorbed. Communication with plasma proteins is 94%. Metabolized to form
2 metabolites that also have an antitussive effect. Metabolites are excreted mainly (90%) by the kidneys and only a small part - through the intestines.
The half-life (T½) is 6 hours.
When taken orally, guaifenesin is rapidly absorbed from the gastrointestinal tract. Communication with plasma proteins is negligible. Guaifenesin is rapidly metabolized, with the formation of inactive metabolites that are excreted by the kidneys. T½ - 1 hour

Indications for use

Dry, irritating, difficult to stop cough of various etiologies; cough relief in the pre- and postoperative period.

Contraindications

Hypersensitivity to the components of Ambrobene Stopsussin, children up to 6 months, the first trimester of pregnancy, myasthenia gravis.

Carefully

Ambrobene Stopsussin should be used with caution in patients with a tendency to develop drug dependence, with liver disease, alcoholism, epilepsy, brain diseases, as well as in children and pregnant and lactating women.

Use during pregnancy and during breastfeeding

Controlled clinical trials on the effect of Ambrobene Stopsussin drops on pregnant women or animal studies have not been conducted.
When taking guaifenesin in the first trimester of pregnancy, more frequent cases of the possible formation of an inguinal hernia in the neonatal period were described. Ambrobene Stopsussin drops should not be taken during the first 3 months of pregnancy. The use of the drug in the second and third trimesters of pregnancy is possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
It is not known whether butamirate and guaifenesin pass into breast milk. Due to insufficient information on the use of these drugs during breastfeeding, the risk of side effects in infants cannot be explicitly ruled out. The use of the drug during breastfeeding is possible in cases where the expected benefit to the mother outweighs the potential risk to the baby.

Dosage and administration

Ambrobene Stopsussin is taken after meals, the corresponding number of drops is dissolved in 100 ml of liquid (water, tea, fruit juice, etc.). If a syringe for dosing is attached to the drug, you can use it to accurately set the drug.
Dose depending on the patient’s body weight:
    up to 7 kg, 8 drops 3-4 times a day,
    7-12 kg, 9 drops 3-4 times a day,
    12-20 kg, 14 drops 3 times a day,
    20-30 kg, 14 drops 3-4 times a day,
    30-40 kg, 16 drops 3-4 times a day,
    40-50 kg 25 drops 3 times a day,
    50-70 kg, 30 drops 3 times a day,
    more than 70 kg, 40 drops 3 times a day.
If the condition worsens or there is no improvement within 3 days, you should consult a doctor.
You can use drops Ambrobene Stopsussin without a doctor’s prescription for no more than 7 days.

Side effects of Ambrobene Stopsussin

Subject to the recommended dosage regimen, patients usually tolerate the drug well. Digestion disorders (nausea, lack of appetite, stomach pain, vomiting, diarrhea), headaches, dizziness, and drowsiness, which are found in about 1% of patients, are most commonly reported. These side effects usually decrease after a dose reduction. Skin allergic reactions have also been observed.
The frequency of adverse reactions below was determined according to the following criteria: very often (> 1/10); often (> 1/100 - <1/10); infrequently (> 1/1000 - <1/100); rarely (> 1/10000 - <1/1000); very rarely (<1/10000), including individual messages.
From the nervous system: often - anorexia, headache.
From the side of the organ of hearing and balance: often - dizziness.
From the digestive system: often - nausea, pain in the stomach, vomiting, diarrhea.
On the part of the skin and subcutaneous fat: very rarely - rashes, urticaria.
From the kidneys and urinary tract: very rarely - urolithiasis.
In case of any side effects, including effects not listed in the instructions for use, please inform your doctor.

Overdose

Symptoms: In case of an overdose, signs of toxic effects of guaifenesin prevail: drowsiness, muscle weakness, nausea and vomiting. Perhaps the development of urolithiasis.
Treatment: In case of overdose, consult a doctor. Guaifenesin does not have a specific antidote. Prescribe gastric lavage, taking activated charcoal, symptomatic therapy aimed at supporting cardiovascular, respiratory and renal functions, electrolyte balance.

Interaction with other drugs

Guaifenesin enhances the analgesic effect of paracetamol and acetylsalicylic acid; enhances the sedative effect of alcohol, sedatives, hypnotics and general anesthetics on the central nervous system; enhances the effect of muscle relaxants.
False results can be obtained when determining the concentrations of vanillylindic and 5-hydroxyindoleacetic acid using nitrosonaphthol as a reagent. Therefore, the use of drugs containing guaifenesin should be stopped 48 hours before urine collection for this analysis.

special instructions

During treatment with the drug is not recommended to drink alcoholic beverages.
If symptoms persist or intensify, seek medical attention.
Ambrobene Stopsussin contains 35.6 vol. % ethanol, the maximum single dose of the drug (40 drops) contains up to 0.322 g of ethanol. This should be considered when prescribing the drug to patients suffering from liver diseases, epilepsy, pregnant and lactating women and children.
Drops Ambrobene Stopsussin should not be prescribed for productive cough in patients suffering from prolonged or chronic cough (including smoking), bronchial asthma, chronic bronchitis or emphysema.
If you missed the drug, do not increase the next dose to compensate for the missed one. If you have questions about taking the drug, contact your doctor.

Impact on the ability to drive vehicles and mechanisms

Ambrobene Stopsussin drops can have an adverse effect on activities that require an increased concentration of attention and speed of psychomotor reactions (for example, driving a car, working with mechanisms and high-altitude work).

Release form

Drops for oral administration, 4 mg + 100 mg / ml.
On 10, 25 and 50 ml in dark glass bottles with a polyethylene dropper, a cover with opening control.
50 ml in dark glass bottles with a polyethylene dropper, a cover with an opening control and a plastic syringe for dosing.
Each bottle is placed in a cardboard box along with instructions for use.

Storage conditions

In a dark place at a temperature of 10 to 25 ° C.
Keep out of the reach of children.
Shelf life - 5 years. Do not use after the expiration date indicated on the package.

Terms of sell

You don't need a prescription to buy Ambrobene Stopsussin.