Bimatan drops 0.03% 2.5ml


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Bimatan instruction for use

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Release form and composition

The clear solution is packaged in 2.5 ml plastic bottles with a dropper nozzle. Manufactured by Bimatan Bimatan, SENTISS PHARMA Pvt. Ltd. (India).
The active ingredient is bimatoprost (0.32 g), additional components are sodium chloride (8.3 mg), (0.05 mg), water for injection, citric and hydrochloric acid, caustic soda. The required level of acid-base balance is maintained by the last components.

Bimatan's action

Bimatoprost is a synthetic prostamide linked to prostaglandin F2α (PGF2α). When distributed in the sclera and cornea, it accelerates metabolic processes, stimulates the outflow of secretions through the trabecular network, and increases the rate of uveoscleral outflow.
It is absorbed into the systemic circulation unchanged. Forms metabolites after oxidation. Plasma protein binding is 88%.
Intraocular pressure decreases after application for a week, remains at the same level throughout the entire therapeutic course and for 2-3 months after the end of treatment. The initial effect is seen 4 hours after a single administration, the maximum effect develops within 8-12 hours. 67% of metabolites are removed through the urinary system, 25% - by the intestines.
In laboratory tests, the half-life was diagnosed after intravenous administration of bimaprost. It was 45 minutes long. The desired effect appears a week after regular use.

Indications and contraindications for use

Bimatan is prescribed for open-angle glaucoma and ophthalmic hypertension in patients over 18 years of age. It can be used in monotherapy or introduced into a therapeutic course, together with beta-blockers.
    hypersensitivity to the main active ingredient (bimaprost), or additional ingredients;
    age up to 18 years.
When testing the drug, no effect on changes in heart rate and blood pressure was noted. Therefore, it is allowed to use it for diseases of the cardiovascular system of various etiologies.

During pregnancy

Since experiments on animals have shown the toxic effect of bimatoprost on fetal development when used in high doses, it is better to refuse the drug in all trimesters. Prescription is possible, but only when the benefit to the mother outweighs the potential risk to unborn babies.

During lactation

The active active ingredient is excreted in breast milk, therefore, it is better to refuse treatment when breastfeeding. According to the results of animal studies, negative effects on newborns have been described. If Bimatan therapy is recommended, lactation will have to be stopped.
Thanks to breast milk, a child of the first year of life develops immunity, increases resistance to diseases of various kinds, and normalizes psychophysical development. Given the high benefits of breastfeeding for newborns and the possibility of replacing Bimatan with similar means, they try not to prescribe eye drops during lactation.

Method of administration and dosage

It is necessary to pay attention: if only one eye is affected, the drug is not injected into the second. The installation is carried out once, at the same time, in order to maintain the intraocular pressure at the same level. Before handling, be sure to wash your hands. The lower eyelid is pulled back and 1 drop is injected into the conjunctival sac.
If the patient has missed the time, it is recommended to drop the next dose as soon as possible. Changes in plasma concentration have a negative impact on the effectiveness of treatment. When using several eye preparations, after Bimatan has been dripped, you need to wait at least 5 minutes.

Side effects

In case of intolerance to bimatoprost and violation of recommendations for use, side effects of local and systemic action were noted. From the side of the visual organs, the development of macular edema, cystic uveitis, periorbital erythema, blepharospasm, eyelid retraction, iritis was described.
Patients often complain of burning and itching in the eyes, irritation, visual disturbances - blurred vision, dryness and pain in the eyes, sensation of a foreign body. The rapid growth of eyelashes, an increase in the frequency of exacerbation of herpes are noted. With long-term use, ophthalmologists diagnosed superficial punctate keratitis, allergic conjunctivitis, increased iris pigmentation. In some cases (frequency not established), enophthalmos was noted (change in the size of the eyeball). Often - vascular disorders - expansion or spasms, causing changes in intraocular pressure.
Systemic side effects include:
    headache and dizziness (in rare cases);
    hirsutism (male pattern hair growth);
    general disorders and disorders at the injection site;
    violation of coordination (extremely rare, in isolated cases).
Infrequently appeared: asthenia, decreased blood pressure, corneal calcification. In laboratory studies of biochemical analyzes, deviations in the indicators of ASaTs and ALaTs were often determined.
When applied topically, overdose was not observed. Inadvertent oral ingestion has resulted in reactions described as systemic side effects. To stop negative manifestations, symptomatic therapy is required.

Special instructions for Bimatan

When prescribing the drug, patients are informed about the possible development of such changes as increased pigmentation of the iris, darkening of the skin of the eyelids and eyelashes, the appearance of increased hair growth. This can provoke an aesthetic disturbance in appearance - differences between the eyes. (After all, the introduction into one eye is more often prescribed). Not only the iris darkens, but also the skin of the eyelids. Not everyone returns to the original shade.
In patients with aphakia and rupture of the posterior lens capsule, bacterial and ocular infections (herpes simplex or iritis / uveitis), use is possible, but only under the supervision of the attending physician. The use is not described if there is a history of dysfunction of external respiration, heart failure, AV block II and III degrees.
If necessary, wear contact lenses, after the introduction of drops, you need to wait 15 minutes until they are completely distributed. Benzalkonium chloride, an auxiliary component of the solution, is absorbed by the soft plates, causing them to become cloudy, which further increases eye irritation. This preservative increases the risk of corneal ulceration, so patients with dryness need to be monitored.
It is very important not to allow the dropper to touch the surface of the eye. Improper handling increases the risk of contracting a bacterial infection, since the attachment is reusable.
Drops with bimatoprost do not affect coordination. The patient can drive a vehicle 15-20 minutes after the injection. The gap is necessary, since after the introduction, temporary clouding of the gaze is possible.

Storage conditions

Before opening, the bottle can be stored both in the refrigerator, on the shelf, and at room temperature. Useful properties are retained for 3 years at T + 2-25 ° C. After opening the bottle, use within 1 month (30 days). The started medicine must be put in the refrigerator.
Do not leave packaging with drops freely available, especially when small children are at home. Accidental oral use can lead to toxicity.


When prescribing the drug, doctors warn of a possible side effect and recommend taking a biochemical analysis once every 2-3 months to monitor the indicators by which the state of not only the liver, but also other internal organs - the heart and kidneys - is analyzed. It is advised not to increase the recommended dosage, to follow the recommendations specified in the instructions:
Anatoly Mikhailovich, ophthalmologist
“When prescribing a drug, I always warn about possible side effects. If patients, more often women, refuse, despite the need to be introduced to the therapeutic course, I treat with understanding, replace it with another. Even less effective, but not causing skin darkening. "
Tatyana Vasilievna, optometrist
“Despite the long description of side effects, I came across in isolated cases. Therefore, I prescribe Bimatan for the treatment of open-angle glaucoma. Please "show up" 2 weeks after you start using it. Burning and stinging, arising immediately after administration, I do not consider the reason for the termination of therapy.
Patient reviews, both positive and negative:
Ilona Gennadievna, 54 years old
“The doctor prescribed for the treatment of glaucoma, I dripped for 2 months, it became easier. I did not feel any negative influences. But a neighbor with the same diagnosis complained of burning sensation, headache, insomnia. But I asked the doctor to repeat the therapy, it became much easier, my head stopped hurting. "
Ivan Arkadievich, 63 years old
“From time to time I drip it Bimatan, then Betalmik then Latisse. I don't feel any difference. Only from lenses I switched to glasses. If used during treatment, the eyes turn red and even seem to have deteriorated vision. Bimatan has a comfortable dropper, he has never scratched his eyeball. "
Antonina, 19 years old
“I don’t have glaucoma, but my friends advised me to drip into my eyes for the growth of eyelashes. I do not recommend to anyone to repeat. Eyelashes grew a little, but my eyes began to pinch, my head often hurt. Now I understand that I acted stupidly, I had to treat allergic conjunctivitis. "

Terms of sell

You don't need a prescription to buy Bimatan.