Lorista HD tabs 100mg + 25mg #60

Lorista HD instruction

You can buy Lorista HD on this page

Release form, composition and packaging

Lorista HD tablets are covered with a yellow-green film. The contours are oval with a slight bulge. One unit contains 0.1 g of potassium losartan and 25 mg of hydrochlorothiazide. Auxiliary chemicals are attached to the active ingredients:
    gelatinized starch;
    porous cellulose;
    milk sugar;
    magnesium salt and stearic acid.
The film formula contains methyl hydroxypropyl cellulose, ethylene glycol polymer, yellow pigment, titanium dioxide, crystalline powder from the silicate class. The chemical product is packed in blisters and cartons.

Pharmachologic effect

Lorista HD has a combined effect. The active component is a selective antagonist of angiotensin neurons of the second type of non-protein genesis. In experiments outside a living cell and on living organisms, this substance with its active carboxylic derivative counteracts all important processes involving peptides formed in the body from angiotensinogen. Containment occurs regardless of the direction of their formation, causing stimulation of renin in the blood plasma and reducing the concentration of the main mineralocorticosteroid hormone, which is synthesized by the adrenal cortex. Losartan indirectly leads to the activation of AT2 type neurons, but does not inhibit carboxycatepsin, an enzyme involved in the cleavage of a peptide that expands the lumen of blood vessels, as a result of which blood pressure decreases. The total effect of a chemical can be defined as:
    decrease in total peripheral vascular resistance;
    decrease in pressure in the small circle of blood supply;
    decrease in afterload;
    increased diuretic effect;
    increased exercise tolerance in persons with prolonged cardiac dysfunction;
    reducing the risk of cardiac muscle hypertrophy.
The use of a chemical product once a day causes a significant decrease in diastolic and systolic pressure. It keeps its performance at a constant level when the achieved state is consistent with biological cyclic processes. There are no signs of withdrawal and no effect on heart rate. How to take Lorista HD depends on age, condition of the renal and hepatobiliary systems. Its effectiveness is noted in men and women, young and older generations. The second active ingredient, hydrochlorothiazide, is a thiazide diuretic component. Its mechanism of operation is determined by damage to the reverse absorption of K, Mg, Cl, Na ions, as well as H2O in the Henle loop. It slows down the excretion of calcium ions and uric acid compounds. Diuretic signs appear within 1-2 hours after administration. The maximum values ​​of urination occur within 4 hours, and the total duration is from 6 to 12 hours. According to doctors, the first positive shifts in blood pressure readings are noted on the 3-4th day of therapy. But to achieve a sustainable effect, it will take up to a month of systematic use of the medication. Pharmacokinetic parameters of active materials with their combined administration are identical to the same values ​​with monotherapy with each of them. The substance is well absorbed through the walls of the digestive tract. At the same time, its use with food does not affect the concentration in the blood serum. The maximum density occurs one hour after administration. The bioavailability characteristic remains at the level of 33%. Almost all of losartan and hydrochlorothiazide binds to plasma protein, a simple, water-soluble protein. The level of penetration through the hepatoencephalic barrier is minimal. A large amount of drug material is cleaved during the "first pass" through the liver cells. As a result, one active derivative and several inactive ones are formed. Hydrochlorothiazide is absorbed into the blood by 60-80%. The maximum concentration reaches within 1.5-5 hours. It is not broken down in the body, but is removed through the renal system.

Indications

It is prescribed for high blood pressure to reduce the likelihood of developing cardiac pathologies in persons suffering from hypertension and an increase in the mass of the left ventricular myocardium.

Contraindications

Lorista HD is not allowed to be discharged when diagnosing:
    pathology associated with the lack of urine flow into the bladder;
    severe renal dysfunction;
    high levels of potassium in the blood;
    dehydration due to the use of diuretics;
    low potassium levels against the background of refractory arterial hypertension;
    lack of an enzyme that hydrolyzes milk sugar to form dextrose and galactose;
    hereditary disease against the background of impaired metabolism on the way of converting galactose (simple sugar) into dextrose;
    hypersensitivity to the active ingredients of the drug.
The chemical product should be used with caution in case of imbalance in the water-electrolyte composition of the blood substance, bilateral vasoconstriction of the kidneys, diabetes mellitus, increased calcium levels, bronchial asthma.

Dosage

Lorista HD is consumed orally before or after meals, which does not matter. Complex administration with other substances that lower the pressure is possible. You need to start by taking one tablet. Due to the reduced BCC, when the patient takes diuretics in large doses, pressure reduction therapy is allowed to begin only after the withdrawal of diuretics and correction of the pathology, when the volume of circulating blood fluid is insufficient. To minimize the risk of heart failure and death, the usual initial dose of the drug is 0.05 g per day.

Side effects of Lorista HD

Collateral phenomena after taking an antihypertensive drug arise from:
    central nervous organization - cephalalgia, lack of sleep, rapid fatigue, dizziness;
    heart and blood vessels - sharp fluctuations in pressure when changing body position, increase or decrease in heart rate, inflammation of the walls of blood vessels;
    respiratory organs - cough, infection of the upper respiratory passages, inflammation of the pituitary membrane of the throat, swelling of the nasal mucosa;
    the digestive department - diarrhea, abdominal pain in the abdominal cavity, hepatitis;
    musculoskeletal system - pain in the muscles, spine;
    structures of blood formation - anemia, rheumatic or allergic purpura;
    clinical parameters - increased density of hemoglobin, urea, creatinine in the blood;
    immunity - allergenic reactions in the form of itching, urticaria, angioedema of the tongue, larynx, face, respiratory obstruction.
Other accidental phenomena against the background of the use of Lorista HD develop in the form of weakness, edema in the extremities, pain in the chest.

Overdose

The characteristic signs of taking overdose are expressed in a sharp decrease in pressure, fluctuations in the heart rate upward or downward. Therapy consists in carrying out increased diuresis. Extrarenal blood cleansing is not effective.

Drug interactions

Clinical experiments have not shown a significant pharmacokinetic effect on the body when taken simultaneously with ketoconazole, erythromycin. Fluconazole and rifampicin reduce the content of active derivatives. Simultaneous use with diuretics that preserve the level of potassium can lead to an increase in the amount of this chemical element in the blood fluid. Non-steroidal anti-inflammatory drugs, selective cyclooxygenase inhibitors reduce the capabilities of diuretics and other antihypertensive substances. With the combined administration of hydrochlorothiazide with alcohol, barbiturates, narcotic materials, orthostatic hypotension may occur. When combining the active ingredient with sugar-reducing chemical products, it is possible to adjust the portion of the latter. Coletipol and colestyramine impair the absorption of hydrochlorothiazide.

Special instructions

It is allowed to buy Lorista HD for complex use with other medicines that lower blood pressure. The drug is able to increase the density of carbonic acid diamide and creatinine in the plasma substance of the blood in persons with bilateral vasoconstriction. Hydrochlorothiazide increases the pressure drop, reduces the excretion of calcium with urine, increases the density of polycyclic lipophilic alcohol, and provokes the formation of metabolism in bone tissue. The presence of milk sugar in the drug requires careful use in the disorder of the metabolic mechanism associated with dairy products. Therefore, it is not prescribed for patients with lactose intolerance, or impaired metabolism during the conversion of galactose into glucose. A significant effect of the drug on the ability to drive a car, perform work associated with increased concentration of attention has not been established. But since at the first stage of the course of treatment, the appearance of dizziness is not excluded, then you need to assess your condition to prevent serious consequences. The combination of hydrochlorothiazides with glucocorticosteroids leads to a drop in the level of electrolyte components, especially potassium. Diuretics lower the lithium balance, which will increase its toxicity. Therefore, the combined administration is prohibited.

Pregnancy and lactation

There is no information about the use of Lorista HD during the period of bearing a child. The danger to the fetus when the mother uses an antihypertensive substance occurs in the second and third trimester. Diuretic materials should also not be consumed, so as not to cause jaundice during intrauterine development and after birth, as well as a decrease in the level of platelets in a woman. Treatment with diuretics does not relieve toxicosis. After pregnancy is diagnosed, treatment with Lorista HD is discontinued. The same should be done when feeding a baby with breast lactose. If it is impossible to cancel the therapy, the child is transferred to artificial nutrition.

Childhood use

The level of the drug's effect on the body of children and adolescents has not been established.

With impaired renal function

A medication is not prescribed in case of severe disorders in the performance of the urinary system, as well as in patients undergoing extrarenal blood purification.

For violations of liver function

Not recommended for persons with dysfunction of the hepatobiliary structure.

Use in the elderly

There is no special selection of a portion of the medicine for patients of the older age group.

Terms and conditions of storage

The pharmaceutical product is included in the list B. It must be saved at a temperature of no more than 30 ° C. The retention time of the effectiveness of the chemical product does not exceed 2 years.

Terms of sell

You can buy Lorista HD without a prescription.