Cordinic (Kordinik) tabs 10mg #60

Cordinic user manual

Reed more and buy Cordinic here

Cordinic is a drug with antianginal action.

Release form and composition

The dosage form of the release of Cordinic is tablets: white with a slight grayish-yellowish tinge, flat-cylindrical, round, with a bevel (in a cardboard box 2, 3 or 6 blisters of 10 tablets each).
Composition of 1 tablet:
    active substance: nicorandil - 10 or 20 mg;
    auxiliary components (10/20 mg): potato starch - 5/10 mg; calcium stearate - 1/2 mg; microcrystalline cellulose - 84/168 mg.

Pharmacodynamics

Nicorandil has an antianginal effect based on a combination of the nitrate-like properties of the substance and its ability to open potassium channels. Due to the opening of potassium channels, nicorandil provides hyperpolarization of the cell membrane, and the nitrate-like effect consists in an increase in the intracellular content of cyclic guanyl monophosphate. These pharmacological effects cause relaxation of smooth muscle cells and cellular protection of the myocardium during ischemia.
The hemodynamic effects of Cordinic are expressed in a balanced decrease in pre- and afterload (this is in contrast to nitrates and slow calcium channel blockers, which act predominantly on pre- or afterload, respectively). Thus, nicorandil exerts minimal stress on the ischemic myocardium.
The drug does not affect myocardial contractility, therapy practically does not lead to a change in heart rate (heart rate). Reduces systemic blood pressure (blood pressure) by less than 10%; in patients with ischemic stroke, it has a beneficial effect on cerebral circulation.
Nicorandil has no effect on glucose metabolism and lipid metabolism. It relieves an attack of angina pectoris with a decrease in pain syndrome within 4-7 minutes after taking it under the tongue, complete relief is observed within 12-17 minutes.

Pharmacokinetics

Nicorandil is completely and rapidly absorbed from the gastrointestinal tract. The time to reach the maximum concentration of the substance is 30-60 minutes. It is not subject to intensive metabolism in the liver, the half-life is 50 minutes. It is excreted mainly by the kidneys.
The binding of nicorandil to blood plasma proteins is negligible. The free fraction in blood plasma is approximately 75%.
Pharmacokinetic parameters depend on the patient's age, the presence of concomitant kidney / liver pathology, and the conduct of combined therapy only to a small extent.

Indications for use

    angina attacks (relief);
    stable angina pectoris (prevention of seizures as monotherapy in patients with intolerance to beta-blockers and slow calcium channel blockers, or in combination with other antianginal drugs).

Contraindications

Absolute:
    acute myocardial infarction (including the period 3 months after it);
    unstable angina;
    collapse, cardiogenic shock;
    arterial hypotension (with systolic blood pressure <100 mm Hg);
    chronic heart failure of III or IV functional class according to the NYHA classification;
    atrioventricular block II and III degree;
    left ventricular failure with low filling pressure;
    severe bradycardia (with heart rate <50 beats / min);
    combined use with phosphodiesterase-5 inhibitors (vardenafil, sildenafil, tadalafil);
    pregnancy and breastfeeding period;
    age under 18;
    individual intolerance to any component of the drug.
Relative (Cordinic is appointed under medical supervision):
    heart rhythm disturbances;
    arterial hypotension;
    atrioventricular block I degree;
    Prinzmetal's angina;
    impaired renal / hepatic function;
    pulmonary edema;
    hypovolemia;
    angle-closure glaucoma;
    anemia;
    hyperkalemia.

Instructions for the use of Cordinic: method and dosage

Cordinic is taken orally with water. Food intake has no effect on the effectiveness of the drug.

Long-term therapy (prevention of attacks) of stable angina

At the beginning of treatment, Cordinic is prescribed 10 mg 2 times a day.
The doctor selects an effective therapeutic dose individually, depending on the duration and severity of the disease. The standard dose is 10-20 mg 2-3 times a day. The maximum is 80 mg per day.
In cases of headache, the dose of the drug is reduced.

Relief of angina attacks

Cordinic should be taken immediately at the first signs of an attack of angina pectoris at a dose of 20 mg (under the tongue, without swallowing, until it is completely dissolved).

Side effects

    digestive system: nausea, vomiting, unpleasant feelings in the stomach, a feeling of fullness in the stomach, stomatitis (in extremely rare cases); in isolated cases - increased activity of hepatic transaminases (aspartate aminotransferase and alanine aminotransferase), alkaline phosphatase;
    nervous system: weakness, headache (the violation can be mitigated by lowering the dose, the cancellation of therapy is not required), tinnitus, dizziness, insomnia;
    cardiovascular system: tachycardia, palpitations, lowering blood pressure, peripheral edema, flushing of the skin of the face;
    others: allergic reactions.

Overdose

The main symptoms: tachycardia, a marked decrease in blood pressure.
Therapy: gastric lavage, the appointment of activated charcoal (especially in the first 2 hours after an overdose), elevated position of the limbs, maintaining the function of the cardiovascular system, symptomatic and supportive treatment, intravenous dopamine and calcium gluconate. The use of hemodialysis is possible.

Special instructions

It is necessary to cancel Cordinic gradually.
It is possible that the existing disturbances in the heart rhythm increase.
During the course, ECG indicators, the content of sodium and potassium ions in the blood, and blood pressure should be monitored.

Influence on the ability to drive vehicles and complex mechanisms

Patients during the period of therapy when driving vehicles should be careful.

Application during pregnancy and lactation

According to the instructions, Cordinic is not prescribed to women during pregnancy / lactation (there is no information confirming the safety of the drug).

Childhood use

Patients under the age of 18 are not prescribed therapy (there is no information confirming the safety of the drug).

With impaired renal function

Cordinic for renal failure is prescribed with caution.

For violations of liver function

Cordinic with hepatic failure is prescribed with caution.

Drug interactions

Possible interactions:
    antidepressants, phosphodiesterase-5 inhibitors (vardenafil, sildenafil, tadalafil), vasodilators, antihypertensive drugs, tricyclic antidepressants, diuretics, beta-blockers, monoamine oxidase inhibitors, ethanol: increased antianginal action;
    sapropterin: lowering blood pressure below normal.

Terms and conditions of storage

Store in a place protected from light and moisture at temperatures up to 25 ° C. Keep out of the reach of children.
Shelf life is 2 years.

Terms of sell

You don't need a prescription to buy Cordinic.