Ceftriaxone injections 1gr #1

User manual for Ceftriaxone

You can buy Ceftriaxone here

The drug is produced in powder form, used for intramuscular or intravenous administration.

Composition and release form

The manufacturer produces Ceftriaxone in the form of a white powder used to prepare the solution for injection. It is used for intramuscular and intravenous administration. The powder is packaged in glass vials, each of which contains 500 mg or 1 gram of the drug.
Bottles of 5.10, 50 pcs. Packed in cartons. The drug is stored in a dark, dry place inaccessible to children, at a temperature not exceeding 20 ° C. Shelf life is 2 years.
Clinical and pharmacological group: III generation cephalosporin.

What is ceftriaxone used for?

Ceftriaxone according to the instructions prescribed for such infectious and inflammatory diseases such as:
    wound infections;
    meningitis;
    sepsis;
    gonorrhea;
    infectious diseases of the joints and bones;
    disseminated Lyme borreliosis in the early and late stages;
    infectious diseases of the abdominal organs (infections of the biliary tract and gastrointestinal tract, peritonitis);
    infectious diseases of the skin and soft tissues;
    infectious diseases in immunocompromised patients;
    infectious diseases of the genital organs;
    infectious diseases of the urinary tract and kidneys;
    infectious diseases of the pelvic organs;
    infectious diseases of the ear, throat, nose;
    infectious diseases of the respiratory tract.
The indications for ceftriaxone are the prevention of infections after surgery.

pharmachologic effect

Third-generation antibiotic that slows down the formation of the structural elements of the shell of bacteria. At the same time, the drug oxidizes enzymes that ensure the strength of the cell wall and leads to the complete impossibility of its recovery.
    The main percentage of the active form of the drug is excreted by the kidneys within 48 hours, and can be partially excreted with bile. Slow elimination is observed in elderly patients, children, newborns and renal failure. In the latter case, the formation of clusters and infiltrates.
Ceftriaxone is completely absorbed, one and a half hours after intramuscular administration (its maximum concentration is observed in the blood). It has the ability to build reversible bonds with blood proteins and stay in the body for a long time, without breaking the active form. Easily penetrates all organs, including cerebrospinal fluid and bone tissue. May be passed to child with mother's milk.

Instructions for use

Ceftriaxone is administered intramuscularly and intravenously. Use only freshly prepared solutions.
    For intramuscular administration, the drug is dissolved in sterile water for injection in the following ratios: 0.5 g is dissolved in 2 ml of water, 1 g in 3.5 ml of water. Intramuscular injections are injected into the upper outer quadrant of the gluteus maximus rather deeply. It is recommended to introduce no more than 1 g in one buttock. In order to eliminate pain at the injection site, it is possible to use 1% lidocaine solution.
    For intravenous administration, the drug is dissolved in sterile water for injection (0.5 g is dissolved in 5 ml, 1 g in 10 ml of solvent). Injected slowly intravenously (within 2 - 4 min). For intravenous infusions, dissolve 2 g of the drug in 40 ml of a solution that does not contain calcium ions (solution of sodium chloride 0.9%, solution of glucose 5% or 10%, solution of levulose 5%). A dose of 50 mg / kg of body weight and more should be administered intravenously for at least 30 minutes. For children: - Newborns (up to two weeks of age) and premature daily dose is 20-50 mg / kg body weight 1 time per day (the dose of 50 mg / kg body weight is not allowed to exceed).
With bacterial meningitis in newborns, the initial dose is 100 mg / kg of body weight once a day (maximum 4 g). After isolating the pathogen and determining its sensitivity, the dose must be reduced accordingly; - from 3 weeks to 12 years - 50 - 80 mg / kg per day in 2 administrations (in children with a body weight of 50 kg and more, the dosage for adults should be observed); - for adults and children over 12 years old, the drug is administered 1 to 2 g once a day, if necessary up to 4 g (preferably in 2 administrations after 12 hours).
The duration of treatment with Ceftriaxone depends on the type of infection and the severity of the condition. After the disappearance of symptoms of infection and the normalization of body temperature, it is recommended to continue use for at least three days.
    For uncomplicated gonorrhea, adults inject once intramuscularly 0.25 g of Ceftriaxone.
    For the prevention of postoperative infections, adults are given 1 g once in 1/2 to 2 hours before the operation, in the form of infusions for 15 to 30 minutes at a concentration of 10-40 mg / ml.
In patients with impaired liver function, there is no need to reduce the dose if the kidney function remains normal. In patients with impaired renal function, there is no need to reduce the dose if liver function remains normal. In cases of preterminal renal failure severe with a CC of <10 ml / min, the daily dose of the drug should not exceed 2 g.
Patients on dialysis do not require additional drug administration after dialysis. However, it is necessary to control the serum ceftriaxone concentration in order to promptly adjust the dose, since the rate of excretion of the drug in these patients may decrease.
With a combination of severe renal and hepatic insufficiency, the concentration of ceftriaxone in plasma should be regularly determined and, if necessary, its dose should be adjusted.

Contraindications for Ceftriaxone

There are no special contraindications for the injection of Ceftriaxone except for its high sensitivity to its composition or to the antibiotics of the cephalosporins group, penicillins, and carbapenems.
Careful use of the drug requires for infants who have hyperbilirubinonemia, for premature babies, for patients with renal / hepatic insufficiency, for lactating and pregnant women.

Side effects of Ceftriaxone

Side effects of the drug appear as:
    dysfunctions of the digestive organs (nausea, vomiting, flatulence, taste disturbance, stomatitis, diarrhea, glossitis, sludge formation in the gallbladder and pseudo cholelithiasis, pseudomembranous enterocolitis, dysbacteriosis, candidosis, and other superinfection).
    hypersensitivity reactions - eosinophilia, fever, pruritus, urticaria, edema, skin rash, multiforme (in some cases, malignant) exudative erythema, serum sickness, anaphylactic shock, chills.
    disorders of hemopoiesis (anemia, including hemolytic; lympho-, leuco-, neutro-, thrombocyto-, granulocytopenia; thrombotic and leukocytosis, hematuria, basophilia, bleeding from the nose).
    headache and dizziness.
    oliguria.
If the drug is administered intravenously, inflammation of the venous wall is possible, as well as pain along the vein. The introduction of the drug into the muscle is accompanied by pain at the injection site.

Pregnancy and lactation

Use of the drug during pregnancy is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus, because ceftriaxone crosses the placental barrier.
If necessary, the use of the drug during lactation should decide on the termination of breastfeeding, because ceftriaxone is excreted in breast milk.

Storage conditions

In a dry place protected from light, at a temperature not exceeding 30 ° C. Keep out of the reach of children.

Terms of sell

You don't need a prescription to buy Ceftriaxone.