Lordestin syrup 0.5mg/ml 60ml

Lordestin syrup user manual

You can buy Lordestin syrup here

Composition

The syrup is clear, colorless, with an almond smell.
1 ml desloratadine hemisulphate 0.578 mg, which corresponds to the content of desloratadine 0.5 mg
Excipients: propylene glycol - 150 mg, sorbitol (non-crystalline liquid) 70% - 150 mg, citric acid - 4.6 mg, sodium citrate dihydrate - 1.26 mg, sodium cyclamate - 5 mg, hypromellose -2910 - 3.5 mg, disodium edetate dihydrate - 0.25 mg, almond flavoring - 0.75 mg, water - up to 1 ml.

pharmachologic effect

Histamine H1 receptor blocker. a drug

Indications

- allergic rhinitis (relief or elimination of sneezing, nasal congestion, removal of mucus from the nose, itching in the nose, itching of the palate, redness and itching of the eyes, tearing);
- urticaria (reduction or elimination of pruritus, rash).

Contraindications for Lordestin syrup

- hypersensitivity to the drug;
- pregnancy and lactation;
- age up to 1 year;
- hereditarily transmitted disorders - intolerance or impaired absorption of sorbitol, deficiency of sorbitol dehydrogenase (Lordestin syrup 0/5 mg / ml contains sorbitol. Intolerance or impaired absorption of sorbitol is often accompanied by intolerance to other sugars, such as fructose).

Carefully

- severe renal failure.

Side effects

In children under 2 years of age with the use of 0.5mg / ml of Lordestin syrup, the following adverse reactions were noted, the frequency of which was higher than with the use of placebo: diarrhea, fever, insomnia.
In children aged 2 to 11 years with the application of 0.5 mg / ml of Lordestin syrup, the frequency of side effects was the same as with placebo.
In adults and adolescents (12 years and older), when administering 0.5 mg / ml of Lordestin syrup, the following adverse events were noted, the frequency of which was higher than with placebo: increased fatigue (1.2%), dry mouth (0.8%), headache (0.6%).
When administering Lordestin syrup 0.5 mg / ml in adults and adolescents at the recommended dose of 5 mg per day, the incidence of drowsiness was no higher than with placebo.
During post-marketing use, other side effects were very rare (1/10 000 prescriptions (less than 0.01%)):
On the part of the immune system: allergic reactions (anaphylaxis, angioedema, pruritus, rash, urticaria, shortness of breath).
On the part of the nervous system: dizziness, drowsiness, hallucinations, psychomotor hyperactivity, convulsions.
From the side of the heart: tachycardia, palpitations.
On the part of the digestive tract: abdominal pain, nausea, vomiting, dyspepsia, diarrhea.
On the part of the liver and biliary tract: an increase in plasma bilirubin concentration, an increase in the activity of "liver" enzymes, hepatitis.
From the musculoskeletal and connective tissue: myalgia.
On the part of the skin and subcutaneous tissues: photosensitivity.
If the course of any of these reactions deteriorates or a new one occurs, you should immediately consult a doctor.

Interaction

When studying drug interactions with repeated co-administration of desloratadine with ketoconazole, erythromycin, azithromycin, fluoxetine and cimetidine, clinically significant changes in the concentration of desloratadine in the plasma ns were detected. Meal does not affect the effectiveness of the drug. Lordestin syrup 0.5 mg / ml does not enhance the effect of alcohol on the central nervous system.
No interaction with ketoconazole, erythromycin, azithromycin, fluoxetine and cimetidine was detected.

How to take, the course of administration and dosage

Inside Syrup should be taken regardless of the meal, washed down with a small amount of water.
Children aged 1 to 5 years: 1.25 mg each (2.5 ml of syrup) 1 time / day.
Children aged 6 to 11 years: 2.5 mg (5 ml syrup) 1 time / day.
Adults and adolescents from 12 years: 5 mg (10 ml of syrup) 1 time / day.
For proper dosing, use the supplied plastic dosing cup, graduated from 2.5 ml to 20 ml.

Overdose with Lordestin syrup

Symptoms

Receiving a dose that is five times the recommended one does not cause any symptoms. In clinical studies, daily use of desloratadine in adults and adolescents at a dose of up to 20 mg for 14 days was not accompanied by statistically or clinically significant changes in the cardiovascular system. In a clinical pharmacological study, the use of desloratadine at a dose of 45 mg / day (9 times higher than recommended) for 10 days did not cause prolongation of the QT interval and was not accompanied by the occurrence of serious side effects.

Treatment

In case of accidental ingestion of a large amount of the drug, you should immediately consult a doctor. Recommended gastric lavage, taking activated charcoal; if necessary, symptomatic therapy. Desloratadine is not excreted by hemodialysis, the effectiveness of peritoneal dialysis has not been established.

Special instructions

The shelf life of the drug after the first opening of the bottle is 28 days.

Use in children

The efficacy and safety of the use of Lordestin syrup 0.5 mg / ml in children under the age of 1 year has not been established.
In most cases, rhinitis in children under 2 years of age has an infectious nature. No studies have been conducted on the effectiveness of Lordestin syrup 0.5 mg / ml in rhinitis of infectious etiology.
The differential diagnosis between allergic rhinitis and rhinitis of other origin in children under 2 years of age presents certain difficulties. When conducting a differential diagnosis, one should pay attention to the presence or absence of foci of infection or structural anomalies of the upper respiratory tract, a thorough history taking, as well as physical examination, laboratory tests and skin tests.

Severe renal failure

In patients with severe renal insufficiency or those on hemodialysis, the concentration of desloratadine in the blood plasma increases 1.7 and 2.5 times, respectively. A minimal change in the concentration of 3-hydroxydizlorogadine was detected. Desloratadine and 3-hydroxydisloratadine poorly excreted by dialysis. Impaired renal function does not affect the binding of desloratadine and 3-hydroxydeloratadine to plasma proteins. Based on the pharmacokinetics of Lordestin syrup 0.5 mg / ml, caution should be exercised when using the drug in patients with renal insufficiency.

Influence on ability to drive motor transport and work with mechanisms

At the recommended doses, Lordestin 0.5 mg / ml syrup does not affect the ability to drive vehicles or work with machinery.

Terms of sell

You can buy Lordestin syrup without a prescription.