Singlon tabs 10mg #28

Singlon instruction for use

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Description of the drug

Singlon is an antileukotriene drug, an antagonist of cysteinyl leukotrienes of the 1st subtype, used in the treatment of bronchial asthma, as well as in the common cold of allergic etiology. A feature of the drug is its bronchodilator and anti-inflammatory effects. It is prescribed separately for mild forms of AD, in advanced cases, the drug can be combined with basic medicines of therapeutic therapy.

Release form, composition and packaging

The medicinal composition of Singlon chewable tablets includes the active component - montelukast sodium. Auxiliary connections:
    natural cellulose;
    mannitol;
    stearic acid;
    thickener E468;
    sweetener E951;
    hyprolosis;
    iron oxide E172;
    cherry flavor.
The film-coated tablets, along with the main substance, contain: lactose, microcrystalline cellulose, magnesium stearate, croscarmellose sodium, as well as macrogol, titanium dioxide, yellow iron oxide, hyprolose. Each Singlon package contains 7 tablets, in a cardboard box from 2 to 8 contour cells.

pharmachologic effect

Montelukast as part of Singlon is an active blocker of leukotrienes derived from arachidonic acid and mediating inflammatory processes. Thanks to its action, hyperactivity of the bronchi decreases and the frequency of coughing, asthma attacks and other symptoms of asthma decreases. Additionally, the drug prevents excessive secretion in the lumen of the organ and eliminates swelling of the mucous tissues. Description of pharmacokinetic processes:
    the plasma concentration of montelukast reaches a maximum three hours after administration;
    the compound is distributed by blood proteins by 99%, partially penetrates through the placental defense;
    the active substance is metabolized by isoenzymes of cytochrome P450: 3A4, 2C8, 2C9;
    excretion occurs through bile.
Studies have shown that partially metabolites of the drug Singlon are excreted through the intestines and in a minimal amount with urine.

Indications

The drug is prescribed for adult patients, but it is recommended for children 2-5 years old, especially Singlon is in demand for allergic rhinitis and AD. The main use of tablets is associated with the following pathological processes:
    non-infectious inflammation of the respiratory tract and tissues of the bronchial tree with intolerance to aspirin and similar non-steroidal anti-inflammatory drugs;
    prevention of respiratory dysfunction, asthma attacks, night cough, wheezing and other symptoms of the disease;
    prevention and treatment of childhood diseases of the bronchi;
    reduction of exacerbations of AD with viral lesions;
    prevention of spasms of the body during physical overload, inhalation of cold air;
    prevention of allergic rhinitis attacks in young children up to five years.

Contraindications

Reception of Singlon in some conditions is limited, it:
    phenylpyruvic oligophrenia - congenital fermentopathy with impaired phenylalanine metabolism (for chewable tablets);
    hypolactasia - non-perception of lactose due to lactase deficiency and malabsorption syndrome (for film-coated tablets);
    any predisposition to allergies is also a limitation when prescribing a pharmacological agent.
Singlon tablets weighing 0.004 g are contraindicated for a child under two years of age; 0.005 g chewable tablets should not be used until six years of age. Adolescents under the age of 15 are not recommended to use coated tablets.

Dosage

For patients over 15 years of age, Singlon is recommended to be taken orally, one tablet per day, in the evening. The same intake regimen applies to children from 6 to 14 years old, however, if the use of the drug in adults is not tied to meals, then it is better for children to use the drug before or after meals (1-2 hours). The correct dosage and treatment regimen established by the doctor provides a positive effect already during the first day of admission. As for patients suffering from pathologies of the liver and kidneys of moderate severity, dose adjustment for them is not required.

Side effects

When using Singlon, negative effects are noted that can worsen the condition of a patient with asthma and a tendency to allergic nasal congestion:
    asthenic syndrome, expressed by edema, rapid fatigability, dryness of the oral membranes, autoimmune granulomatous inflammation involving the respiratory apparatus;
    anaphylactic reactions; severe cramping, hypoxia attacks, pain;
    heart rhythm disturbance;
    bleeding and subcutaneous hematomas;
    joint and muscle pain;
    abdominal tenderness, nausea, diarrhea, and vomiting;
    numbness of limbs and parts of the body and head;
    lethargy and drowsiness;
    insufficient outflow of bile, eosinophilic pneumonia, hyperechoogenicity of the hepatic parenchyma, sarcoidosis, increased activity of liver enzymes;
    sleep disorder, nightmares;
    trembling hands and feet;
    depressive episodes, aggression, depressed mood of thoughts of suicide;
    headache and fainting conditions;
    nettle fever, facial Quincke's edema, hemorrhage in the form of rashes, erythema with elements of inflammation against the background of allergies.
These pathologies occur when contraindications are not observed, as well as with an independent increase in the recommended dosages of Singlon.

Overdose

Signs of an overdose are known when taking Singlon tablets in an amount of 1 gram, but there were no serious deviations in the patients' health. Symptoms were characterized by the following manifestations:
    weakness and lethargy;
    pain in different parts of the abdomen;
    unbalanced, excited state of the nervous system with a lack of attention;
    headache;
    dilated pupil;
    the urge to vomit with her subsequent departure.
At the same time, even with prolonged use of montelukast - more than six months of 0.2 g, such symptoms were not observed. Judging by the reviews, the side effects of Singlon are indeed present, and with allergic attacks, severe headache, diarrhea and intestinal colic develop. With regard to the nervous system, the clinical picture can worsen on an increasing basis - at first there is weakness and drowsiness, then irritability or apathy appears. Many complain that they have carefully studied the instructions for use of Singlon, which gives a warning about suicidal behavior and depression.

Pregnancy

Despite the fact that medical studies on the effects of Singlon on the body of a pregnant mother have not been conducted, there are known cases of congenital malformations of the extremities in newborn babies whose mothers used the medicine during gestation. In this regard, the reception at all trimesters is not recommended, with the exception of individual cases. There is no specific information about the penetration of montelukast into breast milk, therefore, when prescribing treatment, the doctor must compare all the existing risks.

Application for children

Based on the instructions for use, chewing gums Singlon for administration by children under 6 years of age are not prescribed.

special instructions

Due to the presence of aspartame (E951 supplement) containing phenylalanine, use of Singlon is contraindicated in children diagnosed with phenylketonuria. The medicine is not used to relieve severe asthma attacks - inhalations with beta-adrenostimulants should be prescribed for this. With a side effect of eosinophilia in the treatment of bronchial asthma, oral glucocorticosteroids will help eliminate unwanted symptoms. The patient should be warned about the threat of the development of other pathological conditions - neuropathy, exacerbation of heart and vascular diseases. Driving vehicles and other dangerous types of work are excluded while taking the drug. The average price for Singlon chewable tablets (0.005 g) in pharmacies ranges from 700 to 900 rubles.

Drug interaction

Singlon is perfectly combined with classic medicines intended for long-term AD therapy. If the tablets are used in the prescribed dosage, their interaction with histamines, bronchodilators and anti-asthma drugs is neutral. Montelukast also does not affect the effectiveness of tablet, synthetic contraceptives such as Norethisterone and Ethinyl estradiol. The drug enhances the effect of inhaled glucocorticosteroids - with a positive effect, the dosage of GCS is reduced gradually, while it is undesirable to dramatically replace them with Single.

Terms and conditions of storage

With the above pathologies, you should contact a therapist, allergist or pulmonologist, if the problem has affected the child - to the pediatrician. The specialist must write out Singlon, since it is impossible to buy it at a pharmacy without a prescription. Shelf life of the drug is estimated at two years, and after this period it can not be used. When storing the product should ensure dryness in the room, the absence of light and a temperature of not more than 25 degrees.

Terms of sell

You don't need a prescription to buy Singlon.