Instruction for Pulmicort
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Release form and composition
The drug is available in pharmacies in 2 versions: turbuhaler and suspension. The second is most convenient for evaporation in a nebulizer, which will make therapeutic inhalations the most effective. The concentrated active substance in the solution has 250 mcg / ml. either 500 mcg / ml. The powder can be bought in two dosage forms: 200 d. 0.1 mg each. or 100 d. 0.2 mg. The packaging is a cardboard box.
Pulmicort belongs to the class of artificially isolated glucocorticosteroids, where budesonide is the basic element. Additionally, sodium citrate, citric acid, polysorb-80, sodium salt are included.
Pharmacokinetics
The absorption of budesonide in the human body acts in a short time. About 1/4 of the total medication enters the lungs. In the blood, the highest concentration of the active substance is observed after half an hour. Metabolism occurs when interacting with CYP-3A4 enzymes, at the end of it the processed components are excreted from the body with urine. In the presence of liver diseases, this process may take a longer period of time. The initial effect is observed within a few hours, and the result from systematic procedures becomes noticeable in two weeks.
Indications for use
Pulmicort inhalation is prescribed for all types of asthma (bronchial and others), nasopharyngitis, hay fever, chronic rhinitis, pulmonary obstruction, infectious bronchial infection, cough of unclear etiology, psoriasis, dermatitis, and polyp growth.
The determination of the frequency of use and dosage of Pulmicort for inhalation is carried out exclusively by a specialist according to the individual characteristics of the patient.
For children
Suspension for evaporation in a nebulizer for children is prescribed for laryngitis, bronchitis and dry cough with a whistle. It improves airway patency, quickly eliminating swelling of the mucosa. Usually Pulmicort inhalation with saline is an emergency measure when the patient worsens, and the frequency and dose are prescribed based on the age and general course of the disease.
According to the popular doctor Dr. Komarovsky today: “the drug is completely safe and harmless to young children and infants, because instantly absorbed through the lungs, has a directed action and is excreted through the kidneys in a short time ”. Properly performed inhalation quickly helps even with complications of asthma or bronchitis.
For adults
The medication is indicated to relieve manifestations of the acute form of laryngotracheitis, complicated by a strong cough or hoarse voice. In this case, inhalation is carried out 3 days twice a day. The duration of treatment is extended according to the doctor’s instructions, based on the patient’s individual indicators.
To improve the medicinal effect of the drug, it is alternated with saline. This use contributes to the rapid removal of sputum.
With attacks of shortness of breath in emergency situations, alternate inhalations of Berodual and Pulmicort help. They must be done every 20 minutes. Berodual acts as an antispasmodic, complementing the effect.
Contraindications
Taking the drug is strictly prohibited for children from 0 to 6 months. It is contraindicated in adults with hypersensitivity to budesonide, in the presence of cirrhosis of the liver, pulmonary tuberculosis or skin, pulmonary infections, dermatitis lesions of various nature, tumors of the skin of the face or head. Budesonide-containing agent is prescribed with caution to people suffering from various chronic kidney diseases.
Dosage and administration for inhalation
Pulmicort is prescribed for a course of 1 to several weeks, depending on the course of the disease. A noticeable effect appears after a couple of hours. The positive effect of the drug becomes noticeable after one use, however, its one-time use does not make sense. A certain range of respiratory diseases is treated for more than 30 days. How exactly the course will last can be diagnosed after 5 days of systematic exposure.
For children
Pulmicort dose for inhalation is prescribed only by a pulmonologist after preliminary studies and collection of tests. In most cases, children from six months of the maximum allowable daily dosage of 0.5 mg. With regularly recurring long-term attacks, it can be increased to 1 mg. (4 ml.). In the first situation, the procedures are usually performed once a day, in the second - twice, in the morning and before bedtime.
The instructions for use of Pulmicort for inhalation indicate that before use it must be "diluted with 0.9% saline to 2 ml." The volumes of both solutions are mixed approximately the same and equal proportions.
For adults
At the beginning of treatment, inhalations with 1 mg are usually prescribed. medication. For dilution, saline, acetylcysteine, terbutaline or fenoterol are used, they are mixed with Pulmicort in equal proportions. The daily norm of a person over 18 years old contains from 0.5 to 4 mg of budesonide. In case of relapse, the dose is increased to the maximum allowable volume, and inhaled vapors of undiluted suspension are inhaled.
How to breed Pulmicort for inhalation?
1 ml the drug is diluted with a similar amount of saline to a total volume of 2 ml. After the procedure, it is necessary to thoroughly rinse the oral cavity to prevent the appearance of candidiasis.
How to carry out the procedure
To carry out the procedure with Pulmicort suspension for inhalation, you need to responsibly approach the choice of the device itself. The ultrasonic option is not suitable for this purpose due to the large loss of useful properties during spraying.
Before use, the drug must be diluted with a solution of sodium chloride in equal proportions.
Shake the mini container, open and hold in a vertical position.
Carefully insert the nebula directly into the inhaler and pour the contents into the desired compartment.
At the end of the session, you need to wash your face, and rinse your mouth with boiled water with soda. Pulmicort's open packaging for a nebulizer can only be stored for 12 hours at a temperature of no higher than 30 C. After this time, the drug cannot be used.
It is recommended to clean the tube and mask after each use, thoroughly rinsing with boiling water or wiping with a dry cotton cloth.
Side effects
Undesirable results appear in 1 out of 10 cases of using the medication. This is due to its hormonal basis, prolonged exposure of which can worsen the state of immunity, or the body's response to budesonide.
Possible side effects include the appearance of a fungus in the mouth, dryness, hoarseness, nausea, irritability, sleep disturbances, depression, irritation or allergic skin rashes, etc. To prevent them after the child breathes the drug, he should rinse his mouth and wash with soap. Parts of the inhaler should be regularly cleaned after each procedure.
If you use the drug for a long time, the growth of the child may be delayed. This is a temporary and reversible process that will come to naught after the cessation of inhalation. The growth and development parameters of the child must be kept under special control and the doctor should be informed about the delay. Pulmicort is prescribed for treatment for children and adolescents only after analyzing the potential consequences of taking and the ratio of the negative sides with the therapeutic effect and the intended benefits for the child's body.
With frequent use or too large doses, the manifestation of hypofunctioning of the adrenal glands is possible. In this case, it is recommended to reduce the intake and lower the dosage after consulting a pulmonologist.
Pregnancy and lactation
Pathogenic reactions in pregnant women have not been studied. When conducting experiments involving animals, no pathogenic effect was found, but there is no evidence that the drug does not affect the fetus. Pregnant and lactating women should minimize the dosage and frequency of taking the medication. During lactation, it was noted that the active substance passes into breast milk, but its negative effect on the baby is not fixed.
Special instructions and recommendations for use Pulmicort
When prescribing budesonide, it is taken into account that it can not be taken with itraconazole or ketonazole. If they are mandatory for treatment, then the time interval between them is large.
If the patient is transferred from oral glucocorticosteroids, pain in the muscles or joints may appear. In this case, the dosage is usually increased.
Increased attention should be paid to patients who have long consumed elevated doses of hormonal preparations of a similar group. They may exhibit hypofunctioning of the adrenal glands, especially in situations directly related to stress. Patients who have undergone surgical operations need especially close monitoring, they may need to enter additional therapy using glucocorticosteroid systemic drugs.
Constant monitoring of the production of hormones by the adrenal glands is carried out when transferring from systemic hormonal drugs to inhaled ones. The course of systemic glucocorticosteroids is not interrupted, but their dose is gradually reduced.
The onset of symptoms of vomiting, nausea, or fatigue is most often due to hormonal deficiency.
If allergies occur, use antihistamines.
Inhalation should be done between meals. Often after exposure to the drug, hunger intensifies or nausea appears, so the procedures are not recommended to be performed immediately after eating, or immediately in front of it.
The effect of Pulmicort on the patient's body is increased when taking estrogen-containing drugs or methandrostenolone, because they contribute to an increase in the concentration of budesonide in the blood. Strengthening of medicinal properties occurs with the preliminary inhalation of vapors of the beta-adrenomimetic drug group, which expand the airways and improve their patency.
Terms and conditions of storage
Pulmicort has a shelf life of 2 years from the date of issue. Keep out of reach of children at temperatures below 30 degrees Celsius. After opening, the packaging must be kept in the refrigerator for no longer than 3 months. Open nebulas are stored for no more than 12 hours.
Terms of sell
You don't need a prescription to buy Pulmicort.