Papaverine supp 20mg #10

Instruction for Papaverine

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Release form and composition

Suppositories (suppositories) Papaverine are small, torpedo-shaped, white in color and smooth. The main active ingredient of the drug is papaverine, its content in one suppository is 20 mg. suppositories Papaverine are packaged in a blister pack of 10 pieces. The carton pack contains 1 blister packaging and instructions for use of the drug.

pharmachologic effect

Active ingredient suppositories Papaverine inhibits (inhibits) the enzyme phosphodiesterase (PDE) in the smooth muscle cells of the walls of hollow organs. This leads to a decrease in intracellular concentration of cyclic adenazine monophosphate (cAMP) and calcium ions, which causes relaxation of muscle fibers and a decrease in spasm. The drug acts on the smooth muscles of the hollow organs of the digestive, hepatobiliary system, the hollow structures of the urogenital tract, as well as the arterial vessels. suppositories Papaverine lead to a decrease in spasm of the walls of organs and the expansion of the lumen of their cavity. Relaxation of the smooth muscles of the arterial vessels causes a decrease in the level of systemic arterial pressure. With a high concentration of papaverine in the blood, it can lead to a decrease in the conductivity of the nerve impulse in the cardiac conduction system, as well as a decrease in the excitability of the myocardium (cardiac muscle).
After the injection of papaverine into the rectal cavity, the active ingredient is rapidly and almost completely absorbed into the systemic circulation. It is evenly distributed in the tissues of the body, penetrates through the blood-brain barrier into the structures of the central nervous system. During pregnancy, papaverine can enter the body of a developing fetus through the placental barrier. It also passes into breast milk during lactation. The active substance of papaverine suppositories is metabolized in the liver to form inactive degradation products, which are excreted by the kidneys. The half-life (the time during which half of the entire dose of the drug is excreted from the body) ranges from 30 minutes to 2 hours.

Indications for use

The use of suppositories Papaverine is indicated for the pathogenetic and symptomatic reduction of the spasm of the smooth muscles of the hollow organs of the digestive, hepatobiliary, urinary systems, peripheral vessels (including vessels of the brain and kidneys), and bronchi. Also, the drug is used to reduce the severity of angina (pressing pain in the heart, which is a consequence of constriction of the cardiac coronary vessels). In surgical practice, papaverine suppositories can be used for premedication (medical preparation of the body for anesthesia).

Contraindications

Using suppositories Papaverine contraindicated in several pathological and physiological conditions of the body, which include:
    Hypersensitivity to the active substance or auxiliary components of the drug.
    Glaucoma is a pathological increase in the level of intraocular pressure.
    Severe liver failure.
    Atrioventricular block - a violation of the nerve impulse through the atrioventricular node.
    Old age of the patient, which is associated with a significant risk of fever (hyperthermia).
    Children age up to 6 months.
Before you start using papaverine suppositories, make sure that there are no contraindications.

Dosage and administration

Suppositories Papaverine designed for rectal use, they are carefully injected into the lumen of the rectum. The average therapeutic dose is 20-40 mg (1-2 suppositories) 2-3 times a day, while the interval between the introduction should not be less than 4 hours. Dosage for children aged 1 to 12 years is calculated based on the concentration of the drug 200-300 mg per 1 kg of body weight of the child. For the elderly, a single dose should not exceed 10 mg.

Side effects

Against the background of the use of suppositories, papaverine may develop nausea, constipation, drowsiness, lower blood pressure (hypotension), excessive sweating, and an increase in the activity of hepatic transaminase enzymes (ALT, AST) in the blood, which indicates damage to the hepatocytes (liver cells). With the development of adverse reactions, the doctor decides whether to discontinue the drug, depending on their severity and nature.

special instructions

Before using suppositories Papaverine should carefully read the instructions for the drug. There are several special indications that are worth paying attention to, these include:
    The drug is used with caution in the presence of concomitant chronic renal failure with a moderately pronounced violation of the functional activity of the kidneys, hypothyroidism (decreased functional activity of the thyroid gland), insufficiency of the functional activity of the adrenal glands, hyperplasia (benign increase in volume) of the prostate gland in men, supraventricular tachycardia (increase in contractions) ), shock states of the body, accompanied by the development of multiple organ failure.
    While using suppositories, papaverine excludes alcohol.
    The use of the drug for pregnant and lactating women is not recommended, as there is no reliable data on the safety of the drug for the developing fetus and infant.
    The active ingredient of suppositories Papaverine can interact with drugs from other pharmacological groups, so you should consult with your doctor about their possible use.
    There is no reliable data on the effect of the drug on the functional activity of the cerebral cortex, due to the possible development of a side effect in the form of drowsiness, it is not recommended to do work associated with the need for increased concentration and psychomotor speed.
In the pharmacy network suppositories papaverine prescription. It is not recommended to use them independently without an appropriate doctor's prescription.

Overdose

With a significant excess of the recommended therapeutic dose of suppositories, papaverine develops nausea, vomiting, a decrease in the level of systemic blood pressure, as well as a violation of the frequency and rhythm of heart contractions (arrhythmia). Treatment of significant overdose is symptomatic therapy, as well as hemodialysis (hardware cleansing of the blood).

Terms and conditions of storage

The shelf life of papaverine suppositories is 2 years from the date of their manufacture. The drug should be stored in the original original packaging, dark, dry, out of the reach of children at an air temperature not higher than + 25 ° C.

Terms of sell

You don't need a prescription to buy Papaverine.