Nalgesin Forte tabs 550mg #20


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Nalgesin Forte instruction

You can buy Nalgesin Forte here

The drug is manufactured by the manufacturer in a single pharmacological form - tablets, on top of a film-coated film. The shape of the tablets is convex on both sides, oval, on one side there is a risk, the color of the tablets is blue. Packed in blisters of 10 pieces. Each pack of cardboard holds 1-2 blisters.
The main active ingredient in the composition of the tablets "Nalgesin Forte" is sodium naproxen (550 mg). As additional components are used: indigo carmine, hypromellose, titanium dioxide, macrogol, microcrystalline cellulose, talc, magnesium stearate, purified water, povidone K30.

Pharmacological properties of "Nalgesin forte"

The active substance in the composition of the drug - naproxen, which is able to provide antipyretic, anti-inflammatory, analgesic effects. The mechanism of drug action is based on the ability of the active component to non-selectively inhibit the activity of cyclooxygenases of the first and second groups. As a result of this action, there is a violation of the synthesis of prostaglandins, as a result of which the process of inflammation is inhibited, the pain decreases.
As indicated by the instructions for use, the tablets "Nalgesin forte" dissolve well, rather quickly absorbed from the gastrointestinal tract, provide a rapid onset of the effect of anesthesia.
The active substance in the composition of the drug is absorbed from the digestive tract quickly and completely. The drug is characterized by a high degree of bioavailability, which is about 95%. It should be noted that the food does not affect the speed and completeness of absorption. The maximum concentration of naproxen in the patient's blood is noted 2 hours after application. Naproxen binds to plasma proteins by at least 99%.
Naproxen metabolism occurs in the liver tissue under the influence of the enzyme CYP2C9, resulting in the formation of dimethyl naproxen.
The clearance of the active substance is 0.13 ml / min / kg. Subliminalization takes up to 15 hours. Excretion is carried out mainly by the kidneys, moreover, about 10% of naproxen is excreted in an unchanged condition, the rest in the form of inactive metabolites. In patients suffering from renal impairment, accumulation of metabolites of the active substance is sometimes noted.
To achieve the equilibrium concentration of the drug in the blood can be after taking 4-5 doses, that is, 2-3 days of therapy.

Indications for use

The drug "Nalgesin forte" is indicated for use in the following cases:
    Pathology of upper respiratory tract with inflammatory or infectious etiology, characterized by pronounced painful manifestations (for example, tonsillitis, pharyngitis, otitis media).
    Feverish syndrome accompanying colds, infectious diseases.
    Pathologies in the musculoskeletal system: rheumatoid, gouty psoriatic arthritis, chronic juvenile arthritis, rheumatic soft tissue lesions, osteoarthritis of the spine, peripheral joints, tendovaginitis, ankylosing spondyloarthritis, bursitis.
    Pain syndromes of moderate, mild severity: toothache, headache, algodicmenorrhea, migraine, adnexitis, myalgia, neuralgia, ossalgia, lumboischialgia, post-traumatic pain syndrome (occurring on the background of sprains, dislocations), pain after operations (maximally traumatic syndrome (arising against sprains, dislocations), pain after operations (maximally traumatic) orthopedics, gynecology). Indications for use "Nalgesin forte" are described in detail in the instructions.
It is worth noting that the drug is a symptomatic drug, that is, by using it, you can reduce elevated body temperature, reduce the process of inflammation, stop pain. He cannot influence the course of the disease.

Contraindications to use

"Nalgesin forte" is absolutely contraindicated for use if the patient has the following physiological or pathological conditions:
    Hypersensitivity to any component that is in the composition of the drug.
    A history of attacks on bronchial obstruction, urticaria, rhinitis, triggered by the use of acetylsalicylic acid or other antioxidants.
    Complete and incomplete intolerance to acetylsalicylic acid - bronchial asthma, rhinosinusitis, nasal mucous polyps, urticaria.
    Ulcerative and erosive damage to the mucous membranes of the duodenum, stomach.
    Exacerbations of intestinal inflammatory diseases (for example, ulcerative colitis of non-specific type).
    Active bleeding in the digestive tract.
    Cerebrovascular and other types of bleeding, impaired hemostasis.
    The recovery period after coronary artery bypass surgery.
    The expressed forms of a liver failure.
    Active pathology of the kidneys.
    Severe forms of renal failure, confirmed hyperkalemia.
    Progressive forms of renal pathologies.
    Depressed bone marrow hematopoiesis.
    Lactation period, pregnancy.
The preparation contains a high dosage of the active ingredient, and therefore, it is not recommended for use in patients under 15 years of age.
In accordance with the instruction "Nalgesin forte" is relatively contraindicated in the following cases:
    Elderly age.
    Increased susceptibility to other analgesic drugs.
    Concurrent use of anticoagulants ("Warfarin"), antiplatelet agents ("Clopidogrel", acetylsalicylic acid), oral glucocorticosteroids (including prednisolone drugs) that inhibit serotonin reuptake (Citalopram, Sertralin, Fluoxetine "" .
    Prolonged use of drugs NSAIDs.
    Frequent use of alcoholic beverages.
    Hyperlipidemia, dyslipidemia.
    Bronchial asthma.
    Impaired blood clotting.
    Congestive heart failure.
    Pathology of the peripheral artery system.
    Cerebrovascular pathology.
    Helicobacter pylori infection.
    Presence in the history of information about the occurrence of ulcerative lesions of the digestive tract.
    Severe forms of somatic pathologies.

Using Nalgesin Forte

The drug is intended for oral administration, the meals on the efficacy of the drug have no effect.
It is recommended to use the drug in the minimum effective dosage, while the course of therapy should be as short as possible. This approach reduces the likelihood of negative manifestations on the part of the gastrointestinal tract.
Stop therapy, arbitrarily change the dosage prescribed by the doctor is strictly prohibited.
In order to relieve pain of moderate severity, as a rule, it is enough to take the drug once a day for 1-2 tablets. With severe pain and the condition that there is no history of pathology of the gastrointestinal tract in the history, the dosage may be increased to 3 tablets. However, therapy in this case should not last more than a crescent.
In order to reduce the increased body temperature, it is indicated to take one pill, after which the techniques are repeated every 6-8 hours, while halving the dose.
In order to prevent the development of migraine, it is recommended to take one tablet twice a day. If the duration of the attacks, their frequency, intensity does not decrease during the month, it is necessary to abandon the use of the drug. When the first signs of a migraine attack occur, it is recommended to take 1.5 tablets. If necessary, it is allowed to take 0.5-1 tablets after half an hour.
For gynecological pains (with adnexitis, algomenorrhea, after insertion of the intrauterine device), it is recommended to take 1 tablet once, repeat the administration after 8 hours, reducing the dose by half.
With gout attacks, the initial dosage of Nalgesin Forte is 1.5 tablets. After 8 hours, it is recommended to take 1 tablet, and then 0.5 tablets every 8 hours.
To eliminate rheumatoid pains, it is indicated to take 1-2 tablets twice daily. Morning and evening doses may vary depending on the prevailing symptom (night pain, morning stiffness).
In the case when the effect of the use of the product seems insufficient or, on the contrary, excessively strong, it is important to inform the specialist about this.

Negative effects

According to the instructions for use and reviews to "Nalgesin forte", the following negative manifestations may occur during use:
    Impaired liver function, jaundice, increased transaminase activity of the liver, bloody vomiting, melena, ulcers, erosive lesions of the gastrointestinal tract organs, bleeding in the gastrointestinal tract, nausea, constipation, diarrhea, abdominal pain, dyspeptic manifestations, ulcerative stomatitis from the side of the gastrointestinal tract.
    Renal failure, renal papillary necrosis, glomerulonephritis, hematuria, interstitial nephritis, irregularities in the menstrual cycle, nephrotic syndrome - on the part of the reproductive system and urine excretion system.
    Aseptic meningitis, depression, muscle weakness, dizziness, malaise, headache, myalgia, cognitive dysfunction, slow reaction rate, sleep disturbance, insomnia, drowsiness, inability to concentrate, hearing loss - on the part of the central nervous system.
    Pneumonitis eosinophilic nature of the respiratory system.
    Palpitations, congestive heart failure, vasculitis, puffiness, shortness of breath - from the side of the heart system and blood vessels.
    Eosinophilia, granulocytopenia, thrombocytopenia, hemolytic anemia, aplastic anemia, leukopenia - on the part of the blood-forming organs.
    Impaired hearing, vision, tinnitus - by the senses.
    Purpura, alopecia, ecchymosis, photodermatosis, excessive sweating, itching - from the dermis.
    Epidermal necrosis, Stevens-Johnson syndrome, angioedema, erythema multiforme, rash on the dermis, urticaria - as allergic manifestations.
    Thirst, hyperthermia, hypoglycemia, hyperglycemia - as other reactions.
It is important to note that negative effects have a character depending on the dose taken.
What else does the instruction manual tell us about “Nalgesin forte”?


Intoxication with the drug is manifested by the appearance of the following symptoms: renal failure, impaired consciousness, bloody vomiting, tinnitus, melena, irritability, drowsiness, weakness, dyspepsia (for example, vomiting, nausea, abdominal pain, heartburn), convulsions.
In case of drug overdose, the patient is shown to provide gastric lavage, intake of enterosorbing agents, antacids. In addition, symptomatic therapy is indicated. Due to the high degree of binding of the active substance with plasma proteins, hemodialysis is ineffective.
This confirms the instructions to the tablets "Nalgesin forte".

Interaction with other drugs

Naproxen has the ability to increase the bleeding time, it is important to take into account patients taking anticoagulants.
With the parallel use of naproxen and antacids based on aluminum and magnesium, a decrease in the absorption of the first is observed. When combined with probenecid, the concentration of naproxen in the blood, on the contrary, increases.
The simultaneous use of hydantoins and anticoagulants with “Nalgesin forte” leads to the potentiation of their effects and, as a result, to the onset of symptoms of intoxication.
The active ingredient of the drug is able to slow excretion, increase the likelihood of toxic effects of methotrexate, phenytoin, sulfonamides.
Concurrent use with cyclosporine and angiotensin-converting enzyme inhibitors increases the risk of liver failure.
Before starting the patient should inform the doctor about all the medications that he takes, as well as the presence of an allergy to any substance.
The instructions for use analogs "Nalgesin forte" is not listed.

Comparison with "Pentalgin"

These drugs are analogues of each other. It is rather difficult to judge the advantages and disadvantages of this or that drug, as patients report high efficacy of both drugs.
It should be borne in mind that for each individual person the most effective will be the one that is right for him. It will depend not only on the characteristics of the patient, but also on the nature of the disease.
It can only be noted that "Nalgesin Forte" is much cheaper than "Pentalgin", and for some patients this fact is decisive.
Be that as it may, when choosing a drug, you should listen to the doctor who will select the most suitable option for a particular situation and person.
Of course, it is important to follow the instructions for use.


Patients who have experience with the indicated drug therapy report that it is highly effective and allows to relieve even severe pain in cases where other drugs are ineffective. It is also reported that the effect of the use of a medical drug persists for a long time. However, experts note that the effectiveness and long therapeutic effect of the drug give not any additional components in its composition, but the fact that it contains twice the active component.
Among the shortcomings in the reviews about "Nalgesin Forte", patients note that the drug has a very extensive list of contraindications that prevent its use, and possible adverse events. It is often reported that it causes a variety of dyspeptic manifestations and allergic reactions.
In addition, the drug is relatively expensive, and the tablet has a rather large size, which makes it difficult to swallow.
It is important to remember that the appointment of the drug should be carried out by a doctor who will take into account all the nuances of the disease and the upcoming therapy.

Terms of sell

You don't need a prescription to buy Nalgesin Forte.